LY354740 is a potent and highly selective group II metabotropic glutamate receptor agonist in cells expressing human glutamate receptors

The novel compound LY354740 is a conformationally constrained analog of glutamate, which was designed for interaction at metabotropic glutamate (mGlu) receptors. In this paper the selectivity of LY354740 for recombinant human mGlu receptor subtypes expressed in non-neuronal (RGT) cells is described....

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Veröffentlicht in:	Neuropharmacology 1997, Vol.36 (1), p.1-11
Hauptverfasser:	SCHOEPP, D. D, JOHNSON, B. G, MONN, J. A, WRIGHT, R. A, SALHOFF, C. R, MAYNE, N. G, WU, S, COCKERHAM, S. L, BURNETT, J. P, BELEGAJE, R, BLEAKMAN, D
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological and medical sciences Bridged Bicyclo Compounds - pharmacology Cell Line - metabolism Colforsin - pharmacology Cyclic AMP - metabolism Excitatory Amino Acid Agonists - pharmacology Glutamatergic system (aspartate and other excitatory aminoacids) Humans Medical sciences Neuropharmacology Neurotransmitters. Neurotransmission. Receptors Patch-Clamp Techniques Pharmacology. Drug treatments Phosphatidylinositols - metabolism Receptors, Metabotropic Glutamate - agonists
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