Measurement of nitric oxide in the rat cerebral cortex during hypercapnoea
CHANGES in nitric oxide (NO) concentration and cerebral blood flow (CBF) in the parietal cortex during hypercapnoea were investigated in anaesthetized rats, using a NO-selective electrode and laser Doppler flowmetry. When hypercapnoea was induced by inhalation of 5% CO2 for 10 min, both the NO conce...
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| Veröffentlicht in: | Neuroreport 1997-03, Vol.8 (4), p.999-1002 |
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| creator | Harada, Masato Fuse, Akihisa Tanaka, Yoshifumi |
| description | CHANGES in nitric oxide (NO) concentration and cerebral blood flow (CBF) in the parietal cortex during hypercapnoea were investigated in anaesthetized rats, using a NO-selective electrode and laser Doppler flowmetry. When hypercapnoea was induced by inhalation of 5% CO2 for 10 min, both the NO concentration and CBF increased. After administration of 7-nitroindazole, a neuronal NO synthase (nNOS) inhibitor, both the basal NO and CBF decreased, and responses to hypercapnoea were also significantly suppressed by 70.1% and 73.2%, respectively, compared with the control state. These results suggest that NO derived from nNOS is involved not only in maintaining resting cerebral circulation but also in regulating CBF response during hypercapnoea. |
| doi_str_mv | 10.1097/00001756-199703030-00036 |
| format | Article |
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When hypercapnoea was induced by inhalation of 5% CO2 for 10 min, both the NO concentration and CBF increased. After administration of 7-nitroindazole, a neuronal NO synthase (nNOS) inhibitor, both the basal NO and CBF decreased, and responses to hypercapnoea were also significantly suppressed by 70.1% and 73.2%, respectively, compared with the control state. These results suggest that NO derived from nNOS is involved not only in maintaining resting cerebral circulation but also in regulating CBF response during hypercapnoea.</description><identifier>ISSN: 0959-4965</identifier><identifier>EISSN: 1473-558X</identifier><identifier>DOI: 10.1097/00001756-199703030-00036</identifier><identifier>PMID: 9141080</identifier><language>eng</language><publisher>Hagerstown, MD: Lippincott-Raven Publishers</publisher><subject>Animals ; Biochemistry and metabolism ; Biological and medical sciences ; Carbon Dioxide - blood ; Central nervous system ; Cerebral Cortex - blood supply ; Cerebral Cortex - metabolism ; Cerebrovascular Circulation - drug effects ; Enzyme Inhibitors - pharmacology ; Fundamental and applied biological sciences. Psychology ; Hypercapnia - metabolism ; Hypercapnia - physiopathology ; Indazoles - pharmacology ; Laser-Doppler Flowmetry ; Male ; Nitric Oxide - metabolism ; Nitric Oxide Synthase - antagonists & inhibitors ; Rats ; Rats, Wistar ; Regional Blood Flow - drug effects ; Vertebrates: nervous system and sense organs</subject><ispartof>Neuroreport, 1997-03, Vol.8 (4), p.999-1002</ispartof><rights>Lippincott-Raven Publishers.</rights><rights>1997 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4156-1572002c37fcacc07a47124c81c63f7edf4253ff9cc94bdb562e4d3c7d5048253</citedby><cites>FETCH-LOGICAL-c4156-1572002c37fcacc07a47124c81c63f7edf4253ff9cc94bdb562e4d3c7d5048253</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=2648186$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/9141080$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Harada, Masato</creatorcontrib><creatorcontrib>Fuse, Akihisa</creatorcontrib><creatorcontrib>Tanaka, Yoshifumi</creatorcontrib><title>Measurement of nitric oxide in the rat cerebral cortex during hypercapnoea</title><title>Neuroreport</title><addtitle>Neuroreport</addtitle><description>CHANGES in nitric oxide (NO) concentration and cerebral blood flow (CBF) in the parietal cortex during hypercapnoea were investigated in anaesthetized rats, using a NO-selective electrode and laser Doppler flowmetry. When hypercapnoea was induced by inhalation of 5% CO2 for 10 min, both the NO concentration and CBF increased. After administration of 7-nitroindazole, a neuronal NO synthase (nNOS) inhibitor, both the basal NO and CBF decreased, and responses to hypercapnoea were also significantly suppressed by 70.1% and 73.2%, respectively, compared with the control state. These results suggest that NO derived from nNOS is involved not only in maintaining resting cerebral circulation but also in regulating CBF response during hypercapnoea.</description><subject>Animals</subject><subject>Biochemistry and metabolism</subject><subject>Biological and medical sciences</subject><subject>Carbon Dioxide - blood</subject><subject>Central nervous system</subject><subject>Cerebral Cortex - blood supply</subject><subject>Cerebral Cortex - metabolism</subject><subject>Cerebrovascular Circulation - drug effects</subject><subject>Enzyme Inhibitors - pharmacology</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Hypercapnia - metabolism</subject><subject>Hypercapnia - physiopathology</subject><subject>Indazoles - pharmacology</subject><subject>Laser-Doppler Flowmetry</subject><subject>Male</subject><subject>Nitric Oxide - metabolism</subject><subject>Nitric Oxide Synthase - antagonists & inhibitors</subject><subject>Rats</subject><subject>Rats, Wistar</subject><subject>Regional Blood Flow - drug effects</subject><subject>Vertebrates: nervous system and sense organs</subject><issn>0959-4965</issn><issn>1473-558X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1997</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkctu2zAQRYkihes8PiEAF0V2akiKz2VhJG0DB900QHYEPRrGamXJJSXY_vvKteNdEM6CAO-dO8QZQihnXzhz5paNhxulC-6cYeVYxfhS6g9kyqUpC6Xs8xmZMqdcIZ1Wn8h5zr9Hi2PcTsjEccmZZVPy8IghDwlX2Pa0i7St-1QD7bZ1hbRuab9EmkJPARMuUmgodKnHLa2GVLcvdLlbY4KwbjsMl-RjDE3Gq-N9QZ7u737Nvhfzn99-zL7OC5B8_2NlBGMCShMhADATpOFCguWgy2iwilKoMkYH4OSiWigtUFYlmEoxaUfpgtwcctep-ztg7v2qzoBNE1rshuyNdU4Iqd81cs2Z0HyfaA9GSF3OCaNfp3oV0s5z5ve8_Stvf-Lt__MeW6-PM4bFCqtT4xHwqH8-6iFDaGIKLdT5ZBNaWm73MfJg23RNjyn_aYYNJr_E0PRL_9a2y39Il5bf</recordid><startdate>19970303</startdate><enddate>19970303</enddate><creator>Harada, Masato</creator><creator>Fuse, Akihisa</creator><creator>Tanaka, Yoshifumi</creator><general>Lippincott-Raven Publishers</general><general>Lippincott Williams and Wilkins</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>7X8</scope></search><sort><creationdate>19970303</creationdate><title>Measurement of nitric oxide in the rat cerebral cortex during hypercapnoea</title><author>Harada, Masato ; Fuse, Akihisa ; Tanaka, Yoshifumi</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4156-1572002c37fcacc07a47124c81c63f7edf4253ff9cc94bdb562e4d3c7d5048253</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1997</creationdate><topic>Animals</topic><topic>Biochemistry and metabolism</topic><topic>Biological and medical sciences</topic><topic>Carbon Dioxide - blood</topic><topic>Central nervous system</topic><topic>Cerebral Cortex - blood supply</topic><topic>Cerebral Cortex - metabolism</topic><topic>Cerebrovascular Circulation - drug effects</topic><topic>Enzyme Inhibitors - pharmacology</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Hypercapnia - metabolism</topic><topic>Hypercapnia - physiopathology</topic><topic>Indazoles - pharmacology</topic><topic>Laser-Doppler Flowmetry</topic><topic>Male</topic><topic>Nitric Oxide - metabolism</topic><topic>Nitric Oxide Synthase - antagonists & inhibitors</topic><topic>Rats</topic><topic>Rats, Wistar</topic><topic>Regional Blood Flow - drug effects</topic><topic>Vertebrates: nervous system and sense organs</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Harada, Masato</creatorcontrib><creatorcontrib>Fuse, Akihisa</creatorcontrib><creatorcontrib>Tanaka, Yoshifumi</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Neuroreport</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Harada, Masato</au><au>Fuse, Akihisa</au><au>Tanaka, Yoshifumi</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Measurement of nitric oxide in the rat cerebral cortex during hypercapnoea</atitle><jtitle>Neuroreport</jtitle><addtitle>Neuroreport</addtitle><date>1997-03-03</date><risdate>1997</risdate><volume>8</volume><issue>4</issue><spage>999</spage><epage>1002</epage><pages>999-1002</pages><issn>0959-4965</issn><eissn>1473-558X</eissn><abstract>CHANGES in nitric oxide (NO) concentration and cerebral blood flow (CBF) in the parietal cortex during hypercapnoea were investigated in anaesthetized rats, using a NO-selective electrode and laser Doppler flowmetry. When hypercapnoea was induced by inhalation of 5% CO2 for 10 min, both the NO concentration and CBF increased. After administration of 7-nitroindazole, a neuronal NO synthase (nNOS) inhibitor, both the basal NO and CBF decreased, and responses to hypercapnoea were also significantly suppressed by 70.1% and 73.2%, respectively, compared with the control state. These results suggest that NO derived from nNOS is involved not only in maintaining resting cerebral circulation but also in regulating CBF response during hypercapnoea.</abstract><cop>Hagerstown, MD</cop><pub>Lippincott-Raven Publishers</pub><pmid>9141080</pmid><doi>10.1097/00001756-199703030-00036</doi><tpages>4</tpages></addata></record> |
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| subjects | Animals Biochemistry and metabolism Biological and medical sciences Carbon Dioxide - blood Central nervous system Cerebral Cortex - blood supply Cerebral Cortex - metabolism Cerebrovascular Circulation - drug effects Enzyme Inhibitors - pharmacology Fundamental and applied biological sciences. Psychology Hypercapnia - metabolism Hypercapnia - physiopathology Indazoles - pharmacology Laser-Doppler Flowmetry Male Nitric Oxide - metabolism Nitric Oxide Synthase - antagonists & inhibitors Rats Rats, Wistar Regional Blood Flow - drug effects Vertebrates: nervous system and sense organs |
| title | Measurement of nitric oxide in the rat cerebral cortex during hypercapnoea |
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