Severe anterograde amnesia with onset in childhood as a result of anoxic encephalopathy
Our patient (M.S.) had an abrupt onset of amnesia due to a respiratory arrest at the age of 8 years and has been followed by one of us (A.L.R.) for 19 years. A specially designed MRI study indicated that the neuroanatomical localization of his lesion is restricted to the hippocampal formation bilate...
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| Veröffentlicht in: | Brain (London, England : 1878) England : 1878), 1997-03, Vol.120 (3), p.417-433 |
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| creator | BROMAN, M ROSE, A. L HOTSON, G CASEY, C. M |
| description | Our patient (M.S.) had an abrupt onset of amnesia due to a respiratory arrest at the age of 8 years and has been followed by one of us (A.L.R.) for 19 years. A specially designed MRI study indicated that the neuroanatomical localization of his lesion is restricted to the hippocampal formation bilaterally. Comparison of M.S.'s present IQ and academic scores with earlier scores revealed that his literacy skills, certain basic language functions and vocabulary development were arrested by his memory disorder. In contrast, development of mathematical skill was less curtailed, and verbal and nonverbal logical abilities developed to adult levels. Neuropsychological examination at the age of 27 years elicited a pattern of memory deficits similar to those found in a case (H.M.) of known mesial temporal lobe damage in adulthood. The neuropsychological pattern revealed those aspects of cognitive development that do, and those that do not, require intact memory. The limitations to intellectual development imposed by severe amnesia in childhood are not pervasive, but rather, are limited to specific types of abilities. |
| doi_str_mv | 10.1093/brain/120.3.417 |
| format | Article |
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The neuropsychological pattern revealed those aspects of cognitive development that do, and those that do not, require intact memory. The limitations to intellectual development imposed by severe amnesia in childhood are not pervasive, but rather, are limited to specific types of abilities.</description><identifier>ISSN: 0006-8950</identifier><identifier>ISSN: 1460-2156</identifier><identifier>EISSN: 1460-2156</identifier><identifier>DOI: 10.1093/brain/120.3.417</identifier><identifier>PMID: 9126054</identifier><identifier>CODEN: BRAIAK</identifier><language>eng</language><publisher>Oxford: Oxford University Press</publisher><subject>Adult ; Amnesia - etiology ; Anomia - etiology ; Biological and medical sciences ; Brain Damage, Chronic - complications ; Brain Damage, Chronic - diagnosis ; Child ; Disorders of higher nervous function. Focal brain diseases. Central vestibular syndrome and deafness. Brain stem syndromes ; Humans ; Hypoxia, Brain - complications ; Hypoxia, Brain - diagnosis ; Intelligence ; Language Disorders - etiology ; Male ; Medical sciences ; Nervous system (semeiology, syndromes) ; Neurology ; Neuropsychological Tests ; Perception ; Temporal Lobe - pathology ; Verbal Learning</subject><ispartof>Brain (London, England : 1878), 1997-03, Vol.120 (3), p.417-433</ispartof><rights>1997 INIST-CNRS</rights><rights>Copyright Oxford University Press Mar 1997</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c449t-9bbd7b8aa49a22e9cc420cf4e806b63ec1eee1af702772cd5d26309de939ae613</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>315,782,786,27931,27932</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=2629168$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/9126054$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>BROMAN, M</creatorcontrib><creatorcontrib>ROSE, A. L</creatorcontrib><creatorcontrib>HOTSON, G</creatorcontrib><creatorcontrib>CASEY, C. M</creatorcontrib><title>Severe anterograde amnesia with onset in childhood as a result of anoxic encephalopathy</title><title>Brain (London, England : 1878)</title><addtitle>Brain</addtitle><description>Our patient (M.S.) had an abrupt onset of amnesia due to a respiratory arrest at the age of 8 years and has been followed by one of us (A.L.R.) for 19 years. A specially designed MRI study indicated that the neuroanatomical localization of his lesion is restricted to the hippocampal formation bilaterally. Comparison of M.S.'s present IQ and academic scores with earlier scores revealed that his literacy skills, certain basic language functions and vocabulary development were arrested by his memory disorder. In contrast, development of mathematical skill was less curtailed, and verbal and nonverbal logical abilities developed to adult levels. Neuropsychological examination at the age of 27 years elicited a pattern of memory deficits similar to those found in a case (H.M.) of known mesial temporal lobe damage in adulthood. The neuropsychological pattern revealed those aspects of cognitive development that do, and those that do not, require intact memory. The limitations to intellectual development imposed by severe amnesia in childhood are not pervasive, but rather, are limited to specific types of abilities.</description><subject>Adult</subject><subject>Amnesia - etiology</subject><subject>Anomia - etiology</subject><subject>Biological and medical sciences</subject><subject>Brain Damage, Chronic - complications</subject><subject>Brain Damage, Chronic - diagnosis</subject><subject>Child</subject><subject>Disorders of higher nervous function. Focal brain diseases. Central vestibular syndrome and deafness. Brain stem syndromes</subject><subject>Humans</subject><subject>Hypoxia, Brain - complications</subject><subject>Hypoxia, Brain - diagnosis</subject><subject>Intelligence</subject><subject>Language Disorders - etiology</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Nervous system (semeiology, syndromes)</subject><subject>Neurology</subject><subject>Neuropsychological Tests</subject><subject>Perception</subject><subject>Temporal Lobe - pathology</subject><subject>Verbal Learning</subject><issn>0006-8950</issn><issn>1460-2156</issn><issn>1460-2156</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1997</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkU1r3DAQhkVpSDdpzz0VRCm5eVdflqxjCf2CQA5N6FGM5XGt4JW2kp02_75qs-TQS08zMM_7wvAQ8pqzLWdW7voMIe64YFu5Vdw8IxuuNGsEb_VzsmGM6aazLXtBzkq5Y4wrKfQpObVcaNaqDfn2Fe8xI4W4YE7fMwx130csAejPsEw0xYILDZH6KczDlNJAoVCgGcs6LzSNNZp-BU8xejxMMKcDLNPDS3Iywlzw1XGek9uPH24uPzdX15--XL6_arxSdmls3w-m7wCUBSHQeq8E86PCjuleS_QcETmMhgljhB_aQWjJ7IBWWkDN5Tm5eOw95PRjxbK4fSge5xkiprU409muNZ36LyiY5lwxXcG3_4B3ac2xPuG4bZXkRpkK7R4hn1MpGUd3yGEP-cFx5v6IcX_FuCrGSVfF1MSbY-3a73F44o8m6v3d8Q7FwzxmiD6UJ0xoYbnu5G-LJpcB</recordid><startdate>19970301</startdate><enddate>19970301</enddate><creator>BROMAN, M</creator><creator>ROSE, A. 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M</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c449t-9bbd7b8aa49a22e9cc420cf4e806b63ec1eee1af702772cd5d26309de939ae613</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1997</creationdate><topic>Adult</topic><topic>Amnesia - etiology</topic><topic>Anomia - etiology</topic><topic>Biological and medical sciences</topic><topic>Brain Damage, Chronic - complications</topic><topic>Brain Damage, Chronic - diagnosis</topic><topic>Child</topic><topic>Disorders of higher nervous function. Focal brain diseases. Central vestibular syndrome and deafness. 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Comparison of M.S.'s present IQ and academic scores with earlier scores revealed that his literacy skills, certain basic language functions and vocabulary development were arrested by his memory disorder. In contrast, development of mathematical skill was less curtailed, and verbal and nonverbal logical abilities developed to adult levels. Neuropsychological examination at the age of 27 years elicited a pattern of memory deficits similar to those found in a case (H.M.) of known mesial temporal lobe damage in adulthood. The neuropsychological pattern revealed those aspects of cognitive development that do, and those that do not, require intact memory. The limitations to intellectual development imposed by severe amnesia in childhood are not pervasive, but rather, are limited to specific types of abilities.</abstract><cop>Oxford</cop><pub>Oxford University Press</pub><pmid>9126054</pmid><doi>10.1093/brain/120.3.417</doi><tpages>17</tpages><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; Oxford University Press Journals All Titles (1996-Current); EZB-FREE-00999 freely available EZB journals |
| subjects | Adult Amnesia - etiology Anomia - etiology Biological and medical sciences Brain Damage, Chronic - complications Brain Damage, Chronic - diagnosis Child Disorders of higher nervous function. Focal brain diseases. Central vestibular syndrome and deafness. Brain stem syndromes Humans Hypoxia, Brain - complications Hypoxia, Brain - diagnosis Intelligence Language Disorders - etiology Male Medical sciences Nervous system (semeiology, syndromes) Neurology Neuropsychological Tests Perception Temporal Lobe - pathology Verbal Learning |
| title | Severe anterograde amnesia with onset in childhood as a result of anoxic encephalopathy |
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