Serum HDL cholesterol values are associated with apoB-containing lipoprotein metabolism and triglyceride-body fat interrelation in young Japanese men
Serum levels of total cholesterol, high density lipoprotein (HDL) cholesterol, triglyceride, apolipoprotein (apo) AI, ApoB, ApoE and body fat were measured in 226 fasting male Japanese college students aged 18 to 20 years. They were normolipidemic (total cholesterol: 169±31 mg/dl, triglyceride: 56±2...
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| Veröffentlicht in: | Atherosclerosis 1997-04, Vol.130 (1), p.93-100 |
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| creator | Kazumi, Tsutomu Kawaguchi, Akira Hozumi, Toshiki Ishida, Yoshihiko Yoshino, Gen |
| description | Serum levels of total cholesterol, high density lipoprotein (HDL) cholesterol, triglyceride, apolipoprotein (apo) AI, ApoB, ApoE and body fat were measured in 226 fasting male Japanese college students aged 18 to 20 years. They were normolipidemic (total cholesterol: 169±31 mg/dl, triglyceride: 56±25 mg/dl) and their HDL cholesterol concentrations were high (61±13 mg/dl). An HDL cholesterol value |
| doi_str_mv | 10.1016/S0021-9150(96)06049-2 |
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2) and greater percent body fat (20.2±6.2 vs. 16.2±4.2%) determined using a bioelectrical impedance analyzer. HDL cholesterol levels were much more strongly related to triglyceride (
r=−0.37) than was apoAI (
r=−0.13). In stepwise multiple regression analysis in 184 nonsmokers, apoE, apoB and fat mass explained 21% of apoAI variability. Triglyceride in addition to these three parameters explained 41% of HDL cholesterol variability. These results suggest that serum levels of HDL cholesterol are associated with metabolism of apoB-containing lipoproteins as well as triglyceride-body fat interrelationship.</description><identifier>ISSN: 0021-9150</identifier><identifier>EISSN: 1879-1484</identifier><identifier>DOI: 10.1016/S0021-9150(96)06049-2</identifier><identifier>PMID: 9126652</identifier><language>eng</language><publisher>Amsterdam: Elsevier Ireland Ltd</publisher><subject>Adipose Tissue - anatomy & histology ; Adolescent ; Adult ; ApoAI ; ApoB ; ApoE ; Apolipoprotein A-I - blood ; Apolipoproteins B - blood ; Biological and medical sciences ; Body Constitution ; Cholesterol - blood ; Cholesterol, HDL - blood ; Cholesterol, LDL - blood ; Female ; Fundamental and applied biological sciences. Psychology ; HDL cholesterol ; Humans ; Japan ; Lipids. Glycolipids ; Male ; Metabolisms and neurohumoral controls ; Percent body fat ; Triglyceride ; Triglycerides - blood ; Vertebrates: anatomy and physiology, studies on body, several organs or systems</subject><ispartof>Atherosclerosis, 1997-04, Vol.130 (1), p.93-100</ispartof><rights>1997 Elsevier Science Ireland Ltd</rights><rights>1997 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c389t-b9ee388036fdd472b2606f3b0ac0e7657368584050de683476f5d3f5f8c47d5b3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0021915096060492$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65534</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=2630958$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/9126652$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kazumi, Tsutomu</creatorcontrib><creatorcontrib>Kawaguchi, Akira</creatorcontrib><creatorcontrib>Hozumi, Toshiki</creatorcontrib><creatorcontrib>Ishida, Yoshihiko</creatorcontrib><creatorcontrib>Yoshino, Gen</creatorcontrib><title>Serum HDL cholesterol values are associated with apoB-containing lipoprotein metabolism and triglyceride-body fat interrelation in young Japanese men</title><title>Atherosclerosis</title><addtitle>Atherosclerosis</addtitle><description>Serum levels of total cholesterol, high density lipoprotein (HDL) cholesterol, triglyceride, apolipoprotein (apo) AI, ApoB, ApoE and body fat were measured in 226 fasting male Japanese college students aged 18 to 20 years. They were normolipidemic (total cholesterol: 169±31 mg/dl, triglyceride: 56±25 mg/dl) and their HDL cholesterol concentrations were high (61±13 mg/dl). An HDL cholesterol value <35 mg/dl was observed in only one student (0.4%). In contrast, 112 men (49.6%) had an HDL cholesterol level ≥60 mg/dl. Even in this normolipidemic group, as compared with students in a top HDL cholesterol tertile (HDL cholesterol; 75±9 mg/dl), students in a lower HDL cholesterol tertile (HDL cholesterol; 48±5 mg/dl) had significantly increased serum levels of LDL cholesterol (103±30 vs. 91±26 mg/dl), triglyceride (68±30 vs. 45±16 mg/dl) and apoB (83±20 vs 73±17 mg/dl). In addition, they had greater body mass index (23.2±3.6 vs. 20.6±2.5 kg/m
2) and greater percent body fat (20.2±6.2 vs. 16.2±4.2%) determined using a bioelectrical impedance analyzer. HDL cholesterol levels were much more strongly related to triglyceride (
r=−0.37) than was apoAI (
r=−0.13). In stepwise multiple regression analysis in 184 nonsmokers, apoE, apoB and fat mass explained 21% of apoAI variability. Triglyceride in addition to these three parameters explained 41% of HDL cholesterol variability. These results suggest that serum levels of HDL cholesterol are associated with metabolism of apoB-containing lipoproteins as well as triglyceride-body fat interrelationship.</description><subject>Adipose Tissue - anatomy & histology</subject><subject>Adolescent</subject><subject>Adult</subject><subject>ApoAI</subject><subject>ApoB</subject><subject>ApoE</subject><subject>Apolipoprotein A-I - blood</subject><subject>Apolipoproteins B - blood</subject><subject>Biological and medical sciences</subject><subject>Body Constitution</subject><subject>Cholesterol - blood</subject><subject>Cholesterol, HDL - blood</subject><subject>Cholesterol, LDL - blood</subject><subject>Female</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>HDL cholesterol</subject><subject>Humans</subject><subject>Japan</subject><subject>Lipids. Glycolipids</subject><subject>Male</subject><subject>Metabolisms and neurohumoral controls</subject><subject>Percent body fat</subject><subject>Triglyceride</subject><subject>Triglycerides - blood</subject><subject>Vertebrates: anatomy and physiology, studies on body, several organs or systems</subject><issn>0021-9150</issn><issn>1879-1484</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1997</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkc9u1DAQxiMEKtvCI1TyASF6CNiJ7dgnVMqfglbiUDhbjj1pjRw72E7RPgjvi9td7ZWTZc1vvpn5vqY5J_gtwYS_u8G4I60kDL-R_AJzTGXbPWk2RAyyJVTQp83miDxvTnP-hTGmAxEnzYkkHees2zR_byCtM7r-uEXmLnrIBVL06F77FTLSCZDOORqnC1j0x5U7pJf4oTUxFO2CC7fIuyUuKRZwAc1Q9Bi9yzPSwaKS3K3fGUjOQjtGu0OTLsiFOiOB18XFUH9oF9eq800vOkCGKhJeNM8m7TO8PLxnzc_Pn35cXbfb71--Xl1uW9MLWdpRAvRC4J5P1tKhGzuO-dSPWBsMA2dDzwUTFDNsgYueDnxitp_YJAwdLBv7s-b1Xrce8LseXNTssgHv6yZxzWoQUlJCeQXZHjQp5pxgUktys047RbB6iEM9xqEevFaSq8c4VFf7zg8D1nEGe-w6-F_rrw51nY32U9LBuHzEOt5jyUTF3u8xqGbcO0gqGwfBgHUJTFE2uv8s8g8TkKmi</recordid><startdate>19970401</startdate><enddate>19970401</enddate><creator>Kazumi, Tsutomu</creator><creator>Kawaguchi, Akira</creator><creator>Hozumi, Toshiki</creator><creator>Ishida, Yoshihiko</creator><creator>Yoshino, Gen</creator><general>Elsevier Ireland Ltd</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19970401</creationdate><title>Serum HDL cholesterol values are associated with apoB-containing lipoprotein metabolism and triglyceride-body fat interrelation in young Japanese men</title><author>Kazumi, Tsutomu ; Kawaguchi, Akira ; Hozumi, Toshiki ; Ishida, Yoshihiko ; Yoshino, Gen</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c389t-b9ee388036fdd472b2606f3b0ac0e7657368584050de683476f5d3f5f8c47d5b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1997</creationdate><topic>Adipose Tissue - anatomy & histology</topic><topic>Adolescent</topic><topic>Adult</topic><topic>ApoAI</topic><topic>ApoB</topic><topic>ApoE</topic><topic>Apolipoprotein A-I - blood</topic><topic>Apolipoproteins B - blood</topic><topic>Biological and medical sciences</topic><topic>Body Constitution</topic><topic>Cholesterol - blood</topic><topic>Cholesterol, HDL - blood</topic><topic>Cholesterol, LDL - blood</topic><topic>Female</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>HDL cholesterol</topic><topic>Humans</topic><topic>Japan</topic><topic>Lipids. Glycolipids</topic><topic>Male</topic><topic>Metabolisms and neurohumoral controls</topic><topic>Percent body fat</topic><topic>Triglyceride</topic><topic>Triglycerides - blood</topic><topic>Vertebrates: anatomy and physiology, studies on body, several organs or systems</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kazumi, Tsutomu</creatorcontrib><creatorcontrib>Kawaguchi, Akira</creatorcontrib><creatorcontrib>Hozumi, Toshiki</creatorcontrib><creatorcontrib>Ishida, Yoshihiko</creatorcontrib><creatorcontrib>Yoshino, Gen</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Atherosclerosis</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kazumi, Tsutomu</au><au>Kawaguchi, Akira</au><au>Hozumi, Toshiki</au><au>Ishida, Yoshihiko</au><au>Yoshino, Gen</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Serum HDL cholesterol values are associated with apoB-containing lipoprotein metabolism and triglyceride-body fat interrelation in young Japanese men</atitle><jtitle>Atherosclerosis</jtitle><addtitle>Atherosclerosis</addtitle><date>1997-04-01</date><risdate>1997</risdate><volume>130</volume><issue>1</issue><spage>93</spage><epage>100</epage><pages>93-100</pages><issn>0021-9150</issn><eissn>1879-1484</eissn><abstract>Serum levels of total cholesterol, high density lipoprotein (HDL) cholesterol, triglyceride, apolipoprotein (apo) AI, ApoB, ApoE and body fat were measured in 226 fasting male Japanese college students aged 18 to 20 years. They were normolipidemic (total cholesterol: 169±31 mg/dl, triglyceride: 56±25 mg/dl) and their HDL cholesterol concentrations were high (61±13 mg/dl). An HDL cholesterol value <35 mg/dl was observed in only one student (0.4%). In contrast, 112 men (49.6%) had an HDL cholesterol level ≥60 mg/dl. Even in this normolipidemic group, as compared with students in a top HDL cholesterol tertile (HDL cholesterol; 75±9 mg/dl), students in a lower HDL cholesterol tertile (HDL cholesterol; 48±5 mg/dl) had significantly increased serum levels of LDL cholesterol (103±30 vs. 91±26 mg/dl), triglyceride (68±30 vs. 45±16 mg/dl) and apoB (83±20 vs 73±17 mg/dl). In addition, they had greater body mass index (23.2±3.6 vs. 20.6±2.5 kg/m
2) and greater percent body fat (20.2±6.2 vs. 16.2±4.2%) determined using a bioelectrical impedance analyzer. HDL cholesterol levels were much more strongly related to triglyceride (
r=−0.37) than was apoAI (
r=−0.13). In stepwise multiple regression analysis in 184 nonsmokers, apoE, apoB and fat mass explained 21% of apoAI variability. Triglyceride in addition to these three parameters explained 41% of HDL cholesterol variability. These results suggest that serum levels of HDL cholesterol are associated with metabolism of apoB-containing lipoproteins as well as triglyceride-body fat interrelationship.</abstract><cop>Amsterdam</cop><pub>Elsevier Ireland Ltd</pub><pmid>9126652</pmid><doi>10.1016/S0021-9150(96)06049-2</doi><tpages>8</tpages></addata></record> |
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| ispartof | Atherosclerosis, 1997-04, Vol.130 (1), p.93-100 |
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| subjects | Adipose Tissue - anatomy & histology Adolescent Adult ApoAI ApoB ApoE Apolipoprotein A-I - blood Apolipoproteins B - blood Biological and medical sciences Body Constitution Cholesterol - blood Cholesterol, HDL - blood Cholesterol, LDL - blood Female Fundamental and applied biological sciences. Psychology HDL cholesterol Humans Japan Lipids. Glycolipids Male Metabolisms and neurohumoral controls Percent body fat Triglyceride Triglycerides - blood Vertebrates: anatomy and physiology, studies on body, several organs or systems |
| title | Serum HDL cholesterol values are associated with apoB-containing lipoprotein metabolism and triglyceride-body fat interrelation in young Japanese men |
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