Increased levels of serum fibroblast growth factor-2 in diabetic pregnant women with retinopathy
Fibroblast growth factor-2 (FGF-2) is a potent mitogen and angiogenic factor normally absent from the adult circulation. We have previously shown that it appears in normal maternal serum and that circulating FGF-2 levels are elevated in pregnancies complicated by diabetes. This study was performed t...
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| Veröffentlicht in: | The journal of clinical endocrinology and metabolism 1997-05, Vol.82 (5), p.1452-1457 |
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| container_title | The journal of clinical endocrinology and metabolism |
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| creator | HILL, D. J FLYVBJERG, A ARANY, E LAUSZUS, F. F KLEBE, J. G |
| description | Fibroblast growth factor-2 (FGF-2) is a potent mitogen and angiogenic factor normally absent from the adult circulation. We have previously shown that it appears in normal maternal serum and that circulating FGF-2 levels are elevated in pregnancies complicated by diabetes. This study was performed to determine whether serum FGF-2 is more abundant in pregnant diabetic women with retinopathy than in those without. Serum was collected monthly between 14-30 weeks gestation and every 2 weeks from then until delivery (35-38 weeks) from 36 women with type 1 diabetes. FGF-2 was extracted by heparin-Sepharose affinity chromatography and quantified by specific RIA. Patients were divided according to the White classification of diabetes. In 17 women without retinopathy (White groups B, C, and D0), immunoreactive FGF-2 was detectable at 14 weeks (mean +/- SEM, 154 +/- 39 pmol/L), was maximal after 26 weeks (306 +/- 38 pmol/L), after which values steadily declined to term (212 +/- 48 pmol/L). In 19 women with simplex or proliferative retinopathy (White groups D+ and R), circulating levels of FGF-2 were significantly greater between 22-32 weeks gestation (22 weeks, 480 +/- 102 vs. 239 +/- 38 pmol/L; P < 0.05). Serum FGF-2 was significantly correlated with hemoglobin A1c levels at 22, 30, and 34 weeks gestation. The mean birth weight of the infants did not significantly differ between groups. Macroalbuminuria was absent in all patients, and creatinine clearance and blood pressure did not significantly differ between the two groups. The results suggest that serum FGF-2 is substantially elevated in pregnant diabetic women with retinopathy in second and early third trimesters. It is unlikely that in these patients this was primarily due to altered FGF-2 clearance, but may relate to excessive production by the utero-placental compartment. The high circulating levels of FGF-2 may be causally related to the development of diabetic retinopathy. |
| doi_str_mv | 10.1210/jc.82.5.1452 |
| format | Article |
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J ; FLYVBJERG, A ; ARANY, E ; LAUSZUS, F. F ; KLEBE, J. G</creator><creatorcontrib>HILL, D. J ; FLYVBJERG, A ; ARANY, E ; LAUSZUS, F. F ; KLEBE, J. G</creatorcontrib><description>Fibroblast growth factor-2 (FGF-2) is a potent mitogen and angiogenic factor normally absent from the adult circulation. We have previously shown that it appears in normal maternal serum and that circulating FGF-2 levels are elevated in pregnancies complicated by diabetes. This study was performed to determine whether serum FGF-2 is more abundant in pregnant diabetic women with retinopathy than in those without. Serum was collected monthly between 14-30 weeks gestation and every 2 weeks from then until delivery (35-38 weeks) from 36 women with type 1 diabetes. FGF-2 was extracted by heparin-Sepharose affinity chromatography and quantified by specific RIA. Patients were divided according to the White classification of diabetes. In 17 women without retinopathy (White groups B, C, and D0), immunoreactive FGF-2 was detectable at 14 weeks (mean +/- SEM, 154 +/- 39 pmol/L), was maximal after 26 weeks (306 +/- 38 pmol/L), after which values steadily declined to term (212 +/- 48 pmol/L). In 19 women with simplex or proliferative retinopathy (White groups D+ and R), circulating levels of FGF-2 were significantly greater between 22-32 weeks gestation (22 weeks, 480 +/- 102 vs. 239 +/- 38 pmol/L; P < 0.05). Serum FGF-2 was significantly correlated with hemoglobin A1c levels at 22, 30, and 34 weeks gestation. The mean birth weight of the infants did not significantly differ between groups. Macroalbuminuria was absent in all patients, and creatinine clearance and blood pressure did not significantly differ between the two groups. The results suggest that serum FGF-2 is substantially elevated in pregnant diabetic women with retinopathy in second and early third trimesters. It is unlikely that in these patients this was primarily due to altered FGF-2 clearance, but may relate to excessive production by the utero-placental compartment. The high circulating levels of FGF-2 may be causally related to the development of diabetic retinopathy.</description><identifier>ISSN: 0021-972X</identifier><identifier>EISSN: 1945-7197</identifier><identifier>DOI: 10.1210/jc.82.5.1452</identifier><identifier>PMID: 9141532</identifier><identifier>CODEN: JCEMAZ</identifier><language>eng</language><publisher>Bethesda, MD: Endocrine Society</publisher><subject>Adult ; Biological and medical sciences ; Blood Glucose - metabolism ; Diabetic Retinopathy - blood ; Diseases of mother, fetus and pregnancy ; Female ; Fibroblast Growth Factor 2 - blood ; Glycated Hemoglobin A - metabolism ; Gynecology. Andrology. Obstetrics ; Humans ; Medical sciences ; Pregnancy ; Pregnancy in Diabetics - blood ; Pregnancy. Fetus. Placenta ; Reference Values ; Time Factors</subject><ispartof>The journal of clinical endocrinology and metabolism, 1997-05, Vol.82 (5), p.1452-1457</ispartof><rights>1997 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c315t-dcaa3c65fa501a2f7f96443b323abbbc35a57eb08d549e44be6d577ed53ec87d3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,778,782,27907,27908</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=2661667$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/9141532$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>HILL, D. J</creatorcontrib><creatorcontrib>FLYVBJERG, A</creatorcontrib><creatorcontrib>ARANY, E</creatorcontrib><creatorcontrib>LAUSZUS, F. F</creatorcontrib><creatorcontrib>KLEBE, J. G</creatorcontrib><title>Increased levels of serum fibroblast growth factor-2 in diabetic pregnant women with retinopathy</title><title>The journal of clinical endocrinology and metabolism</title><addtitle>J Clin Endocrinol Metab</addtitle><description>Fibroblast growth factor-2 (FGF-2) is a potent mitogen and angiogenic factor normally absent from the adult circulation. We have previously shown that it appears in normal maternal serum and that circulating FGF-2 levels are elevated in pregnancies complicated by diabetes. This study was performed to determine whether serum FGF-2 is more abundant in pregnant diabetic women with retinopathy than in those without. Serum was collected monthly between 14-30 weeks gestation and every 2 weeks from then until delivery (35-38 weeks) from 36 women with type 1 diabetes. FGF-2 was extracted by heparin-Sepharose affinity chromatography and quantified by specific RIA. Patients were divided according to the White classification of diabetes. In 17 women without retinopathy (White groups B, C, and D0), immunoreactive FGF-2 was detectable at 14 weeks (mean +/- SEM, 154 +/- 39 pmol/L), was maximal after 26 weeks (306 +/- 38 pmol/L), after which values steadily declined to term (212 +/- 48 pmol/L). In 19 women with simplex or proliferative retinopathy (White groups D+ and R), circulating levels of FGF-2 were significantly greater between 22-32 weeks gestation (22 weeks, 480 +/- 102 vs. 239 +/- 38 pmol/L; P < 0.05). Serum FGF-2 was significantly correlated with hemoglobin A1c levels at 22, 30, and 34 weeks gestation. The mean birth weight of the infants did not significantly differ between groups. Macroalbuminuria was absent in all patients, and creatinine clearance and blood pressure did not significantly differ between the two groups. The results suggest that serum FGF-2 is substantially elevated in pregnant diabetic women with retinopathy in second and early third trimesters. It is unlikely that in these patients this was primarily due to altered FGF-2 clearance, but may relate to excessive production by the utero-placental compartment. The high circulating levels of FGF-2 may be causally related to the development of diabetic retinopathy.</description><subject>Adult</subject><subject>Biological and medical sciences</subject><subject>Blood Glucose - metabolism</subject><subject>Diabetic Retinopathy - blood</subject><subject>Diseases of mother, fetus and pregnancy</subject><subject>Female</subject><subject>Fibroblast Growth Factor 2 - blood</subject><subject>Glycated Hemoglobin A - metabolism</subject><subject>Gynecology. Andrology. Obstetrics</subject><subject>Humans</subject><subject>Medical sciences</subject><subject>Pregnancy</subject><subject>Pregnancy in Diabetics - blood</subject><subject>Pregnancy. Fetus. Placenta</subject><subject>Reference Values</subject><subject>Time Factors</subject><issn>0021-972X</issn><issn>1945-7197</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1997</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo9kEtLxDAURoMoOj52boUsxJUd82zapQy-QHCj4C7epDfaoW3GpOPgv7fi4OouzuGDewg55WzOBWdXSz-vxFzPudJih8x4rXRheG12yYwxwYvaiNcDcpjzkjGulJb7ZL_mimspZuTtYfAJIWNDO_zCLtMYaMa07mloXYqugzzS9xQ34wcN4MeYCkHbgTYtOBxbT1cJ3wcYRrqJPQ50005imsgQVzB-fB-TvQBdxpPtPSIvtzfPi_vi8enuYXH9WHjJ9Vg0HkD6UgfQjIMIJtSlUtJJIcE556UGbdCxqtGqRqUclo02Bhst0VemkUfk4m93leLnGvNo-zZ77DoYMK6zNVVdT1-zSbz8E32KOScMdpXaHtK35cz-BrVLbythtf0NOuln292167H5l7cFJ36-5ZA9dCHB4Nv8r4my5GVp5A8CMH-R</recordid><startdate>19970501</startdate><enddate>19970501</enddate><creator>HILL, D. J</creator><creator>FLYVBJERG, A</creator><creator>ARANY, E</creator><creator>LAUSZUS, F. F</creator><creator>KLEBE, J. G</creator><general>Endocrine Society</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19970501</creationdate><title>Increased levels of serum fibroblast growth factor-2 in diabetic pregnant women with retinopathy</title><author>HILL, D. J ; FLYVBJERG, A ; ARANY, E ; LAUSZUS, F. F ; KLEBE, J. G</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c315t-dcaa3c65fa501a2f7f96443b323abbbc35a57eb08d549e44be6d577ed53ec87d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1997</creationdate><topic>Adult</topic><topic>Biological and medical sciences</topic><topic>Blood Glucose - metabolism</topic><topic>Diabetic Retinopathy - blood</topic><topic>Diseases of mother, fetus and pregnancy</topic><topic>Female</topic><topic>Fibroblast Growth Factor 2 - blood</topic><topic>Glycated Hemoglobin A - metabolism</topic><topic>Gynecology. Andrology. Obstetrics</topic><topic>Humans</topic><topic>Medical sciences</topic><topic>Pregnancy</topic><topic>Pregnancy in Diabetics - blood</topic><topic>Pregnancy. Fetus. Placenta</topic><topic>Reference Values</topic><topic>Time Factors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>HILL, D. J</creatorcontrib><creatorcontrib>FLYVBJERG, A</creatorcontrib><creatorcontrib>ARANY, E</creatorcontrib><creatorcontrib>LAUSZUS, F. F</creatorcontrib><creatorcontrib>KLEBE, J. G</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>The journal of clinical endocrinology and metabolism</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>HILL, D. J</au><au>FLYVBJERG, A</au><au>ARANY, E</au><au>LAUSZUS, F. F</au><au>KLEBE, J. G</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Increased levels of serum fibroblast growth factor-2 in diabetic pregnant women with retinopathy</atitle><jtitle>The journal of clinical endocrinology and metabolism</jtitle><addtitle>J Clin Endocrinol Metab</addtitle><date>1997-05-01</date><risdate>1997</risdate><volume>82</volume><issue>5</issue><spage>1452</spage><epage>1457</epage><pages>1452-1457</pages><issn>0021-972X</issn><eissn>1945-7197</eissn><coden>JCEMAZ</coden><abstract>Fibroblast growth factor-2 (FGF-2) is a potent mitogen and angiogenic factor normally absent from the adult circulation. We have previously shown that it appears in normal maternal serum and that circulating FGF-2 levels are elevated in pregnancies complicated by diabetes. This study was performed to determine whether serum FGF-2 is more abundant in pregnant diabetic women with retinopathy than in those without. Serum was collected monthly between 14-30 weeks gestation and every 2 weeks from then until delivery (35-38 weeks) from 36 women with type 1 diabetes. FGF-2 was extracted by heparin-Sepharose affinity chromatography and quantified by specific RIA. Patients were divided according to the White classification of diabetes. In 17 women without retinopathy (White groups B, C, and D0), immunoreactive FGF-2 was detectable at 14 weeks (mean +/- SEM, 154 +/- 39 pmol/L), was maximal after 26 weeks (306 +/- 38 pmol/L), after which values steadily declined to term (212 +/- 48 pmol/L). In 19 women with simplex or proliferative retinopathy (White groups D+ and R), circulating levels of FGF-2 were significantly greater between 22-32 weeks gestation (22 weeks, 480 +/- 102 vs. 239 +/- 38 pmol/L; P < 0.05). Serum FGF-2 was significantly correlated with hemoglobin A1c levels at 22, 30, and 34 weeks gestation. The mean birth weight of the infants did not significantly differ between groups. Macroalbuminuria was absent in all patients, and creatinine clearance and blood pressure did not significantly differ between the two groups. The results suggest that serum FGF-2 is substantially elevated in pregnant diabetic women with retinopathy in second and early third trimesters. It is unlikely that in these patients this was primarily due to altered FGF-2 clearance, but may relate to excessive production by the utero-placental compartment. The high circulating levels of FGF-2 may be causally related to the development of diabetic retinopathy.</abstract><cop>Bethesda, MD</cop><pub>Endocrine Society</pub><pmid>9141532</pmid><doi>10.1210/jc.82.5.1452</doi><tpages>6</tpages></addata></record> |
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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Oxford University Press Journals All Titles (1996-Current) |
| subjects | Adult Biological and medical sciences Blood Glucose - metabolism Diabetic Retinopathy - blood Diseases of mother, fetus and pregnancy Female Fibroblast Growth Factor 2 - blood Glycated Hemoglobin A - metabolism Gynecology. Andrology. Obstetrics Humans Medical sciences Pregnancy Pregnancy in Diabetics - blood Pregnancy. Fetus. Placenta Reference Values Time Factors |
| title | Increased levels of serum fibroblast growth factor-2 in diabetic pregnant women with retinopathy |
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