Effect of exercise training on myocardial remodeling in patients with reduced left ventricular function after myocardial infarction : Application of magnetic resonance imaging
There are conflicting reports on the effects of training on the remodeling process in post-myocardial infarction patients with ventricular damage. Twenty-five patients with reduced ventricular function (mean ejection fraction, 32.3+/-6%) after an anteroseptal or inferolateral myocardial infarction w...
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| Veröffentlicht in: | Circulation (New York, N.Y.) N.Y.), 1997-04, Vol.95 (8), p.2060-2067 |
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| container_title | Circulation (New York, N.Y.) |
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| creator | DUBACH, P MYERS, J DZIEKAN, G GOEBBELS, U REINHART, W VOGT, P RATTI, R MULLER, P MIETTUNEN, R BUSER, P |
| description | There are conflicting reports on the effects of training on the remodeling process in post-myocardial infarction patients with ventricular damage.
Twenty-five patients with reduced ventricular function (mean ejection fraction, 32.3+/-6%) after an anteroseptal or inferolateral myocardial infarction were randomized to an exercise group (n=12) or a control group (n=13). Patients in the exercise group resided in a rehabilitation center for 2 months and underwent a training program consisting of two 1-hour sessions of walking daily, along with four monitored 45-minute sessions of stationary cycling weekly. Before and after the study period, maximal exercise testing and cardiac MRI were performed. Oxygen uptake increased 26% at maximal exercise (19.7+/-3 to 23.9+/-5, P |
| doi_str_mv | 10.1161/01.CIR.95.8.2060 |
| format | Article |
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Twenty-five patients with reduced ventricular function (mean ejection fraction, 32.3+/-6%) after an anteroseptal or inferolateral myocardial infarction were randomized to an exercise group (n=12) or a control group (n=13). Patients in the exercise group resided in a rehabilitation center for 2 months and underwent a training program consisting of two 1-hour sessions of walking daily, along with four monitored 45-minute sessions of stationary cycling weekly. Before and after the study period, maximal exercise testing and cardiac MRI were performed. Oxygen uptake increased 26% at maximal exercise (19.7+/-3 to 23.9+/-5, P<.05) and 39% at the lactate threshold (P<.01) in the exercise group, whereas control values did not change. No differences were observed within or between groups in MRI measures of end-diastolic (187+/-47 pre versus 196+/-35 mL post in the exercise group and 179+/-52 pre versus 180+/-51 mL post in the control group), end-systolic volume (118+/-41 pre versus 121+/-33 mL post in the exercise group and 119+/-54 pre versus 116+/-56 mL post in the control group), or ejection fraction (38.0+/-9 pre versus 38.2+/-10% post in the exercise group and 37.0+/-10 pre versus 38.3+/-13% post in the control group). Myocardial wall thickness measurements at end diastole and end systole and their difference in 80 myocardial segments determined by MRI yielded no significant interactions between groups. When myocardial wall thickness measurements were classified by infarct or noninfarct areas, no differences were observed between groups over the study period.
A high-intensity, 2-month residential cardiac rehabilitation program resulted in substantial increases in exercise capacity among patients with reduced left ventricular function. In contrast to some recent reports, the training program had no deleterious effects on left ventricular volume, function, or wall thickness regardless of infarct area.</description><identifier>ISSN: 0009-7322</identifier><identifier>EISSN: 1524-4539</identifier><identifier>DOI: 10.1161/01.CIR.95.8.2060</identifier><identifier>PMID: 9133516</identifier><identifier>CODEN: CIRCAZ</identifier><language>eng</language><publisher>Hagerstown, MD: Lippincott Williams & Wilkins</publisher><subject>Biological and medical sciences ; Cardiology. Vascular system ; Coronary heart disease ; Exercise Test ; Exercise Therapy ; Heart ; Heart Failure - etiology ; Heart Failure - pathology ; Heart Failure - therapy ; Hemodynamics ; Humans ; Magnetic Resonance Imaging ; Male ; Medical sciences ; Middle Aged ; Myocardial Infarction - complications ; Myocardial Infarction - pathology ; Myocardial Infarction - physiopathology ; Myocardial Infarction - rehabilitation ; Myocardium - pathology ; Treatment Outcome ; Ventricular Function, Left</subject><ispartof>Circulation (New York, N.Y.), 1997-04, Vol.95 (8), p.2060-2067</ispartof><rights>1997 INIST-CNRS</rights><rights>Copyright American Heart Association, Inc. Apr 15, 1997</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c344t-5ea5e1f8152d4e026c18308051f5c41bb5b169a9dc01a5a98f647f53ef8ce2d53</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,777,781,3674,27905,27906</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=2638249$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/9133516$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>DUBACH, P</creatorcontrib><creatorcontrib>MYERS, J</creatorcontrib><creatorcontrib>DZIEKAN, G</creatorcontrib><creatorcontrib>GOEBBELS, U</creatorcontrib><creatorcontrib>REINHART, W</creatorcontrib><creatorcontrib>VOGT, P</creatorcontrib><creatorcontrib>RATTI, R</creatorcontrib><creatorcontrib>MULLER, P</creatorcontrib><creatorcontrib>MIETTUNEN, R</creatorcontrib><creatorcontrib>BUSER, P</creatorcontrib><title>Effect of exercise training on myocardial remodeling in patients with reduced left ventricular function after myocardial infarction : Application of magnetic resonance imaging</title><title>Circulation (New York, N.Y.)</title><addtitle>Circulation</addtitle><description>There are conflicting reports on the effects of training on the remodeling process in post-myocardial infarction patients with ventricular damage.
Twenty-five patients with reduced ventricular function (mean ejection fraction, 32.3+/-6%) after an anteroseptal or inferolateral myocardial infarction were randomized to an exercise group (n=12) or a control group (n=13). Patients in the exercise group resided in a rehabilitation center for 2 months and underwent a training program consisting of two 1-hour sessions of walking daily, along with four monitored 45-minute sessions of stationary cycling weekly. Before and after the study period, maximal exercise testing and cardiac MRI were performed. Oxygen uptake increased 26% at maximal exercise (19.7+/-3 to 23.9+/-5, P<.05) and 39% at the lactate threshold (P<.01) in the exercise group, whereas control values did not change. No differences were observed within or between groups in MRI measures of end-diastolic (187+/-47 pre versus 196+/-35 mL post in the exercise group and 179+/-52 pre versus 180+/-51 mL post in the control group), end-systolic volume (118+/-41 pre versus 121+/-33 mL post in the exercise group and 119+/-54 pre versus 116+/-56 mL post in the control group), or ejection fraction (38.0+/-9 pre versus 38.2+/-10% post in the exercise group and 37.0+/-10 pre versus 38.3+/-13% post in the control group). Myocardial wall thickness measurements at end diastole and end systole and their difference in 80 myocardial segments determined by MRI yielded no significant interactions between groups. When myocardial wall thickness measurements were classified by infarct or noninfarct areas, no differences were observed between groups over the study period.
A high-intensity, 2-month residential cardiac rehabilitation program resulted in substantial increases in exercise capacity among patients with reduced left ventricular function. In contrast to some recent reports, the training program had no deleterious effects on left ventricular volume, function, or wall thickness regardless of infarct area.</description><subject>Biological and medical sciences</subject><subject>Cardiology. Vascular system</subject><subject>Coronary heart disease</subject><subject>Exercise Test</subject><subject>Exercise Therapy</subject><subject>Heart</subject><subject>Heart Failure - etiology</subject><subject>Heart Failure - pathology</subject><subject>Heart Failure - therapy</subject><subject>Hemodynamics</subject><subject>Humans</subject><subject>Magnetic Resonance Imaging</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Myocardial Infarction - complications</subject><subject>Myocardial Infarction - pathology</subject><subject>Myocardial Infarction - physiopathology</subject><subject>Myocardial Infarction - rehabilitation</subject><subject>Myocardium - pathology</subject><subject>Treatment Outcome</subject><subject>Ventricular Function, Left</subject><issn>0009-7322</issn><issn>1524-4539</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1997</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpdUU1rFTEUDWKpz-rejRBE3M2Yz5nEXXlULRQKouuQl7mpKTOZMclU-6v8i83zPYp0dbn3nHvux0HoDSUtpR39SGi7vfzWatmqlpGOPEMbKplohOT6OdoQQnTTc8ZeoJc539a04708Raeaci5pt0F_L7wHV_DsMfyB5EIGXJINMcQbPEc83c_OpiHYESeY5gHGPRAiXmwJEEvGv0P5WbFhdTDgEXzBd7WegltHm7BfoyuhCllfIP0vF6K36YB9wufLMgZn_2V1lcneRCjBVd08Rxsd4FBrdfQrdOLtmOH1MZ6hH58vvm-_NlfXXy6351eN40KURoKVQL2qzxgEENY5qjhRRFIvnaC7ndzRTls9OEKttFr5TvRecvDKARskP0MfDrpLmn-tkIuZQnYwjjbCvGbTK60kFXviuyfE23lNse5mGGU9F1SRSiIHkktzzgm8WVI9KN0bSszeSEOoqUYaLY0yeyNry9uj7rqbYHhsODpX8fdH3GZnR5_ql0J-pLGOKyY0fwCA3aml</recordid><startdate>19970415</startdate><enddate>19970415</enddate><creator>DUBACH, P</creator><creator>MYERS, J</creator><creator>DZIEKAN, G</creator><creator>GOEBBELS, U</creator><creator>REINHART, W</creator><creator>VOGT, P</creator><creator>RATTI, R</creator><creator>MULLER, P</creator><creator>MIETTUNEN, R</creator><creator>BUSER, P</creator><general>Lippincott Williams & Wilkins</general><general>American Heart Association, Inc</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>U9A</scope><scope>7X8</scope></search><sort><creationdate>19970415</creationdate><title>Effect of exercise training on myocardial remodeling in patients with reduced left ventricular function after myocardial infarction : Application of magnetic resonance imaging</title><author>DUBACH, P ; MYERS, J ; DZIEKAN, G ; GOEBBELS, U ; REINHART, W ; VOGT, P ; RATTI, R ; MULLER, P ; MIETTUNEN, R ; BUSER, P</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c344t-5ea5e1f8152d4e026c18308051f5c41bb5b169a9dc01a5a98f647f53ef8ce2d53</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1997</creationdate><topic>Biological and medical sciences</topic><topic>Cardiology. Vascular system</topic><topic>Coronary heart disease</topic><topic>Exercise Test</topic><topic>Exercise Therapy</topic><topic>Heart</topic><topic>Heart Failure - etiology</topic><topic>Heart Failure - pathology</topic><topic>Heart Failure - therapy</topic><topic>Hemodynamics</topic><topic>Humans</topic><topic>Magnetic Resonance Imaging</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Myocardial Infarction - complications</topic><topic>Myocardial Infarction - pathology</topic><topic>Myocardial Infarction - physiopathology</topic><topic>Myocardial Infarction - rehabilitation</topic><topic>Myocardium - pathology</topic><topic>Treatment Outcome</topic><topic>Ventricular Function, Left</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>DUBACH, P</creatorcontrib><creatorcontrib>MYERS, J</creatorcontrib><creatorcontrib>DZIEKAN, G</creatorcontrib><creatorcontrib>GOEBBELS, U</creatorcontrib><creatorcontrib>REINHART, W</creatorcontrib><creatorcontrib>VOGT, P</creatorcontrib><creatorcontrib>RATTI, R</creatorcontrib><creatorcontrib>MULLER, P</creatorcontrib><creatorcontrib>MIETTUNEN, R</creatorcontrib><creatorcontrib>BUSER, P</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><collection>MEDLINE - Academic</collection><jtitle>Circulation (New York, N.Y.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>DUBACH, P</au><au>MYERS, J</au><au>DZIEKAN, G</au><au>GOEBBELS, U</au><au>REINHART, W</au><au>VOGT, P</au><au>RATTI, R</au><au>MULLER, P</au><au>MIETTUNEN, R</au><au>BUSER, P</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effect of exercise training on myocardial remodeling in patients with reduced left ventricular function after myocardial infarction : Application of magnetic resonance imaging</atitle><jtitle>Circulation (New York, N.Y.)</jtitle><addtitle>Circulation</addtitle><date>1997-04-15</date><risdate>1997</risdate><volume>95</volume><issue>8</issue><spage>2060</spage><epage>2067</epage><pages>2060-2067</pages><issn>0009-7322</issn><eissn>1524-4539</eissn><coden>CIRCAZ</coden><abstract>There are conflicting reports on the effects of training on the remodeling process in post-myocardial infarction patients with ventricular damage.
Twenty-five patients with reduced ventricular function (mean ejection fraction, 32.3+/-6%) after an anteroseptal or inferolateral myocardial infarction were randomized to an exercise group (n=12) or a control group (n=13). Patients in the exercise group resided in a rehabilitation center for 2 months and underwent a training program consisting of two 1-hour sessions of walking daily, along with four monitored 45-minute sessions of stationary cycling weekly. Before and after the study period, maximal exercise testing and cardiac MRI were performed. Oxygen uptake increased 26% at maximal exercise (19.7+/-3 to 23.9+/-5, P<.05) and 39% at the lactate threshold (P<.01) in the exercise group, whereas control values did not change. No differences were observed within or between groups in MRI measures of end-diastolic (187+/-47 pre versus 196+/-35 mL post in the exercise group and 179+/-52 pre versus 180+/-51 mL post in the control group), end-systolic volume (118+/-41 pre versus 121+/-33 mL post in the exercise group and 119+/-54 pre versus 116+/-56 mL post in the control group), or ejection fraction (38.0+/-9 pre versus 38.2+/-10% post in the exercise group and 37.0+/-10 pre versus 38.3+/-13% post in the control group). Myocardial wall thickness measurements at end diastole and end systole and their difference in 80 myocardial segments determined by MRI yielded no significant interactions between groups. When myocardial wall thickness measurements were classified by infarct or noninfarct areas, no differences were observed between groups over the study period.
A high-intensity, 2-month residential cardiac rehabilitation program resulted in substantial increases in exercise capacity among patients with reduced left ventricular function. In contrast to some recent reports, the training program had no deleterious effects on left ventricular volume, function, or wall thickness regardless of infarct area.</abstract><cop>Hagerstown, MD</cop><pub>Lippincott Williams & Wilkins</pub><pmid>9133516</pmid><doi>10.1161/01.CIR.95.8.2060</doi><tpages>8</tpages></addata></record> |
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| identifier | ISSN: 0009-7322 |
| ispartof | Circulation (New York, N.Y.), 1997-04, Vol.95 (8), p.2060-2067 |
| issn | 0009-7322 1524-4539 |
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| source | MEDLINE; American Heart Association Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Journals@Ovid Complete |
| subjects | Biological and medical sciences Cardiology. Vascular system Coronary heart disease Exercise Test Exercise Therapy Heart Heart Failure - etiology Heart Failure - pathology Heart Failure - therapy Hemodynamics Humans Magnetic Resonance Imaging Male Medical sciences Middle Aged Myocardial Infarction - complications Myocardial Infarction - pathology Myocardial Infarction - physiopathology Myocardial Infarction - rehabilitation Myocardium - pathology Treatment Outcome Ventricular Function, Left |
| title | Effect of exercise training on myocardial remodeling in patients with reduced left ventricular function after myocardial infarction : Application of magnetic resonance imaging |
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