Effects of glycyrrhizin on immune-mediated cytotoxicity
Intravenous administration of glycyrrhizin is known to decrease elevated plasma transaminase levels in patients with chronic viral hepatitis, in which immune‐mediated cytotoxicity by cytotoxic T lymphocytes and tumour necrosis factor (TNF)‐α is considered to play an important pathogenic role. Howeve...
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| Veröffentlicht in: | Journal of gastroenterology and hepatology 1997-03, Vol.12 (3), p.243-248 |
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| creator | YOSHIKAWA, MASAHIDE MATSUI, YUJI KAWAMOTO, HIROSHI UMEMOTO, NORIE OKU, KAZUMI KOIZUMI, MASAKI YAMAO, JUNICHI KURIYAMA, SHIGEKI NAKANO, HIROSHI HOZUMI, NOBUMICHI ISHIZAKA, SHIGEAKI FUKUI, HIROSHI |
| description | Intravenous administration of glycyrrhizin is known to decrease elevated plasma transaminase levels in patients with chronic viral hepatitis, in which immune‐mediated cytotoxicity by cytotoxic T lymphocytes and tumour necrosis factor (TNF)‐α is considered to play an important pathogenic role. However, the immunological interpretation of the transaminase‐lowering action of glycyrrhizin is not known. Studies were performed to elucidate this action immunologically by assessing the effects of glycyrrhizin on immune‐mediated cytotoxicity using an antigen‐specific murine CD4+ T hybridoma line, which exhibits cytotoxicity against antigen‐presenting cells after stimulation with specific antigen, and a murine TNF‐α‐sensitive fibroblast line. Glycyrrhizin inhibited the cytotoxic activity of the T cells against antigen‐presenting cells and also suppressed TNF‐α‐induced cytotoxicity in the TNF‐α‐sensitive cell line in vitro. These results suggest that the decrease of elevated transaminase levels by glycyrrhizin in patients with chronic viral hepatitis is mediated in part by inhibition of immune‐mediated cytotoxicity against hepatocytes. |
| doi_str_mv | 10.1111/j.1440-1746.1997.tb00416.x |
| format | Article |
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However, the immunological interpretation of the transaminase‐lowering action of glycyrrhizin is not known. Studies were performed to elucidate this action immunologically by assessing the effects of glycyrrhizin on immune‐mediated cytotoxicity using an antigen‐specific murine CD4+ T hybridoma line, which exhibits cytotoxicity against antigen‐presenting cells after stimulation with specific antigen, and a murine TNF‐α‐sensitive fibroblast line. Glycyrrhizin inhibited the cytotoxic activity of the T cells against antigen‐presenting cells and also suppressed TNF‐α‐induced cytotoxicity in the TNF‐α‐sensitive cell line in vitro. These results suggest that the decrease of elevated transaminase levels by glycyrrhizin in patients with chronic viral hepatitis is mediated in part by inhibition of immune‐mediated cytotoxicity against hepatocytes.</description><identifier>ISSN: 0815-9319</identifier><identifier>EISSN: 1440-1746</identifier><identifier>DOI: 10.1111/j.1440-1746.1997.tb00416.x</identifier><identifier>PMID: 9142643</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Publishing Ltd</publisher><subject>Animals ; Antibody-Dependent Cell Cytotoxicity - drug effects ; antigen presentation ; apoptosis ; Biological and medical sciences ; CD4+ Tlymphocyte ; CD4-Positive T-Lymphocytes - drug effects ; Cell Line ; Chromium - metabolism ; Chromium Radioisotopes ; Fibroblasts - drug effects ; Gastroenterology. Liver. Pancreas. Abdomen ; Glycyrrhetinic Acid - analogs & derivatives ; Glycyrrhetinic Acid - pharmacology ; Glycyrrhizic Acid ; glycyrrhizin ; Humans ; Liver. Biliary tract. Portal circulation. Exocrine pancreas ; Medical sciences ; Mice ; Other diseases. 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However, the immunological interpretation of the transaminase‐lowering action of glycyrrhizin is not known. Studies were performed to elucidate this action immunologically by assessing the effects of glycyrrhizin on immune‐mediated cytotoxicity using an antigen‐specific murine CD4+ T hybridoma line, which exhibits cytotoxicity against antigen‐presenting cells after stimulation with specific antigen, and a murine TNF‐α‐sensitive fibroblast line. Glycyrrhizin inhibited the cytotoxic activity of the T cells against antigen‐presenting cells and also suppressed TNF‐α‐induced cytotoxicity in the TNF‐α‐sensitive cell line in vitro. These results suggest that the decrease of elevated transaminase levels by glycyrrhizin in patients with chronic viral hepatitis is mediated in part by inhibition of immune‐mediated cytotoxicity against hepatocytes.</description><subject>Animals</subject><subject>Antibody-Dependent Cell Cytotoxicity - drug effects</subject><subject>antigen presentation</subject><subject>apoptosis</subject><subject>Biological and medical sciences</subject><subject>CD4+ Tlymphocyte</subject><subject>CD4-Positive T-Lymphocytes - drug effects</subject><subject>Cell Line</subject><subject>Chromium - metabolism</subject><subject>Chromium Radioisotopes</subject><subject>Fibroblasts - drug effects</subject><subject>Gastroenterology. Liver. Pancreas. Abdomen</subject><subject>Glycyrrhetinic Acid - analogs & derivatives</subject><subject>Glycyrrhetinic Acid - pharmacology</subject><subject>Glycyrrhizic Acid</subject><subject>glycyrrhizin</subject><subject>Humans</subject><subject>Liver. Biliary tract. Portal circulation. Exocrine pancreas</subject><subject>Medical sciences</subject><subject>Mice</subject><subject>Other diseases. Semiology</subject><subject>T cell-mediated cytotoxicity</subject><subject>T-Lymphocytes, Cytotoxic - drug effects</subject><subject>Tumor Cells, Cultured</subject><subject>Tumor Necrosis Factor-alpha - pharmacology</subject><subject>tumour necrosis factor-α</subject><issn>0815-9319</issn><issn>1440-1746</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1997</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqVkEtPGzEURq2qFQ2Pn1BpVFXdzdTXz3EXlaoIQisEGxASG8s4NnU6D7AnIsOvxyGj7PHCXnznPnwQ-gq4gnx-rCpgDJcgmahAKVkN9xgzENXmA5rto49ohmvgpaKgPqPDlFY4U1jyA3SggBHB6AzJU--dHVLR--KhGe0Y47_wErqi74rQtuvOla1bBjO4ZWHHoR_6TbBhGI_RJ2-a5E6m9wjdnJ1ez8_Li6vFn_nvi9JyTGhJlfPSYcLrJatrKZ1SFogBxZnjYCxgvsT5rl0tiLGE1iIznHvPPAMM9Ah93_V9jP3T2qVBtyFZ1zSmc_06aVkrRTmRGfy5A23sU4rO68cYWhNHDVhvremV3qrRWzV6a01P1vQmF3-Zpqzv83f3pZOmnH-bcpOsaXw0nQ1pjxEBjEqRsV877Dk0bnzHAvrv4py8zSl3DUIa3GbfwMT_Wkgqub69XOg7fCYIcKnv6CvXNZcD</recordid><startdate>199703</startdate><enddate>199703</enddate><creator>YOSHIKAWA, MASAHIDE</creator><creator>MATSUI, YUJI</creator><creator>KAWAMOTO, HIROSHI</creator><creator>UMEMOTO, NORIE</creator><creator>OKU, KAZUMI</creator><creator>KOIZUMI, MASAKI</creator><creator>YAMAO, JUNICHI</creator><creator>KURIYAMA, SHIGEKI</creator><creator>NAKANO, HIROSHI</creator><creator>HOZUMI, NOBUMICHI</creator><creator>ISHIZAKA, SHIGEAKI</creator><creator>FUKUI, HIROSHI</creator><general>Blackwell Publishing Ltd</general><general>Blackwell Science</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>199703</creationdate><title>Effects of glycyrrhizin on immune-mediated cytotoxicity</title><author>YOSHIKAWA, MASAHIDE ; MATSUI, YUJI ; KAWAMOTO, HIROSHI ; UMEMOTO, NORIE ; OKU, KAZUMI ; KOIZUMI, MASAKI ; YAMAO, JUNICHI ; KURIYAMA, SHIGEKI ; NAKANO, HIROSHI ; HOZUMI, NOBUMICHI ; ISHIZAKA, SHIGEAKI ; FUKUI, HIROSHI</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5023-39ef7e0258d48877e99c12a1954e51ac105d0c108e862ac23867e955ff4f41013</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1997</creationdate><topic>Animals</topic><topic>Antibody-Dependent Cell Cytotoxicity - drug effects</topic><topic>antigen presentation</topic><topic>apoptosis</topic><topic>Biological and medical sciences</topic><topic>CD4+ Tlymphocyte</topic><topic>CD4-Positive T-Lymphocytes - drug effects</topic><topic>Cell Line</topic><topic>Chromium - metabolism</topic><topic>Chromium Radioisotopes</topic><topic>Fibroblasts - drug effects</topic><topic>Gastroenterology. Liver. Pancreas. Abdomen</topic><topic>Glycyrrhetinic Acid - analogs & derivatives</topic><topic>Glycyrrhetinic Acid - pharmacology</topic><topic>Glycyrrhizic Acid</topic><topic>glycyrrhizin</topic><topic>Humans</topic><topic>Liver. Biliary tract. Portal circulation. Exocrine pancreas</topic><topic>Medical sciences</topic><topic>Mice</topic><topic>Other diseases. 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However, the immunological interpretation of the transaminase‐lowering action of glycyrrhizin is not known. Studies were performed to elucidate this action immunologically by assessing the effects of glycyrrhizin on immune‐mediated cytotoxicity using an antigen‐specific murine CD4+ T hybridoma line, which exhibits cytotoxicity against antigen‐presenting cells after stimulation with specific antigen, and a murine TNF‐α‐sensitive fibroblast line. Glycyrrhizin inhibited the cytotoxic activity of the T cells against antigen‐presenting cells and also suppressed TNF‐α‐induced cytotoxicity in the TNF‐α‐sensitive cell line in vitro. These results suggest that the decrease of elevated transaminase levels by glycyrrhizin in patients with chronic viral hepatitis is mediated in part by inhibition of immune‐mediated cytotoxicity against hepatocytes.</abstract><cop>Oxford, UK</cop><pub>Blackwell Publishing Ltd</pub><pmid>9142643</pmid><doi>10.1111/j.1440-1746.1997.tb00416.x</doi><tpages>6</tpages></addata></record> |
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| identifier | ISSN: 0815-9319 |
| ispartof | Journal of gastroenterology and hepatology, 1997-03, Vol.12 (3), p.243-248 |
| issn | 0815-9319 1440-1746 |
| language | eng |
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| source | Wiley Online Library - AutoHoldings Journals; MEDLINE |
| subjects | Animals Antibody-Dependent Cell Cytotoxicity - drug effects antigen presentation apoptosis Biological and medical sciences CD4+ Tlymphocyte CD4-Positive T-Lymphocytes - drug effects Cell Line Chromium - metabolism Chromium Radioisotopes Fibroblasts - drug effects Gastroenterology. Liver. Pancreas. Abdomen Glycyrrhetinic Acid - analogs & derivatives Glycyrrhetinic Acid - pharmacology Glycyrrhizic Acid glycyrrhizin Humans Liver. Biliary tract. Portal circulation. Exocrine pancreas Medical sciences Mice Other diseases. Semiology T cell-mediated cytotoxicity T-Lymphocytes, Cytotoxic - drug effects Tumor Cells, Cultured Tumor Necrosis Factor-alpha - pharmacology tumour necrosis factor-α |
| title | Effects of glycyrrhizin on immune-mediated cytotoxicity |
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