Murine interleukin-4 displays potent anti-tumor activity in vivo
We have devised a sensitive means to assess the anti-tumor effect of cytokines that act via the mobilization of host-mediated defenses. This assay involves transfecting malignant cells to produce a specific cytokine (in this case, IL-4) and measuring the ability of transfectants to form tumors alone...
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| Veröffentlicht in: | Cell 1989-05, Vol.57 (3), p.503-512 |
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| container_title | Cell |
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| creator | Tepper, Robert I. Pattengale, Paul K. Leder, Philip |
| description | We have devised a sensitive means to assess the anti-tumor effect of cytokines that act via the mobilization of host-mediated defenses. This assay involves transfecting malignant cells to produce a specific cytokine (in this case, IL-4) and measuring the ability of transfectants to form tumors alone and when mixed with a variety of nontransfected tumor cells. In this way, we have identified a potent, non-cell autonomous, anti-tumor effect of IL-4 which is effective against a wide range of tumor cell types in vivo. The effect is reversed by anti-IL-4 antibody, correlates closely with levels of IL-4 production, and is evident in
nu
nu
mice. The anti-tumor effect seems to be mediated by an inflammatory infiltrate composed of eosinophils and macrophages. |
| doi_str_mv | 10.1016/0092-8674(89)90925-2 |
| format | Article |
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nu
nu
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nu
nu
mice. The anti-tumor effect seems to be mediated by an inflammatory infiltrate composed of eosinophils and macrophages.</description><subject>Adenocarcinoma - genetics</subject><subject>Adenocarcinoma - metabolism</subject><subject>Adenocarcinoma - pathology</subject><subject>Analysis of the immune response. Humoral and cellular immunity</subject><subject>Animals</subject><subject>Antibodies - immunology</subject><subject>Antineoplastic Agents - metabolism</subject><subject>Antineoplastic Agents - pharmacology</subject><subject>Biological and medical sciences</subject><subject>Cell Line</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Fundamental immunology</subject><subject>Gene Expression Regulation</subject><subject>Immunobiology</subject><subject>Interleukin-4</subject><subject>Interleukins - genetics</subject><subject>Interleukins - metabolism</subject><subject>Interleukins - physiology</subject><subject>Lymphokines, interleukins ( function, expression)</subject><subject>Mice</subject><subject>Mice, Inbred BALB C</subject><subject>Neoplasm Transplantation</subject><subject>Plasmacytoma - genetics</subject><subject>Plasmacytoma - metabolism</subject><subject>Plasmacytoma - pathology</subject><subject>Regulatory factors and their cellular receptors</subject><subject>Transfection</subject><subject>Tumor Cells, Cultured</subject><issn>0092-8674</issn><issn>1097-4172</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1989</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkE1LxDAQhoMo67r6DxR6ENFDdZI0bXoRRfwCxYuew2w6hWi3XZN0Yf-9XXfZo56GYZ53ZngYO-ZwyYHnVwClSHVeZOe6vCiHRqVih405lEWa8ULssvEW2WcHIXwCgFZKjdhIFFpplY_ZzWvvXUuJayP5hvov16ZZUrkwb3AZknkXqY0JttGlsZ91PkEb3cLF5ZBIFm7RHbK9GptAR5s6YR8P9-93T-nL2-Pz3e1LaqUUMSUsETi3UxBcUVbllZCScrISAepaSDvFmkSOeYkapECEukKeUyVQZTCVE3a23jv33XdPIZqZC5aaBlvq-mAKXepCKf4vyJXMCilWYLYGre9C8FSbuXcz9EvDwawMm5U-s9JndGl-DRsxxE42-_vpjKptaKN0mJ9u5hgsNrXH1rqwxYbToDkM2PUao0HawpE3wTpqLVXOk42m6tzff_wAUuqXeQ</recordid><startdate>19890505</startdate><enddate>19890505</enddate><creator>Tepper, Robert I.</creator><creator>Pattengale, Paul K.</creator><creator>Leder, Philip</creator><general>Elsevier Inc</general><general>Cell Press</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>H94</scope><scope>7X8</scope></search><sort><creationdate>19890505</creationdate><title>Murine interleukin-4 displays potent anti-tumor activity in vivo</title><author>Tepper, Robert I. ; Pattengale, Paul K. ; Leder, Philip</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c332t-ea9a011cb0215e4d6d233e6ec3a00ff23cbafe26a69a8032aa0fda16ed2a540b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1989</creationdate><topic>Adenocarcinoma - genetics</topic><topic>Adenocarcinoma - metabolism</topic><topic>Adenocarcinoma - pathology</topic><topic>Analysis of the immune response. Humoral and cellular immunity</topic><topic>Animals</topic><topic>Antibodies - immunology</topic><topic>Antineoplastic Agents - metabolism</topic><topic>Antineoplastic Agents - pharmacology</topic><topic>Biological and medical sciences</topic><topic>Cell Line</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Fundamental immunology</topic><topic>Gene Expression Regulation</topic><topic>Immunobiology</topic><topic>Interleukin-4</topic><topic>Interleukins - genetics</topic><topic>Interleukins - metabolism</topic><topic>Interleukins - physiology</topic><topic>Lymphokines, interleukins ( function, expression)</topic><topic>Mice</topic><topic>Mice, Inbred BALB C</topic><topic>Neoplasm Transplantation</topic><topic>Plasmacytoma - genetics</topic><topic>Plasmacytoma - metabolism</topic><topic>Plasmacytoma - pathology</topic><topic>Regulatory factors and their cellular receptors</topic><topic>Transfection</topic><topic>Tumor Cells, Cultured</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Tepper, Robert I.</creatorcontrib><creatorcontrib>Pattengale, Paul K.</creatorcontrib><creatorcontrib>Leder, Philip</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Cell</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Tepper, Robert I.</au><au>Pattengale, Paul K.</au><au>Leder, Philip</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Murine interleukin-4 displays potent anti-tumor activity in vivo</atitle><jtitle>Cell</jtitle><addtitle>Cell</addtitle><date>1989-05-05</date><risdate>1989</risdate><volume>57</volume><issue>3</issue><spage>503</spage><epage>512</epage><pages>503-512</pages><issn>0092-8674</issn><eissn>1097-4172</eissn><coden>CELLB5</coden><abstract>We have devised a sensitive means to assess the anti-tumor effect of cytokines that act via the mobilization of host-mediated defenses. This assay involves transfecting malignant cells to produce a specific cytokine (in this case, IL-4) and measuring the ability of transfectants to form tumors alone and when mixed with a variety of nontransfected tumor cells. In this way, we have identified a potent, non-cell autonomous, anti-tumor effect of IL-4 which is effective against a wide range of tumor cell types in vivo. The effect is reversed by anti-IL-4 antibody, correlates closely with levels of IL-4 production, and is evident in
nu
nu
mice. The anti-tumor effect seems to be mediated by an inflammatory infiltrate composed of eosinophils and macrophages.</abstract><cop>Cambridge, MA</cop><pub>Elsevier Inc</pub><pmid>2785856</pmid><doi>10.1016/0092-8674(89)90925-2</doi><tpages>10</tpages></addata></record> |
| fulltext | fulltext |
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| ispartof | Cell, 1989-05, Vol.57 (3), p.503-512 |
| issn | 0092-8674 1097-4172 |
| language | eng |
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| source | MEDLINE; ScienceDirect Journals (5 years ago - present) |
| subjects | Adenocarcinoma - genetics Adenocarcinoma - metabolism Adenocarcinoma - pathology Analysis of the immune response. Humoral and cellular immunity Animals Antibodies - immunology Antineoplastic Agents - metabolism Antineoplastic Agents - pharmacology Biological and medical sciences Cell Line Fundamental and applied biological sciences. Psychology Fundamental immunology Gene Expression Regulation Immunobiology Interleukin-4 Interleukins - genetics Interleukins - metabolism Interleukins - physiology Lymphokines, interleukins ( function, expression) Mice Mice, Inbred BALB C Neoplasm Transplantation Plasmacytoma - genetics Plasmacytoma - metabolism Plasmacytoma - pathology Regulatory factors and their cellular receptors Transfection Tumor Cells, Cultured |
| title | Murine interleukin-4 displays potent anti-tumor activity in vivo |
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