Analysis of the large (L) protein gene of the porcine rubulavirus LPMV: identification of possible functional domains
The complete nucleotide sequence of the porcine rubulavirus LPMV (La Piedad Michoacan virus) large (L) protein gene was determined and analysed. The L mRNA was found to span 6,786 nucleotides, containing one single large open reading frame (ORF), putatively encoding a polypeptide of 2,251 amino acid...
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| Veröffentlicht in: | Virus research 1997-04, Vol.48 (1), p.57-70 |
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| container_title | Virus research |
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| creator | Svenda, M. (Swedish Univ. of Agricultural Sciences, Uppsala (Sweden). Dept. of Veterinary Microbiology) Berg, M Moreno-Lopez, J Linne, T |
| description | The complete nucleotide sequence of the porcine rubulavirus LPMV (La Piedad Michoacan virus) large (L) protein gene was determined and analysed. The L mRNA was found to span 6,786 nucleotides, containing one single large open reading frame (ORF), putatively encoding a polypeptide of 2,251 amino acids. By aligning the amino acid sequence of the LPMV L-protein with L-protein of a number of viruses belonging to the order mononegavirale, a high degree of similarity between the LPMV L-protein and other rubula virus L-proteins was demonstrated, extending through almost the whole protein. Additionally we could identify several regions as being highly conserved among all studied viruses of the order mononegavirale. The significance of these regions are discussed. |
| doi_str_mv | 10.1016/S0168-1702(96)01426-8 |
| format | Article |
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(Swedish Univ. of Agricultural Sciences, Uppsala (Sweden). Dept. of Veterinary Microbiology) ; Berg, M ; Moreno-Lopez, J ; Linne, T</creator><creatorcontrib>Svenda, M. (Swedish Univ. of Agricultural Sciences, Uppsala (Sweden). Dept. of Veterinary Microbiology) ; Berg, M ; Moreno-Lopez, J ; Linne, T</creatorcontrib><description>The complete nucleotide sequence of the porcine rubulavirus LPMV (La Piedad Michoacan virus) large (L) protein gene was determined and analysed. The L mRNA was found to span 6,786 nucleotides, containing one single large open reading frame (ORF), putatively encoding a polypeptide of 2,251 amino acids. By aligning the amino acid sequence of the LPMV L-protein with L-protein of a number of viruses belonging to the order mononegavirale, a high degree of similarity between the LPMV L-protein and other rubula virus L-proteins was demonstrated, extending through almost the whole protein. Additionally we could identify several regions as being highly conserved among all studied viruses of the order mononegavirale. 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(Swedish Univ. of Agricultural Sciences, Uppsala (Sweden). Dept. of Veterinary Microbiology)</creatorcontrib><creatorcontrib>Berg, M</creatorcontrib><creatorcontrib>Moreno-Lopez, J</creatorcontrib><creatorcontrib>Linne, T</creatorcontrib><title>Analysis of the large (L) protein gene of the porcine rubulavirus LPMV: identification of possible functional domains</title><title>Virus research</title><addtitle>Virus Res</addtitle><description>The complete nucleotide sequence of the porcine rubulavirus LPMV (La Piedad Michoacan virus) large (L) protein gene was determined and analysed. The L mRNA was found to span 6,786 nucleotides, containing one single large open reading frame (ORF), putatively encoding a polypeptide of 2,251 amino acids. By aligning the amino acid sequence of the LPMV L-protein with L-protein of a number of viruses belonging to the order mononegavirale, a high degree of similarity between the LPMV L-protein and other rubula virus L-proteins was demonstrated, extending through almost the whole protein. Additionally we could identify several regions as being highly conserved among all studied viruses of the order mononegavirale. The significance of these regions are discussed.</description><subject>Amino Acid Sequence</subject><subject>Animals</subject><subject>Base Sequence</subject><subject>Binding Sites</subject><subject>CERDO</subject><subject>DNA, Viral</subject><subject>GENE</subject><subject>GENES</subject><subject>Genes, Viral</subject><subject>Humans</subject><subject>Molecular Sequence Data</subject><subject>NUCLEOTIDE SEQUENCE</subject><subject>PARAMYXOVIRIDAE</subject><subject>Phylogeny</subject><subject>PORCIN</subject><subject>porcine rubulavirus</subject><subject>PROTEINAS</subject><subject>PROTEINE</subject><subject>PROTEINS</subject><subject>RNA Viruses - genetics</subject><subject>Rubulavirus - classification</subject><subject>Rubulavirus - genetics</subject><subject>SECUENCIA NUCLEOTIDICA</subject><subject>Sequence Homology, Amino Acid</subject><subject>SEQUENCE NUCLEOTIDIQUE</subject><subject>SWINE</subject><subject>Swine - virology</subject><subject>Viral Proteins - genetics</subject><issn>0168-1702</issn><issn>1872-7492</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1997</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkElPwzAQhS0EKqXwEyr5hOghMHYSL9yqik0Ki8RyjWzHKUZZip0g9d-TigLHXmY08z6N3huEpgTOCRB28TwUEREO9EyyGZCEskjsoTERnEY8kXQfjf-QQ3QUwgcAsJizERpJkgCRyRj180ZV6-ACbkvcvVtcKb-0-Cyb4ZVvO-savLSN_VVXrTduGH2v-0p9Od8HnD3dv11iV9imc6UzqnNts-FXbQhOVxaXfWM2S1Xhoq2Va8IxOihVFezJtk_Q6_XVy-I2yh5v7hbzLCqphC6KU0sNjZWgIlWQFlKVIKXVLNXASTFESAsRF5yJOLGaEFMaA5JqAaC1UiaeoNOfu0OWz96GLq9dMLaqVGPbPuRcSBkzkewECQOWSBC7wVQywgkfwOkW7HVti3zlXa38Ot9-_l8vVZurpXchf8iIlIN3kIOjb5kpj2w</recordid><startdate>19970401</startdate><enddate>19970401</enddate><creator>Svenda, M. 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By aligning the amino acid sequence of the LPMV L-protein with L-protein of a number of viruses belonging to the order mononegavirale, a high degree of similarity between the LPMV L-protein and other rubula virus L-proteins was demonstrated, extending through almost the whole protein. Additionally we could identify several regions as being highly conserved among all studied viruses of the order mononegavirale. The significance of these regions are discussed.</abstract><cop>Netherlands</cop><pmid>9140194</pmid><doi>10.1016/S0168-1702(96)01426-8</doi><tpages>14</tpages></addata></record> |
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| ispartof | Virus research, 1997-04, Vol.48 (1), p.57-70 |
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| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals Complete |
| subjects | Amino Acid Sequence Animals Base Sequence Binding Sites CERDO DNA, Viral GENE GENES Genes, Viral Humans Molecular Sequence Data NUCLEOTIDE SEQUENCE PARAMYXOVIRIDAE Phylogeny PORCIN porcine rubulavirus PROTEINAS PROTEINE PROTEINS RNA Viruses - genetics Rubulavirus - classification Rubulavirus - genetics SECUENCIA NUCLEOTIDICA Sequence Homology, Amino Acid SEQUENCE NUCLEOTIDIQUE SWINE Swine - virology Viral Proteins - genetics |
| title | Analysis of the large (L) protein gene of the porcine rubulavirus LPMV: identification of possible functional domains |
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