A novel peptide, pyroglutamylglutamylproline amide, in the rabbit prostate complex, structurally related to thyrotrophin-releasing hormone
A novel peptide which cross-reacts with an antibody to thyrotrophin-releasing hormone has been isolated and characterized from the rabbit prostate complex. The peptide exhibited an amino acid composition of Glx1.7, Pro1.0, and automatic gas phase sequence analysis after mild acid hydrolysis establis...
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| Veröffentlicht in: | The Journal of biological chemistry 1989-05, Vol.264 (14), p.7788-7791 |
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| container_issue | 14 |
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| container_title | The Journal of biological chemistry |
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| creator | Cockle, S M Aitken, A Beg, F Smyth, D G |
| description | A novel peptide which cross-reacts with an antibody to thyrotrophin-releasing hormone has been isolated and characterized from the rabbit prostate complex. The peptide exhibited an amino acid composition of Glx1.7, Pro1.0, and automatic gas phase sequence analysis after mild acid hydrolysis established the sequence Glu-Glu-Pro. Fast atom bombardment mass spectrometry gave a pseudomolecular ion (M + H)+ of 355.2 confirming that the prostate peptide has the structure of pGlu-Glu-Pro-NH2. This peptide differs from authentic thyrotrophin-releasing hormone by the substitution of glutamic acid for histidine at position 2. |
| doi_str_mv | 10.1016/S0021-9258(18)83109-X |
| format | Article |
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The peptide exhibited an amino acid composition of Glx1.7, Pro1.0, and automatic gas phase sequence analysis after mild acid hydrolysis established the sequence Glu-Glu-Pro. Fast atom bombardment mass spectrometry gave a pseudomolecular ion (M + H)+ of 355.2 confirming that the prostate peptide has the structure of pGlu-Glu-Pro-NH2. This peptide differs from authentic thyrotrophin-releasing hormone by the substitution of glutamic acid for histidine at position 2.</description><identifier>ISSN: 0021-9258</identifier><identifier>EISSN: 1083-351X</identifier><identifier>DOI: 10.1016/S0021-9258(18)83109-X</identifier><identifier>PMID: 2498305</identifier><identifier>CODEN: JBCHA3</identifier><language>eng</language><publisher>Bethesda, MD: Elsevier Inc</publisher><subject>Amino Acid Sequence ; Amino Acids - analysis ; Aminoacids, peptides. Hormones. Neuropeptides ; Analytical, structural and metabolic biochemistry ; Animals ; Biological and medical sciences ; Chromatography, High Pressure Liquid ; Chromatography, Ion Exchange ; Fundamental and applied biological sciences. Psychology ; Immunoassay ; Male ; Mass Spectrometry ; Molecular Sequence Data ; Molecular Weight ; Oligopeptides - analysis ; Prostate - analysis ; Protein Precursors ; Proteins ; Pyrrolidonecarboxylic Acid - analogs & derivatives ; Rabbits ; Thyrotropin-Releasing Hormone - analysis</subject><ispartof>The Journal of biological chemistry, 1989-05, Vol.264 (14), p.7788-7791</ispartof><rights>1989 © 1989 ASBMB. 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The peptide exhibited an amino acid composition of Glx1.7, Pro1.0, and automatic gas phase sequence analysis after mild acid hydrolysis established the sequence Glu-Glu-Pro. Fast atom bombardment mass spectrometry gave a pseudomolecular ion (M + H)+ of 355.2 confirming that the prostate peptide has the structure of pGlu-Glu-Pro-NH2. This peptide differs from authentic thyrotrophin-releasing hormone by the substitution of glutamic acid for histidine at position 2.</description><subject>Amino Acid Sequence</subject><subject>Amino Acids - analysis</subject><subject>Aminoacids, peptides. Hormones. Neuropeptides</subject><subject>Analytical, structural and metabolic biochemistry</subject><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Chromatography, High Pressure Liquid</subject><subject>Chromatography, Ion Exchange</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Immunoassay</subject><subject>Male</subject><subject>Mass Spectrometry</subject><subject>Molecular Sequence Data</subject><subject>Molecular Weight</subject><subject>Oligopeptides - analysis</subject><subject>Prostate - analysis</subject><subject>Protein Precursors</subject><subject>Proteins</subject><subject>Pyrrolidonecarboxylic Acid - analogs & derivatives</subject><subject>Rabbits</subject><subject>Thyrotropin-Releasing Hormone - analysis</subject><issn>0021-9258</issn><issn>1083-351X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1989</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkduKFDEQhoMo67r6CAsBRRS2NelTkitZFk-w4IUKcxdyqJ6OpDttkl6dV_Cpzc6Mc2tuCvJ_f6XyF0KXlLyhhPZvvxJS00rUHX9F-WveUCKqzQN0Tglvqqajm4fo_IQ8Rk9S-kHKaQU9Q2d1K3hDunP05xrP4Q48XmDJzsIVXnYxbP2a1bTz_-oSg3czYDXtETfjPAKOSmuXcRFTVhmwCdPi4fcVTjmuJq9Reb_DEXwRLc6hmErvHMMyurkq96CSm7d4DHEKMzxFjwblEzw71gv0_cP7bzefqtsvHz_fXN9Wpu3bXDHRa61sYxQD0g6CMiMIJYYxK5hSgtlaE1ErUVtDNekM19oMA-mF5gRa21ygl4e-ZfCfK6QsJ5cMeK9mCGuSjAtRs5YWsDuApvwwRRjkEt2k4k5SIu93IPc7kPcBS8rlfgdyU3yXxwdWPYE9uY6hF_3FUVfJKD9ENRuXThhrmo71pGDPD9jotuMvF0FqF8wIk6z7VtJWMsZ5od4dKCiR3TmIMhkHswFbHCZLG9x_xv0L_Vqz2Q</recordid><startdate>19890515</startdate><enddate>19890515</enddate><creator>Cockle, S M</creator><creator>Aitken, A</creator><creator>Beg, F</creator><creator>Smyth, D G</creator><general>Elsevier Inc</general><general>American Society for Biochemistry and Molecular Biology</general><scope>6I.</scope><scope>AAFTH</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19890515</creationdate><title>A novel peptide, pyroglutamylglutamylproline amide, in the rabbit prostate complex, structurally related to thyrotrophin-releasing hormone</title><author>Cockle, S M ; Aitken, A ; Beg, F ; Smyth, D G</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c464t-796bbad3ca7e04f917c9010c77d97aa97d2b092a92dc1b05c8bbcff069b80e4d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1989</creationdate><topic>Amino Acid Sequence</topic><topic>Amino Acids - analysis</topic><topic>Aminoacids, peptides. 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Psychology</topic><topic>Immunoassay</topic><topic>Male</topic><topic>Mass Spectrometry</topic><topic>Molecular Sequence Data</topic><topic>Molecular Weight</topic><topic>Oligopeptides - analysis</topic><topic>Prostate - analysis</topic><topic>Protein Precursors</topic><topic>Proteins</topic><topic>Pyrrolidonecarboxylic Acid - analogs & derivatives</topic><topic>Rabbits</topic><topic>Thyrotropin-Releasing Hormone - analysis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Cockle, S M</creatorcontrib><creatorcontrib>Aitken, A</creatorcontrib><creatorcontrib>Beg, F</creatorcontrib><creatorcontrib>Smyth, D G</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>The Journal of biological chemistry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Cockle, S M</au><au>Aitken, A</au><au>Beg, F</au><au>Smyth, D G</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A novel peptide, pyroglutamylglutamylproline amide, in the rabbit prostate complex, structurally related to thyrotrophin-releasing hormone</atitle><jtitle>The Journal of biological chemistry</jtitle><addtitle>J Biol Chem</addtitle><date>1989-05-15</date><risdate>1989</risdate><volume>264</volume><issue>14</issue><spage>7788</spage><epage>7791</epage><pages>7788-7791</pages><issn>0021-9258</issn><eissn>1083-351X</eissn><coden>JBCHA3</coden><abstract>A novel peptide which cross-reacts with an antibody to thyrotrophin-releasing hormone has been isolated and characterized from the rabbit prostate complex. The peptide exhibited an amino acid composition of Glx1.7, Pro1.0, and automatic gas phase sequence analysis after mild acid hydrolysis established the sequence Glu-Glu-Pro. Fast atom bombardment mass spectrometry gave a pseudomolecular ion (M + H)+ of 355.2 confirming that the prostate peptide has the structure of pGlu-Glu-Pro-NH2. This peptide differs from authentic thyrotrophin-releasing hormone by the substitution of glutamic acid for histidine at position 2.</abstract><cop>Bethesda, MD</cop><pub>Elsevier Inc</pub><pmid>2498305</pmid><doi>10.1016/S0021-9258(18)83109-X</doi><tpages>4</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | The Journal of biological chemistry, 1989-05, Vol.264 (14), p.7788-7791 |
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| language | eng |
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| source | MEDLINE; EZB-FREE-00999 freely available EZB journals; Alma/SFX Local Collection |
| subjects | Amino Acid Sequence Amino Acids - analysis Aminoacids, peptides. Hormones. Neuropeptides Analytical, structural and metabolic biochemistry Animals Biological and medical sciences Chromatography, High Pressure Liquid Chromatography, Ion Exchange Fundamental and applied biological sciences. Psychology Immunoassay Male Mass Spectrometry Molecular Sequence Data Molecular Weight Oligopeptides - analysis Prostate - analysis Protein Precursors Proteins Pyrrolidonecarboxylic Acid - analogs & derivatives Rabbits Thyrotropin-Releasing Hormone - analysis |
| title | A novel peptide, pyroglutamylglutamylproline amide, in the rabbit prostate complex, structurally related to thyrotrophin-releasing hormone |
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