Antimalarial activity of new water-soluble dihydroartemisinin derivatives. 2. Stereospecificity of the ether side chain

A new series of hydrolytically stable and water-soluble dihydroartemisinin derivatives with optically active side chains was prepared as potential antimalarial agents. This was an effort to prepare compounds with activity superior to that of artelinic acid and to examine the impact of the stereospec...

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Veröffentlicht in:	Journal of medicinal chemistry 1989-06, Vol.32 (6), p.1249-1252
Hauptverfasser:	Lin, Ai Jeng, Lee, Margaret, Klayman, Daniel L
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Artemisinins Chemical Phenomena Chemistry Malaria - drug therapy Mice Molecular Structure Plasmodium falciparum Plasmodium falciparum - drug effects Sesquiterpenes - chemical synthesis Sesquiterpenes - pharmacology Sesquiterpenes - therapeutic use Solubility Stereoisomerism Structure-Activity Relationship Water
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