Evidence for multiple human T cell recognition sites on myelin basic protein
Myelin basic protein (BP)-specific T cell clones were used to study human T cell recognition sites on the BP molecule. Proliferation assays performed with a panel of xenogeneic BPs of known amino acid sequence and with large peptide fragments of human and guinea pig BPs demonstrated ten different pa...
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| Veröffentlicht in: | Journal of neuroimmunology 1989-06, Vol.23 (1), p.55-66 |
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| container_start_page | 55 |
| container_title | Journal of neuroimmunology |
| container_volume | 23 |
| creator | Richert, John R. Robinson, Eve D. Deibler, Gladys E. Martenson, Russell E. Dragovic, Ljubo J. Kies, Marian W. |
| description | Myelin basic protein (BP)-specific T cell clones were used to study human T cell recognition sites on the BP molecule. Proliferation assays performed with a panel of xenogeneic BPs of known amino acid sequence and with large peptide fragments of human and guinea pig BPs demonstrated ten different patterns of reactivity. The data provide evidence for at least four different human T cell epitopes within the C-terminal half of the BP molecule, three within the N-terminal half, and three located within the central portion of the molecule. The results indicate that attempts to inhibit anti-BP responses in vivo in an antigen-specific manner will require the suppression of multiple T cell populations. |
| doi_str_mv | 10.1016/0165-5728(89)90073-8 |
| format | Article |
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Proliferation assays performed with a panel of xenogeneic BPs of known amino acid sequence and with large peptide fragments of human and guinea pig BPs demonstrated ten different patterns of reactivity. The data provide evidence for at least four different human T cell epitopes within the C-terminal half of the BP molecule, three within the N-terminal half, and three located within the central portion of the molecule. The results indicate that attempts to inhibit anti-BP responses in vivo in an antigen-specific manner will require the suppression of multiple T cell populations.</description><identifier>ISSN: 0165-5728</identifier><identifier>EISSN: 1872-8421</identifier><identifier>DOI: 10.1016/0165-5728(89)90073-8</identifier><identifier>PMID: 2470781</identifier><identifier>CODEN: JNRIDW</identifier><language>eng</language><publisher>London: Elsevier B.V</publisher><subject>Amino Acid Sequence ; Animals ; Biological and medical sciences ; Cattle ; Chickens ; Clone Cells - analysis ; Clone Cells - immunology ; Epitope ; Guinea Pigs ; Humans ; Lymphocyte Activation ; Medical sciences ; Molecular Sequence Data ; Myelin basic protein ; Myelin Basic Protein - genetics ; Myelin Basic Protein - immunology ; Myelin Basic Protein - isolation & purification ; Nervous system involvement in other diseases. Miscellaneous ; Neurology ; Protein Conformation ; Rabbits ; Sequence Homology, Nucleic Acid ; Species Specificity ; T cell clone, human ; T-Lymphocytes - analysis ; T-Lymphocytes - immunology</subject><ispartof>Journal of neuroimmunology, 1989-06, Vol.23 (1), p.55-66</ispartof><rights>1989</rights><rights>1989 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c417t-db359abd02fe4f335f94969342dee1bdbb123e7156647a4f7148bfa78a49c8ae3</citedby><cites>FETCH-LOGICAL-c417t-db359abd02fe4f335f94969342dee1bdbb123e7156647a4f7148bfa78a49c8ae3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/0165-5728(89)90073-8$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=7258404$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/2470781$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Richert, John R.</creatorcontrib><creatorcontrib>Robinson, Eve D.</creatorcontrib><creatorcontrib>Deibler, Gladys E.</creatorcontrib><creatorcontrib>Martenson, Russell E.</creatorcontrib><creatorcontrib>Dragovic, Ljubo J.</creatorcontrib><creatorcontrib>Kies, Marian W.</creatorcontrib><title>Evidence for multiple human T cell recognition sites on myelin basic protein</title><title>Journal of neuroimmunology</title><addtitle>J Neuroimmunol</addtitle><description>Myelin basic protein (BP)-specific T cell clones were used to study human T cell recognition sites on the BP molecule. Proliferation assays performed with a panel of xenogeneic BPs of known amino acid sequence and with large peptide fragments of human and guinea pig BPs demonstrated ten different patterns of reactivity. The data provide evidence for at least four different human T cell epitopes within the C-terminal half of the BP molecule, three within the N-terminal half, and three located within the central portion of the molecule. The results indicate that attempts to inhibit anti-BP responses in vivo in an antigen-specific manner will require the suppression of multiple T cell populations.</description><subject>Amino Acid Sequence</subject><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Cattle</subject><subject>Chickens</subject><subject>Clone Cells - analysis</subject><subject>Clone Cells - immunology</subject><subject>Epitope</subject><subject>Guinea Pigs</subject><subject>Humans</subject><subject>Lymphocyte Activation</subject><subject>Medical sciences</subject><subject>Molecular Sequence Data</subject><subject>Myelin basic protein</subject><subject>Myelin Basic Protein - genetics</subject><subject>Myelin Basic Protein - immunology</subject><subject>Myelin Basic Protein - isolation & purification</subject><subject>Nervous system involvement in other diseases. Miscellaneous</subject><subject>Neurology</subject><subject>Protein Conformation</subject><subject>Rabbits</subject><subject>Sequence Homology, Nucleic Acid</subject><subject>Species Specificity</subject><subject>T cell clone, human</subject><subject>T-Lymphocytes - analysis</subject><subject>T-Lymphocytes - immunology</subject><issn>0165-5728</issn><issn>1872-8421</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1989</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkctKxDAUhoMoOl7eQCELEV1UkzRpko0gMl5gwM24Dml6opFexqQVfHtbZ5ilLkIC5zvn_HxB6JSSa0pocTMekQnJ1KXSV5oQmWdqB82okixTnNFdNNsiB-gwpQ9CqMi53kf7jEsiFZ2hxfwrVNA6wL6LuBnqPqxqwO9DY1u8xA7qGkdw3Vsb-tC1OIUeEh4fzTfUocWlTcHhVex6CO0x2vO2TnCyuY_Q68N8ef-ULV4en-_vFpnjVPZZVeZC27IizAP3eS685rrQOWcVAC2rsqQsB0lFUXBpuZeUq9JbqSzXTlnIj9DFeu6493OA1JsmpCmqbaEbkpFKa0EU_xekgvGiUGwE-Rp0sUspgjerGBobvw0lZrJtJpVmUmmUNr-2jRrbzjbzh7KBatu00TvWzzd1m5ytfbStC2mLSSYUJ1PM2zUGo7SvANEkF6ZPqcLovjdVF_7O8QODaJsJ</recordid><startdate>19890601</startdate><enddate>19890601</enddate><creator>Richert, John R.</creator><creator>Robinson, Eve D.</creator><creator>Deibler, Gladys E.</creator><creator>Martenson, Russell E.</creator><creator>Dragovic, Ljubo J.</creator><creator>Kies, Marian W.</creator><general>Elsevier B.V</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>7TK</scope><scope>H94</scope><scope>7X8</scope></search><sort><creationdate>19890601</creationdate><title>Evidence for multiple human T cell recognition sites on myelin basic protein</title><author>Richert, John R. ; Robinson, Eve D. ; Deibler, Gladys E. ; Martenson, Russell E. ; Dragovic, Ljubo J. ; Kies, Marian W.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c417t-db359abd02fe4f335f94969342dee1bdbb123e7156647a4f7148bfa78a49c8ae3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1989</creationdate><topic>Amino Acid Sequence</topic><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Cattle</topic><topic>Chickens</topic><topic>Clone Cells - analysis</topic><topic>Clone Cells - immunology</topic><topic>Epitope</topic><topic>Guinea Pigs</topic><topic>Humans</topic><topic>Lymphocyte Activation</topic><topic>Medical sciences</topic><topic>Molecular Sequence Data</topic><topic>Myelin basic protein</topic><topic>Myelin Basic Protein - genetics</topic><topic>Myelin Basic Protein - immunology</topic><topic>Myelin Basic Protein - isolation & purification</topic><topic>Nervous system involvement in other diseases. Miscellaneous</topic><topic>Neurology</topic><topic>Protein Conformation</topic><topic>Rabbits</topic><topic>Sequence Homology, Nucleic Acid</topic><topic>Species Specificity</topic><topic>T cell clone, human</topic><topic>T-Lymphocytes - analysis</topic><topic>T-Lymphocytes - immunology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Richert, John R.</creatorcontrib><creatorcontrib>Robinson, Eve D.</creatorcontrib><creatorcontrib>Deibler, Gladys E.</creatorcontrib><creatorcontrib>Martenson, Russell E.</creatorcontrib><creatorcontrib>Dragovic, Ljubo J.</creatorcontrib><creatorcontrib>Kies, Marian W.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of neuroimmunology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Richert, John R.</au><au>Robinson, Eve D.</au><au>Deibler, Gladys E.</au><au>Martenson, Russell E.</au><au>Dragovic, Ljubo J.</au><au>Kies, Marian W.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Evidence for multiple human T cell recognition sites on myelin basic protein</atitle><jtitle>Journal of neuroimmunology</jtitle><addtitle>J Neuroimmunol</addtitle><date>1989-06-01</date><risdate>1989</risdate><volume>23</volume><issue>1</issue><spage>55</spage><epage>66</epage><pages>55-66</pages><issn>0165-5728</issn><eissn>1872-8421</eissn><coden>JNRIDW</coden><abstract>Myelin basic protein (BP)-specific T cell clones were used to study human T cell recognition sites on the BP molecule. Proliferation assays performed with a panel of xenogeneic BPs of known amino acid sequence and with large peptide fragments of human and guinea pig BPs demonstrated ten different patterns of reactivity. The data provide evidence for at least four different human T cell epitopes within the C-terminal half of the BP molecule, three within the N-terminal half, and three located within the central portion of the molecule. The results indicate that attempts to inhibit anti-BP responses in vivo in an antigen-specific manner will require the suppression of multiple T cell populations.</abstract><cop>London</cop><cop>Amsterdam</cop><cop>New York, NY</cop><pub>Elsevier B.V</pub><pmid>2470781</pmid><doi>10.1016/0165-5728(89)90073-8</doi><tpages>12</tpages></addata></record> |
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| identifier | ISSN: 0165-5728 |
| ispartof | Journal of neuroimmunology, 1989-06, Vol.23 (1), p.55-66 |
| issn | 0165-5728 1872-8421 |
| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals Complete |
| subjects | Amino Acid Sequence Animals Biological and medical sciences Cattle Chickens Clone Cells - analysis Clone Cells - immunology Epitope Guinea Pigs Humans Lymphocyte Activation Medical sciences Molecular Sequence Data Myelin basic protein Myelin Basic Protein - genetics Myelin Basic Protein - immunology Myelin Basic Protein - isolation & purification Nervous system involvement in other diseases. Miscellaneous Neurology Protein Conformation Rabbits Sequence Homology, Nucleic Acid Species Specificity T cell clone, human T-Lymphocytes - analysis T-Lymphocytes - immunology |
| title | Evidence for multiple human T cell recognition sites on myelin basic protein |
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