MK-386, an inhibitor of 5alpha-reductase type 1, reduces dihydrotestosterone concentrations in serum and sebum without affecting dihydrotestosterone concentrations in semen

Two isozymes (types 1 and 2) of 5alpha-reductase (5alphaR; EC 1.3.99.5), with differential tissue distribution, catalyze the reduction of testosterone (T) to dihydrotestosterone (DHT) in humans. This study examined sequentially increasing oral doses of MK-386 (4,7beta-dimethyl-4-aza-5alpha-cholestan...

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Veröffentlicht in:	The journal of clinical endocrinology and metabolism 1997-05, Vol.82 (5), p.1373-1377
Hauptverfasser:	Schwartz, J I, Tanaka, W K, Wang, D Z, Ebel, D L, Geissler, L A, Dallob, A, Hafkin, B, Gertz, B J
Format:	Artikel
Sprache:	eng
Schlagworte:	5-alpha Reductase Inhibitors Adolescent Adult Androstane-3,17-diol - analogs & derivatives Androstane-3,17-diol - blood Azasteroids - pharmacology Dihydrotestosterone - blood Dihydrotestosterone - metabolism Enzyme Inhibitors - pharmacology Finasteride - pharmacology Humans Luteinizing Hormone - blood Male Middle Aged Sebum - metabolism Semen - metabolism Testosterone - blood
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