Interleukin-15 promotes angiogenesis in vivo
IL-15, a cytokine with biological functions on cells of lymphoid lineage similar to those of IL-2, mediates its activities through the beta and gamma chains of the IL-2/15R and its own alpha chain. Unlike IL-2, IL-15 also binds to endothelial cells with high affinity. We report here that IL-15 is a...
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| Veröffentlicht in: | Biochemical and biophysical research communications 1997-04, Vol.233 (1), p.231-237 |
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| container_title | Biochemical and biophysical research communications |
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| creator | Angiolillo, A L Kanegane, H Sgadari, C Reaman, G H Tosato, G |
| description | IL-15, a cytokine with biological functions on cells of lymphoid lineage similar to those of IL-2, mediates its activities through the beta and gamma chains of the IL-2/15R and its own alpha chain. Unlike IL-2, IL-15 also binds to endothelial cells with high affinity. We report here that IL-15 is a stimulator of angiogenesis in vivo. When injected subcutaneously into nude mice, IL-15 consistently induced neovascularization of Matrigel plugs. Endothelial cells were found to express the IL-15R alpha chain and the IL-2/15R beta and common gamma chains. IL-15 induced the rapid tyrosine phosphorylation of proteins in endothelial cells, but did not stimulate endothelial cell proliferation in vitro. These findings document a previously unrecognized biological property of IL-15 and emphasize the role of IL-15 as an important mediator outside the immune system. |
| doi_str_mv | 10.1006/bbrc.1997.6435 |
| format | Article |
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| ispartof | Biochemical and biophysical research communications, 1997-04, Vol.233 (1), p.231-237 |
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| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Animals Endothelium, Vascular - cytology Endothelium, Vascular - metabolism Female Interleukin-15 - physiology Mice Mice, Inbred BALB C Neovascularization, Physiologic - physiology Receptors, Interleukin-15 Receptors, Interleukin-2 - metabolism |
| title | Interleukin-15 promotes angiogenesis in vivo |
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