Subgenual prefrontal cortex abnormalities in mood disorders
Pathological disturbances of mood may follow a 'bipolar' course, in which normal moods alternate with both depression and mania, or a 'unipolar' course, in which only depression occurs 1–3 . Both bipolar and unipolar disorders can be heritable illnesses associated with neurochemi...
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| Veröffentlicht in: | Nature (London) 1997-04, Vol.386 (6627), p.824-827 |
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| creator | Drevets, Wayne C. Price, Joseph L. Simpson, Joseph R. Todd, Richard D. Reich, Theodore Vannier, Michael Raichle, Marcus E. |
| description | Pathological disturbances of mood may follow a 'bipolar' course, in which normal moods alternate with both depression and mania, or a 'unipolar' course, in which only depression occurs
1–3
. Both bipolar and unipolar disorders can be heritable illnesses associated with neurochemical, neuroendocrine and autonomic abnormalities. The neurobiological basis for these abnormalities has not been established
2,3
. Using positron emission tomographic (PET) images of cerebral blood flow and rate of glucose metabolism to measure brain activity, we have now localized an area of abnormally decreased activity in the pre-frontal cortex ventral to the genu of the corpus callosum in both familial bipolar depressives and familial unipolar depressives. This decrement in activity was at least partly explained by a corresponding reduction in cortical volume
4
, as magnetic resonance imaging (MRI) demonstrated reductions in the mean grey matter volume in the same area of 39 and 48% in the bipolar and unipolar samples, respectively. This region has previously been implicated in the mediation of emotional and autonomic responses to socially significant or provocative stimuli, and in the modulation of the neurotransmitter systems targeted by antidepressant drugs
3,5–10
. |
| doi_str_mv | 10.1038/386824a0 |
| format | Article |
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1–3
. Both bipolar and unipolar disorders can be heritable illnesses associated with neurochemical, neuroendocrine and autonomic abnormalities. The neurobiological basis for these abnormalities has not been established
2,3
. Using positron emission tomographic (PET) images of cerebral blood flow and rate of glucose metabolism to measure brain activity, we have now localized an area of abnormally decreased activity in the pre-frontal cortex ventral to the genu of the corpus callosum in both familial bipolar depressives and familial unipolar depressives. This decrement in activity was at least partly explained by a corresponding reduction in cortical volume
4
, as magnetic resonance imaging (MRI) demonstrated reductions in the mean grey matter volume in the same area of 39 and 48% in the bipolar and unipolar samples, respectively. This region has previously been implicated in the mediation of emotional and autonomic responses to socially significant or provocative stimuli, and in the modulation of the neurotransmitter systems targeted by antidepressant drugs
3,5–10
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1–3
. Both bipolar and unipolar disorders can be heritable illnesses associated with neurochemical, neuroendocrine and autonomic abnormalities. The neurobiological basis for these abnormalities has not been established
2,3
. Using positron emission tomographic (PET) images of cerebral blood flow and rate of glucose metabolism to measure brain activity, we have now localized an area of abnormally decreased activity in the pre-frontal cortex ventral to the genu of the corpus callosum in both familial bipolar depressives and familial unipolar depressives. This decrement in activity was at least partly explained by a corresponding reduction in cortical volume
4
, as magnetic resonance imaging (MRI) demonstrated reductions in the mean grey matter volume in the same area of 39 and 48% in the bipolar and unipolar samples, respectively. This region has previously been implicated in the mediation of emotional and autonomic responses to socially significant or provocative stimuli, and in the modulation of the neurotransmitter systems targeted by antidepressant drugs
3,5–10
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Academic</collection><jtitle>Nature (London)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Drevets, Wayne C.</au><au>Price, Joseph L.</au><au>Simpson, Joseph R.</au><au>Todd, Richard D.</au><au>Reich, Theodore</au><au>Vannier, Michael</au><au>Raichle, Marcus E.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Subgenual prefrontal cortex abnormalities in mood disorders</atitle><jtitle>Nature (London)</jtitle><stitle>Nature</stitle><addtitle>Nature</addtitle><date>1997-04-24</date><risdate>1997</risdate><volume>386</volume><issue>6627</issue><spage>824</spage><epage>827</epage><pages>824-827</pages><issn>0028-0836</issn><eissn>1476-4687</eissn><coden>NATUAS</coden><abstract>Pathological disturbances of mood may follow a 'bipolar' course, in which normal moods alternate with both depression and mania, or a 'unipolar' course, in which only depression occurs
1–3
. Both bipolar and unipolar disorders can be heritable illnesses associated with neurochemical, neuroendocrine and autonomic abnormalities. The neurobiological basis for these abnormalities has not been established
2,3
. Using positron emission tomographic (PET) images of cerebral blood flow and rate of glucose metabolism to measure brain activity, we have now localized an area of abnormally decreased activity in the pre-frontal cortex ventral to the genu of the corpus callosum in both familial bipolar depressives and familial unipolar depressives. This decrement in activity was at least partly explained by a corresponding reduction in cortical volume
4
, as magnetic resonance imaging (MRI) demonstrated reductions in the mean grey matter volume in the same area of 39 and 48% in the bipolar and unipolar samples, respectively. This region has previously been implicated in the mediation of emotional and autonomic responses to socially significant or provocative stimuli, and in the modulation of the neurotransmitter systems targeted by antidepressant drugs
3,5–10
.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>9126739</pmid><doi>10.1038/386824a0</doi><tpages>4</tpages></addata></record> |
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| language | eng |
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| source | MEDLINE; Nature; SpringerLink Journals - AutoHoldings |
| subjects | Adult Adult and adolescent clinical studies Affect Biological and medical sciences Bipolar Disorder - pathology Bipolar disorders Blood Brain Case-Control Studies Depressive Disorder - pathology Emissions Female Glucose - metabolism Humanities and Social Sciences Humans letter Magnetic Resonance Imaging Male Medical research Medical sciences Mental depression Mental disorders Mood disorders multidisciplinary Nervous system Prefrontal Cortex - blood supply Prefrontal Cortex - metabolism Prefrontal Cortex - pathology Psychology. Psychoanalysis. Psychiatry Psychopathology. Psychiatry Science Science (multidisciplinary) Tomography, Emission-Computed |
| title | Subgenual prefrontal cortex abnormalities in mood disorders |
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