The antiarrhythmic activity of N-alkyl-1,2-diphenylethanolamines
The activity of N-alkyl-1,2-diphenylethanolamines against CaCl2-induced cardiac arrhythmia was evaluated in the rat. The potencies of the compounds were compared with that of the established calcium ion-channel blocker, verapamil. The N-methyl, N-ethyl, and N-isobutyl derivatives as well as verapami...
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| Veröffentlicht in: | Pharmaceutical research 1989-03, Vol.6 (3), p.252-254 |
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| container_title | Pharmaceutical research |
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| creator | EL TAHIR, K. E. H AL-OBEID, H. A AL-RASHOOD, K. A MADANI, A. A. E AGEEL, A. M |
| description | The activity of N-alkyl-1,2-diphenylethanolamines against CaCl2-induced cardiac arrhythmia was evaluated in the rat. The potencies of the compounds were compared with that of the established calcium ion-channel blocker, verapamil. The N-methyl, N-ethyl, and N-isobutyl derivatives as well as verapamil at doses of 2-8 mumols kg-1 protected the animals against the induced arrhythmia. The potency order was verapamil greater than N methyl greater than N-ethyl greater than N-isobutyl derivatives. The N-isopropyl and N-butyl derivatives were inactive. The antiarrhythmic activity of the compounds was not due to local anesthetic activity but may be caused by calcium-channel inhibition. |
| doi_str_mv | 10.1023/A:1015925803166 |
| format | Article |
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E. H ; AL-OBEID, H. A ; AL-RASHOOD, K. A ; MADANI, A. A. E ; AGEEL, A. M</creator><creatorcontrib>EL TAHIR, K. E. H ; AL-OBEID, H. A ; AL-RASHOOD, K. A ; MADANI, A. A. E ; AGEEL, A. M</creatorcontrib><description>The activity of N-alkyl-1,2-diphenylethanolamines against CaCl2-induced cardiac arrhythmia was evaluated in the rat. The potencies of the compounds were compared with that of the established calcium ion-channel blocker, verapamil. The N-methyl, N-ethyl, and N-isobutyl derivatives as well as verapamil at doses of 2-8 mumols kg-1 protected the animals against the induced arrhythmia. The potency order was verapamil greater than N methyl greater than N-ethyl greater than N-isobutyl derivatives. The N-isopropyl and N-butyl derivatives were inactive. The antiarrhythmic activity of the compounds was not due to local anesthetic activity but may be caused by calcium-channel inhibition.</description><identifier>ISSN: 0724-8741</identifier><identifier>EISSN: 1573-904X</identifier><identifier>DOI: 10.1023/A:1015925803166</identifier><identifier>PMID: 2726684</identifier><identifier>CODEN: PHREEB</identifier><language>eng</language><publisher>New York, NY: Springer</publisher><subject>Animals ; Anti-Arrhythmia Agents - pharmacology ; Antiarythmic agents ; Biological and medical sciences ; Cardiovascular system ; Chemical Phenomena ; Chemistry ; Ethanolamines - pharmacology ; Lidocaine - pharmacology ; Male ; Medical sciences ; Pharmacology. 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A</creatorcontrib><creatorcontrib>AL-RASHOOD, K. A</creatorcontrib><creatorcontrib>MADANI, A. A. E</creatorcontrib><creatorcontrib>AGEEL, A. M</creatorcontrib><title>The antiarrhythmic activity of N-alkyl-1,2-diphenylethanolamines</title><title>Pharmaceutical research</title><addtitle>Pharm Res</addtitle><description>The activity of N-alkyl-1,2-diphenylethanolamines against CaCl2-induced cardiac arrhythmia was evaluated in the rat. The potencies of the compounds were compared with that of the established calcium ion-channel blocker, verapamil. The N-methyl, N-ethyl, and N-isobutyl derivatives as well as verapamil at doses of 2-8 mumols kg-1 protected the animals against the induced arrhythmia. The potency order was verapamil greater than N methyl greater than N-ethyl greater than N-isobutyl derivatives. The N-isopropyl and N-butyl derivatives were inactive. The antiarrhythmic activity of the compounds was not due to local anesthetic activity but may be caused by calcium-channel inhibition.</description><subject>Animals</subject><subject>Anti-Arrhythmia Agents - pharmacology</subject><subject>Antiarythmic agents</subject><subject>Biological and medical sciences</subject><subject>Cardiovascular system</subject><subject>Chemical Phenomena</subject><subject>Chemistry</subject><subject>Ethanolamines - pharmacology</subject><subject>Lidocaine - pharmacology</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Pharmacology. 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A</creatorcontrib><creatorcontrib>MADANI, A. A. E</creatorcontrib><creatorcontrib>AGEEL, A. M</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>Pharmaceutical research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>EL TAHIR, K. E. H</au><au>AL-OBEID, H. A</au><au>AL-RASHOOD, K. A</au><au>MADANI, A. A. E</au><au>AGEEL, A. M</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The antiarrhythmic activity of N-alkyl-1,2-diphenylethanolamines</atitle><jtitle>Pharmaceutical research</jtitle><addtitle>Pharm Res</addtitle><date>1989-03-01</date><risdate>1989</risdate><volume>6</volume><issue>3</issue><spage>252</spage><epage>254</epage><pages>252-254</pages><issn>0724-8741</issn><eissn>1573-904X</eissn><coden>PHREEB</coden><abstract>The activity of N-alkyl-1,2-diphenylethanolamines against CaCl2-induced cardiac arrhythmia was evaluated in the rat. The potencies of the compounds were compared with that of the established calcium ion-channel blocker, verapamil. The N-methyl, N-ethyl, and N-isobutyl derivatives as well as verapamil at doses of 2-8 mumols kg-1 protected the animals against the induced arrhythmia. The potency order was verapamil greater than N methyl greater than N-ethyl greater than N-isobutyl derivatives. The N-isopropyl and N-butyl derivatives were inactive. The antiarrhythmic activity of the compounds was not due to local anesthetic activity but may be caused by calcium-channel inhibition.</abstract><cop>New York, NY</cop><pub>Springer</pub><pmid>2726684</pmid><doi>10.1023/A:1015925803166</doi><tpages>3</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0724-8741 |
| ispartof | Pharmaceutical research, 1989-03, Vol.6 (3), p.252-254 |
| issn | 0724-8741 1573-904X |
| language | eng |
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| source | MEDLINE; Springer Nature - Complete Springer Journals |
| subjects | Animals Anti-Arrhythmia Agents - pharmacology Antiarythmic agents Biological and medical sciences Cardiovascular system Chemical Phenomena Chemistry Ethanolamines - pharmacology Lidocaine - pharmacology Male Medical sciences Pharmacology. Drug treatments Rats Rats, Inbred Strains Verapamil - pharmacology |
| title | The antiarrhythmic activity of N-alkyl-1,2-diphenylethanolamines |
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