Alkaline phosphatase isoenzymes in rheumatic diseases
Serum alkaline phosphatase isoenzymes were determined quantitatively by electrophoresis on cellulose acetate in 168 patients with rheumatic diseases subgrouped for disease activity. Median values of total alkaline phosphatase and bone isoenzyme activity, as well as frequency of patients showing path...
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| Veröffentlicht in: | Clinical biochemistry 1989-04, Vol.22 (2), p.121-124 |
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| container_title | Clinical biochemistry |
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| creator | Siede, Werner H. Seiffert, Ulrich B. Merle, Steffen Goll, Hans-Günter Oremek, Gerhard |
| description | Serum alkaline phosphatase isoenzymes were determined quantitatively by electrophoresis on cellulose acetate in 168 patients with rheumatic diseases subgrouped for disease activity. Median values of total alkaline phosphatase and bone isoenzyme activity, as well as frequency of patients showing pathological values, increased gradually and significantly corresponding to disease activity in rheumatoid arthritis and ankylosing spondylitis, from 0% in inactive to 90% in very active forms. Bone isoenzyme was much more sensitive than total alkaline phosphatase in moderate disease activity and was also correlated to the number of involved extravertebral joints and pain in ankylosing spondylitis. No correlation was found with stage or duration of disease, age, sex, and erythrocyte sedimentation rate. Additional to bone isoenzyme, liver isoenzymes were elevated in some patients, but with only a weak correlation with disease activity. The intestinal isoenzymes were always normal. We conclude that quantitative determination of serum alkaline phosphatase bone isoenzyme activity is a major indicator for the assessment of disease activity and therapeutic monitoring in rheumatoid arthritis and ankylosing spondylitis. |
| doi_str_mv | 10.1016/S0009-9120(89)80009-8 |
| format | Article |
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Median values of total alkaline phosphatase and bone isoenzyme activity, as well as frequency of patients showing pathological values, increased gradually and significantly corresponding to disease activity in rheumatoid arthritis and ankylosing spondylitis, from 0% in inactive to 90% in very active forms. Bone isoenzyme was much more sensitive than total alkaline phosphatase in moderate disease activity and was also correlated to the number of involved extravertebral joints and pain in ankylosing spondylitis. No correlation was found with stage or duration of disease, age, sex, and erythrocyte sedimentation rate. Additional to bone isoenzyme, liver isoenzymes were elevated in some patients, but with only a weak correlation with disease activity. The intestinal isoenzymes were always normal. We conclude that quantitative determination of serum alkaline phosphatase bone isoenzyme activity is a major indicator for the assessment of disease activity and therapeutic monitoring in rheumatoid arthritis and ankylosing spondylitis.</description><identifier>ISSN: 0009-9120</identifier><identifier>EISSN: 1873-2933</identifier><identifier>DOI: 10.1016/S0009-9120(89)80009-8</identifier><identifier>PMID: 2720963</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>alkaline phosphatase ; Alkaline Phosphatase - blood ; Alkaline Phosphatase - metabolism ; ankylosing spondylitis ; Arthritis, Rheumatoid - enzymology ; Bone and Bones - enzymology ; Female ; Humans ; isoenzymes ; Isoenzymes - blood ; Isoenzymes - metabolism ; Liver - enzymology ; Lupus Erythematosus, Systemic - enzymology ; Male ; man ; Osteoarthritis - enzymology ; rheumatic diseases ; rheumatoid arthritis ; Spondylitis, Ankylosing - enzymology</subject><ispartof>Clinical biochemistry, 1989-04, Vol.22 (2), p.121-124</ispartof><rights>1989 The Canadian society of clinical chemists</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c391t-55e13ca9e56de884edc9e316b2b96aa2ba4cf4777cb865cdf3cf0b465a81b473</citedby><cites>FETCH-LOGICAL-c391t-55e13ca9e56de884edc9e316b2b96aa2ba4cf4777cb865cdf3cf0b465a81b473</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0009912089800098$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/2720963$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Siede, Werner H.</creatorcontrib><creatorcontrib>Seiffert, Ulrich B.</creatorcontrib><creatorcontrib>Merle, Steffen</creatorcontrib><creatorcontrib>Goll, Hans-Günter</creatorcontrib><creatorcontrib>Oremek, Gerhard</creatorcontrib><title>Alkaline phosphatase isoenzymes in rheumatic diseases</title><title>Clinical biochemistry</title><addtitle>Clin Biochem</addtitle><description>Serum alkaline phosphatase isoenzymes were determined quantitatively by electrophoresis on cellulose acetate in 168 patients with rheumatic diseases subgrouped for disease activity. Median values of total alkaline phosphatase and bone isoenzyme activity, as well as frequency of patients showing pathological values, increased gradually and significantly corresponding to disease activity in rheumatoid arthritis and ankylosing spondylitis, from 0% in inactive to 90% in very active forms. Bone isoenzyme was much more sensitive than total alkaline phosphatase in moderate disease activity and was also correlated to the number of involved extravertebral joints and pain in ankylosing spondylitis. No correlation was found with stage or duration of disease, age, sex, and erythrocyte sedimentation rate. Additional to bone isoenzyme, liver isoenzymes were elevated in some patients, but with only a weak correlation with disease activity. The intestinal isoenzymes were always normal. We conclude that quantitative determination of serum alkaline phosphatase bone isoenzyme activity is a major indicator for the assessment of disease activity and therapeutic monitoring in rheumatoid arthritis and ankylosing spondylitis.</description><subject>alkaline phosphatase</subject><subject>Alkaline Phosphatase - blood</subject><subject>Alkaline Phosphatase - metabolism</subject><subject>ankylosing spondylitis</subject><subject>Arthritis, Rheumatoid - enzymology</subject><subject>Bone and Bones - enzymology</subject><subject>Female</subject><subject>Humans</subject><subject>isoenzymes</subject><subject>Isoenzymes - blood</subject><subject>Isoenzymes - metabolism</subject><subject>Liver - enzymology</subject><subject>Lupus Erythematosus, Systemic - enzymology</subject><subject>Male</subject><subject>man</subject><subject>Osteoarthritis - enzymology</subject><subject>rheumatic diseases</subject><subject>rheumatoid arthritis</subject><subject>Spondylitis, Ankylosing - enzymology</subject><issn>0009-9120</issn><issn>1873-2933</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1989</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkEtLxDAUhYMoYx39CQNdiS6qeTRpspJh8AUDLpx9SNNbJtqXSSuMv97Og9nO6nI459wDH0Izgh8IJuLxE2OsEkUovpPqXu6UPEMRkRlLqGLsHEXHyCW6CuFrlDSVYoImNKNYCRYhPq--TeUaiLt1G7q16U2A2IUWmr9NDSF2TezXMNSmdzYuXIDRD9foojRVgJvDnaLVy_Nq8ZYsP17fF_NlYpkifcI5EGaNAi4KkDKFwipgROQ0V8IYmpvUlmmWZTaXgtuiZLbEeSq4kSRPMzZFt_u3nW9_Bgi9rl2wUFWmgXYIOpNKCkrZySDhjDJJyRjk-6D1bQgeSt15Vxu_0QTrLVa9w6q3zLRUeodVy7E3OwwMeQ3FsXXgOPpPex9GGr8OvA7WQWOhcB5sr4vWnVj4B0CXh3U</recordid><startdate>19890401</startdate><enddate>19890401</enddate><creator>Siede, Werner H.</creator><creator>Seiffert, Ulrich B.</creator><creator>Merle, Steffen</creator><creator>Goll, Hans-Günter</creator><creator>Oremek, Gerhard</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QL</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>M81</scope><scope>P64</scope><scope>7X8</scope></search><sort><creationdate>19890401</creationdate><title>Alkaline phosphatase isoenzymes in rheumatic diseases</title><author>Siede, Werner H. ; Seiffert, Ulrich B. ; Merle, Steffen ; Goll, Hans-Günter ; Oremek, Gerhard</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c391t-55e13ca9e56de884edc9e316b2b96aa2ba4cf4777cb865cdf3cf0b465a81b473</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1989</creationdate><topic>alkaline phosphatase</topic><topic>Alkaline Phosphatase - blood</topic><topic>Alkaline Phosphatase - metabolism</topic><topic>ankylosing spondylitis</topic><topic>Arthritis, Rheumatoid - enzymology</topic><topic>Bone and Bones - enzymology</topic><topic>Female</topic><topic>Humans</topic><topic>isoenzymes</topic><topic>Isoenzymes - blood</topic><topic>Isoenzymes - metabolism</topic><topic>Liver - enzymology</topic><topic>Lupus Erythematosus, Systemic - enzymology</topic><topic>Male</topic><topic>man</topic><topic>Osteoarthritis - enzymology</topic><topic>rheumatic diseases</topic><topic>rheumatoid arthritis</topic><topic>Spondylitis, Ankylosing - enzymology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Siede, Werner H.</creatorcontrib><creatorcontrib>Seiffert, Ulrich B.</creatorcontrib><creatorcontrib>Merle, Steffen</creatorcontrib><creatorcontrib>Goll, Hans-Günter</creatorcontrib><creatorcontrib>Oremek, Gerhard</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>Biochemistry Abstracts 3</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Clinical biochemistry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Siede, Werner H.</au><au>Seiffert, Ulrich B.</au><au>Merle, Steffen</au><au>Goll, Hans-Günter</au><au>Oremek, Gerhard</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Alkaline phosphatase isoenzymes in rheumatic diseases</atitle><jtitle>Clinical biochemistry</jtitle><addtitle>Clin Biochem</addtitle><date>1989-04-01</date><risdate>1989</risdate><volume>22</volume><issue>2</issue><spage>121</spage><epage>124</epage><pages>121-124</pages><issn>0009-9120</issn><eissn>1873-2933</eissn><abstract>Serum alkaline phosphatase isoenzymes were determined quantitatively by electrophoresis on cellulose acetate in 168 patients with rheumatic diseases subgrouped for disease activity. Median values of total alkaline phosphatase and bone isoenzyme activity, as well as frequency of patients showing pathological values, increased gradually and significantly corresponding to disease activity in rheumatoid arthritis and ankylosing spondylitis, from 0% in inactive to 90% in very active forms. Bone isoenzyme was much more sensitive than total alkaline phosphatase in moderate disease activity and was also correlated to the number of involved extravertebral joints and pain in ankylosing spondylitis. No correlation was found with stage or duration of disease, age, sex, and erythrocyte sedimentation rate. Additional to bone isoenzyme, liver isoenzymes were elevated in some patients, but with only a weak correlation with disease activity. The intestinal isoenzymes were always normal. We conclude that quantitative determination of serum alkaline phosphatase bone isoenzyme activity is a major indicator for the assessment of disease activity and therapeutic monitoring in rheumatoid arthritis and ankylosing spondylitis.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>2720963</pmid><doi>10.1016/S0009-9120(89)80009-8</doi><tpages>4</tpages></addata></record> |
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| subjects | alkaline phosphatase Alkaline Phosphatase - blood Alkaline Phosphatase - metabolism ankylosing spondylitis Arthritis, Rheumatoid - enzymology Bone and Bones - enzymology Female Humans isoenzymes Isoenzymes - blood Isoenzymes - metabolism Liver - enzymology Lupus Erythematosus, Systemic - enzymology Male man Osteoarthritis - enzymology rheumatic diseases rheumatoid arthritis Spondylitis, Ankylosing - enzymology |
| title | Alkaline phosphatase isoenzymes in rheumatic diseases |
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