Inhibition of the growth of pre‐established subcutaneous tumor nodules of human prostate cancer cells by single injection of the recombinant adenovirus p53 expression vector
We have previously described potent growth‐inhibitory effect of a recombinant adenovirus expressing wild type p53 (AdWTp53) in metastatic prostate cancer cells via activation of cellular p53 pathways. We have extended these observations to analyze the effects of AdWTp53 on primary cultures of radica...
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| Veröffentlicht in: | International journal of cancer 1997-05, Vol.71 (3), p.377-382 |
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| container_title | International journal of cancer |
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| creator | Asgari, Kekule Sesterhenn, Isabell A. McLeod, David G. Cowan, Kenneth Moul, Judd W. Seth, Prem Srivastava, Shiv |
| description | We have previously described potent growth‐inhibitory effect of a recombinant adenovirus expressing wild type p53 (AdWTp53) in metastatic prostate cancer cells via activation of cellular p53 pathways. We have extended these observations to analyze the effects of AdWTp53 on primary cultures of radical prostatectomy specimens (RPS) and have also evaluated the gene therapeutic potential of the AdWTp53 in a nude mice model. Infection of primary cultures of prostate cancer specimens resulted in about 80% cell growth inhibition in comparison with cultures treated with control adenovirus dl312. Single injection of AdWTp53 into pre‐established tumor nodules of DU145 prostate cancer cells suppressed tumor growth significantly (p = 0.0407) as determined by comparison of tumor volumes of the AdWTp53‐treated vs. control vector (dl312) or PBS‐treated groups. Moreover, there was no significant difference in tumor growth inhibition between single vs. multiple injections of AdWTp53. Our observations support the potential of AdWTp53 for gene therapy of prostate cancer. Int. J. Cancer 71:377‐382, 1997. © 1997 Wiley‐Liss Inc. |
| doi_str_mv | 10.1002/(SICI)1097-0215(19970502)71:3<377::AID-IJC13>3.0.CO;2-D |
| format | Article |
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We have extended these observations to analyze the effects of AdWTp53 on primary cultures of radical prostatectomy specimens (RPS) and have also evaluated the gene therapeutic potential of the AdWTp53 in a nude mice model. Infection of primary cultures of prostate cancer specimens resulted in about 80% cell growth inhibition in comparison with cultures treated with control adenovirus dl312. Single injection of AdWTp53 into pre‐established tumor nodules of DU145 prostate cancer cells suppressed tumor growth significantly (p = 0.0407) as determined by comparison of tumor volumes of the AdWTp53‐treated vs. control vector (dl312) or PBS‐treated groups. Moreover, there was no significant difference in tumor growth inhibition between single vs. multiple injections of AdWTp53. Our observations support the potential of AdWTp53 for gene therapy of prostate cancer. Int. J. Cancer 71:377‐382, 1997. © 1997 Wiley‐Liss Inc.</description><identifier>ISSN: 0020-7136</identifier><identifier>EISSN: 1097-0215</identifier><identifier>DOI: 10.1002/(SICI)1097-0215(19970502)71:3<377::AID-IJC13>3.0.CO;2-D</identifier><identifier>PMID: 9139872</identifier><identifier>CODEN: IJCNAW</identifier><language>eng</language><publisher>New York: Wiley Subscription Services, Inc., A Wiley Company</publisher><subject>Adenoviridae ; adenovirus ; Animal tumors. Experimental tumors ; Animals ; Biological and medical sciences ; Cell Division ; Experimental renal and urinary tract tumors ; Genes, p53 ; Genetic Therapy - methods ; Genetic Vectors ; Humans ; Male ; Medical sciences ; Mice ; Mice, Nude ; Neoplasm Staging ; Other treatments ; Prostatectomy ; Prostatic Neoplasms - pathology ; Prostatic Neoplasms - surgery ; Prostatic Neoplasms - therapy ; Recombinant Proteins - biosynthesis ; Time Factors ; Transfection - methods ; Transplantation, Heterologous ; Treatment. 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We have extended these observations to analyze the effects of AdWTp53 on primary cultures of radical prostatectomy specimens (RPS) and have also evaluated the gene therapeutic potential of the AdWTp53 in a nude mice model. Infection of primary cultures of prostate cancer specimens resulted in about 80% cell growth inhibition in comparison with cultures treated with control adenovirus dl312. Single injection of AdWTp53 into pre‐established tumor nodules of DU145 prostate cancer cells suppressed tumor growth significantly (p = 0.0407) as determined by comparison of tumor volumes of the AdWTp53‐treated vs. control vector (dl312) or PBS‐treated groups. Moreover, there was no significant difference in tumor growth inhibition between single vs. multiple injections of AdWTp53. Our observations support the potential of AdWTp53 for gene therapy of prostate cancer. Int. J. Cancer 71:377‐382, 1997. © 1997 Wiley‐Liss Inc.</description><subject>Adenoviridae</subject><subject>adenovirus</subject><subject>Animal tumors. Experimental tumors</subject><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Cell Division</subject><subject>Experimental renal and urinary tract tumors</subject><subject>Genes, p53</subject><subject>Genetic Therapy - methods</subject><subject>Genetic Vectors</subject><subject>Humans</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Mice</subject><subject>Mice, Nude</subject><subject>Neoplasm Staging</subject><subject>Other treatments</subject><subject>Prostatectomy</subject><subject>Prostatic Neoplasms - pathology</subject><subject>Prostatic Neoplasms - surgery</subject><subject>Prostatic Neoplasms - therapy</subject><subject>Recombinant Proteins - biosynthesis</subject><subject>Time Factors</subject><subject>Transfection - methods</subject><subject>Transplantation, Heterologous</subject><subject>Treatment. General aspects</subject><subject>Tumor Cells, Cultured</subject><subject>Tumor Suppressor Protein p53 - biosynthesis</subject><subject>Tumors</subject><issn>0020-7136</issn><issn>1097-0215</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1997</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkc1u1DAUhSMEKkPhEZC8QKhdZPBPEidTBKoy_ARVmgUg2FmOc9O4SpzBTlpmxyPwJrwTT4JDhhESSF1Zts8999z7BcFLgpcEY_rs5H2RF6cEZzzElMQnJMs4jjE95WTFnjPOV6vzYh0W73LCXrAlXuabMxqu7wSLQ83dYOGdcMgJS-4HD5y7wpiQGEdHwVFGWJZyugh-FKbRpR50b1Bfo6EBdGn7m6GZblsLP799BzfIstWugQq5sVTjIA30o0PD2PUWmb4aW3CTvhk7aXxV7ysGQEoaBRYpaFuHyh1y2ly2gLS5AvV3Qwuq70ptpBmQrMD019p6-23MEHz1GZybxNe-qLcPg3u1bB082p_HwcfXrz7kb8OLzZsiP78IFYsoCxOZqQxYjBNSKkxAlgzSJKorSnFdValUcVRFGedVDawuUyajWEka-Rujym_sOHg6-_ppvox-BaLTbppknl3wNEvjiGa3CklCMEkY98JPs1D5_TgLtdha3Um7EwSLibkQE3Mx8RMTP_GHueBEMOGZC-GZi9_M_QMW-UZQsfbOj_cRxrKD6uC7h-z_n-z_pVOyra3not1BRhPfA08BP8-yG93C7p90t4b7X7b5gf0CfzvZwQ</recordid><startdate>19970502</startdate><enddate>19970502</enddate><creator>Asgari, Kekule</creator><creator>Sesterhenn, Isabell A.</creator><creator>McLeod, David G.</creator><creator>Cowan, Kenneth</creator><creator>Moul, Judd W.</creator><creator>Seth, Prem</creator><creator>Srivastava, Shiv</creator><general>Wiley Subscription Services, Inc., A Wiley Company</general><general>Wiley-Liss</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TO</scope><scope>H94</scope><scope>7X8</scope></search><sort><creationdate>19970502</creationdate><title>Inhibition of the growth of pre‐established subcutaneous tumor nodules of human prostate cancer cells by single injection of the recombinant adenovirus p53 expression vector</title><author>Asgari, Kekule ; Sesterhenn, Isabell A. ; McLeod, David G. ; Cowan, Kenneth ; Moul, Judd W. ; Seth, Prem ; Srivastava, Shiv</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3423-6a9c9e35061bc01eab3e864fd220fdd8ac54d4977dfe3fb83a45ca24fe332c713</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1997</creationdate><topic>Adenoviridae</topic><topic>adenovirus</topic><topic>Animal tumors. Experimental tumors</topic><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Cell Division</topic><topic>Experimental renal and urinary tract tumors</topic><topic>Genes, p53</topic><topic>Genetic Therapy - methods</topic><topic>Genetic Vectors</topic><topic>Humans</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Mice</topic><topic>Mice, Nude</topic><topic>Neoplasm Staging</topic><topic>Other treatments</topic><topic>Prostatectomy</topic><topic>Prostatic Neoplasms - pathology</topic><topic>Prostatic Neoplasms - surgery</topic><topic>Prostatic Neoplasms - therapy</topic><topic>Recombinant Proteins - biosynthesis</topic><topic>Time Factors</topic><topic>Transfection - methods</topic><topic>Transplantation, Heterologous</topic><topic>Treatment. General aspects</topic><topic>Tumor Cells, Cultured</topic><topic>Tumor Suppressor Protein p53 - biosynthesis</topic><topic>Tumors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Asgari, Kekule</creatorcontrib><creatorcontrib>Sesterhenn, Isabell A.</creatorcontrib><creatorcontrib>McLeod, David G.</creatorcontrib><creatorcontrib>Cowan, Kenneth</creatorcontrib><creatorcontrib>Moul, Judd W.</creatorcontrib><creatorcontrib>Seth, Prem</creatorcontrib><creatorcontrib>Srivastava, Shiv</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>International journal of cancer</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Asgari, Kekule</au><au>Sesterhenn, Isabell A.</au><au>McLeod, David G.</au><au>Cowan, Kenneth</au><au>Moul, Judd W.</au><au>Seth, Prem</au><au>Srivastava, Shiv</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Inhibition of the growth of pre‐established subcutaneous tumor nodules of human prostate cancer cells by single injection of the recombinant adenovirus p53 expression vector</atitle><jtitle>International journal of cancer</jtitle><addtitle>Int J Cancer</addtitle><date>1997-05-02</date><risdate>1997</risdate><volume>71</volume><issue>3</issue><spage>377</spage><epage>382</epage><pages>377-382</pages><issn>0020-7136</issn><eissn>1097-0215</eissn><coden>IJCNAW</coden><abstract>We have previously described potent growth‐inhibitory effect of a recombinant adenovirus expressing wild type p53 (AdWTp53) in metastatic prostate cancer cells via activation of cellular p53 pathways. We have extended these observations to analyze the effects of AdWTp53 on primary cultures of radical prostatectomy specimens (RPS) and have also evaluated the gene therapeutic potential of the AdWTp53 in a nude mice model. Infection of primary cultures of prostate cancer specimens resulted in about 80% cell growth inhibition in comparison with cultures treated with control adenovirus dl312. Single injection of AdWTp53 into pre‐established tumor nodules of DU145 prostate cancer cells suppressed tumor growth significantly (p = 0.0407) as determined by comparison of tumor volumes of the AdWTp53‐treated vs. control vector (dl312) or PBS‐treated groups. Moreover, there was no significant difference in tumor growth inhibition between single vs. multiple injections of AdWTp53. Our observations support the potential of AdWTp53 for gene therapy of prostate cancer. Int. J. Cancer 71:377‐382, 1997. © 1997 Wiley‐Liss Inc.</abstract><cop>New York</cop><pub>Wiley Subscription Services, Inc., A Wiley Company</pub><pmid>9139872</pmid><doi>10.1002/(SICI)1097-0215(19970502)71:3<377::AID-IJC13>3.0.CO;2-D</doi><tpages>6</tpages></addata></record> |
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| ispartof | International journal of cancer, 1997-05, Vol.71 (3), p.377-382 |
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| source | MEDLINE; Wiley Online Library Journals Frontfile Complete; EZB-FREE-00999 freely available EZB journals |
| subjects | Adenoviridae adenovirus Animal tumors. Experimental tumors Animals Biological and medical sciences Cell Division Experimental renal and urinary tract tumors Genes, p53 Genetic Therapy - methods Genetic Vectors Humans Male Medical sciences Mice Mice, Nude Neoplasm Staging Other treatments Prostatectomy Prostatic Neoplasms - pathology Prostatic Neoplasms - surgery Prostatic Neoplasms - therapy Recombinant Proteins - biosynthesis Time Factors Transfection - methods Transplantation, Heterologous Treatment. General aspects Tumor Cells, Cultured Tumor Suppressor Protein p53 - biosynthesis Tumors |
| title | Inhibition of the growth of pre‐established subcutaneous tumor nodules of human prostate cancer cells by single injection of the recombinant adenovirus p53 expression vector |
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