Direct evidence of high DNA binding activity of transcription factor AP‐1 in rheumatoid arthritis synovium

Objective. To investigate the possible activation of transcription factor AP‐1 in rheumatoid arthritis (RA) and its involvement in the pathogenesis of RA. Methods. Synovial tissues and peripheral blood samples were obtained from 25 patients with RA and 5 patients with osteoarthritis (OA) during arth...

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Veröffentlicht in:	Arthritis and rheumatism 1997-05, Vol.40 (5), p.912-918
Hauptverfasser:	Asahara, Hiroshi, Fujisawa, Koushi, Kobata, Tetsuji, Hasunuma, Tomoko, Maeda, Toshiro, Asanuma, Masato, Ogawa, Norio, Inoue, Hajime, Sumida, Takayuki, Nishioka, Kusuki
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Aged, 80 and over Arthritis, Rheumatoid - genetics Arthritis, Rheumatoid - metabolism Biological and medical sciences Biomarkers - analysis C-Reactive Protein - analysis Diseases of the osteoarticular system DNA-Binding Proteins - metabolism Female Gene Expression Humans Inflammatory joint diseases Male Medical sciences Middle Aged Osteoarthritis - genetics Osteoarthritis - metabolism Proto-Oncogene Proteins c-fos - genetics Proto-Oncogene Proteins c-jun - genetics Synovial Membrane - metabolism Synovial Membrane - pathology Transcription Factor AP-1 - metabolism
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