Alveolar Damage in AIDS-Related Pneumocystis carinii Pneumonia
Pneumocystis carinii pneumonia is the most common and serious of the pulmonary complications of AIDS. Despite this, many basic aspects in the pathogenesis of HIV-associated P carinii pneumonia are unknown. We therefore undertook a light and electron microscopic study of transbronchial biopsy specime...
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| Veröffentlicht in: | Chest 1997-05, Vol.111 (5), p.1193-1199 |
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| creator | Benfield, Thomas L. Prentø, Poul Junge, Jette Vestbo, Jørgen Lundgren, Jens D. |
| description | Pneumocystis carinii pneumonia is the most common and serious of the pulmonary complications of AIDS. Despite this, many basic aspects in the pathogenesis of HIV-associated P carinii pneumonia are unknown. We therefore undertook a light and electron microscopic study of transbronchial biopsy specimens to compare pathologic features of P carinii pneumonia and other HIV-related lung diseases.
Thirty-seven consecutive HIV-infected patients undergoing a diagnostic bronchoscopy.
P carinii pneumonia was characterized by an increase in inflammation, edema, exudate, fibrosis, type II pneumocyte proliferation, and cellular infiltration of the alveolar wall when compared with other lung diseases (all p |
| doi_str_mv | 10.1378/chest.111.5.1193 |
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Thirty-seven consecutive HIV-infected patients undergoing a diagnostic bronchoscopy.
P carinii pneumonia was characterized by an increase in inflammation, edema, exudate, fibrosis, type II pneumocyte proliferation, and cellular infiltration of the alveolar wall when compared with other lung diseases (all p<0.05). Electron microscopy showed apposition of the trophozoite to the type I pneumocyte. Erosion of type I pneumocytes was observed in 13 of 15 patients with P carinii pneumonia, whereas none without P carinii pneumonia had this finding (p<0.05). Erosion of the type II pneumocyte was not observed.
Inflammation, interstitial fibrosis, and alveolar epithelial erosion are characteristic features of P carinii pneumonia. The changes may form the pathologic basis for the respiratory failure seen in patients with P carinii pneumonia. Electron microscopy did not show any diagnostic advantage over conventional light microscopy using routine stains.</description><identifier>ISSN: 0012-3692</identifier><identifier>EISSN: 1931-3543</identifier><identifier>DOI: 10.1378/chest.111.5.1193</identifier><identifier>PMID: 9149569</identifier><identifier>CODEN: CHETBF</identifier><language>eng</language><publisher>Northbrook, IL: Elsevier Inc</publisher><subject>Acquired immune deficiency syndrome ; Adult ; Aged ; AIDS ; AIDS-Related Opportunistic Infections - pathology ; AIDS/HIV ; Antigens ; Biological and medical sciences ; Biopsy ; Bronchoalveolar Lavage Fluid - microbiology ; Bronchoscopy ; Cell Division ; Colony Count, Microbial ; Coloring Agents ; Cytomegalovirus ; Cytoplasm - ultrastructure ; Edema ; Edema - pathology ; Electron microscopes ; electron microscopy ; Epithelium - pathology ; Epithelium - ultrastructure ; Exudates and Transudates ; Female ; Histopathology ; HIV ; Human immunodeficiency virus ; Humans ; Immunodeficiencies ; Immunodeficiencies. Immunoglobulinopathies ; Immunopathology ; Inflammation ; Inflammation - pathology ; Kaposis sarcoma ; Lung diseases ; Lung Diseases - pathology ; Male ; Medical sciences ; Microscopy ; Microscopy, Electron ; Middle Aged ; Organelles - ultrastructure ; Pneumocystis - cytology ; Pneumocystis carinii pneumonia ; Pneumocystis Infections - pathology ; Pneumonia ; Pulmonary Alveoli - pathology ; Pulmonary Alveoli - ultrastructure ; Pulmonary Fibrosis - pathology ; Respiratory Insufficiency - etiology ; Respiratory Insufficiency - pathology ; Stains & staining ; Tuberculosis</subject><ispartof>Chest, 1997-05, Vol.111 (5), p.1193-1199</ispartof><rights>1997 The American College of Chest Physicians</rights><rights>1997 INIST-CNRS</rights><rights>Copyright American College of Chest Physicians May 1997</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c471t-be38da647bf89df454cc8ded28493224d2a3188106ad4a76a7652e77f4b52d1c3</citedby><cites>FETCH-LOGICAL-c471t-be38da647bf89df454cc8ded28493224d2a3188106ad4a76a7652e77f4b52d1c3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=2672406$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/9149569$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Benfield, Thomas L.</creatorcontrib><creatorcontrib>Prentø, Poul</creatorcontrib><creatorcontrib>Junge, Jette</creatorcontrib><creatorcontrib>Vestbo, Jørgen</creatorcontrib><creatorcontrib>Lundgren, Jens D.</creatorcontrib><title>Alveolar Damage in AIDS-Related Pneumocystis carinii Pneumonia</title><title>Chest</title><addtitle>Chest</addtitle><description>Pneumocystis carinii pneumonia is the most common and serious of the pulmonary complications of AIDS. Despite this, many basic aspects in the pathogenesis of HIV-associated P carinii pneumonia are unknown. We therefore undertook a light and electron microscopic study of transbronchial biopsy specimens to compare pathologic features of P carinii pneumonia and other HIV-related lung diseases.
Thirty-seven consecutive HIV-infected patients undergoing a diagnostic bronchoscopy.
P carinii pneumonia was characterized by an increase in inflammation, edema, exudate, fibrosis, type II pneumocyte proliferation, and cellular infiltration of the alveolar wall when compared with other lung diseases (all p<0.05). Electron microscopy showed apposition of the trophozoite to the type I pneumocyte. Erosion of type I pneumocytes was observed in 13 of 15 patients with P carinii pneumonia, whereas none without P carinii pneumonia had this finding (p<0.05). Erosion of the type II pneumocyte was not observed.
Inflammation, interstitial fibrosis, and alveolar epithelial erosion are characteristic features of P carinii pneumonia. The changes may form the pathologic basis for the respiratory failure seen in patients with P carinii pneumonia. Electron microscopy did not show any diagnostic advantage over conventional light microscopy using routine stains.</description><subject>Acquired immune deficiency syndrome</subject><subject>Adult</subject><subject>Aged</subject><subject>AIDS</subject><subject>AIDS-Related Opportunistic Infections - pathology</subject><subject>AIDS/HIV</subject><subject>Antigens</subject><subject>Biological and medical sciences</subject><subject>Biopsy</subject><subject>Bronchoalveolar Lavage Fluid - microbiology</subject><subject>Bronchoscopy</subject><subject>Cell Division</subject><subject>Colony Count, Microbial</subject><subject>Coloring Agents</subject><subject>Cytomegalovirus</subject><subject>Cytoplasm - ultrastructure</subject><subject>Edema</subject><subject>Edema - pathology</subject><subject>Electron microscopes</subject><subject>electron microscopy</subject><subject>Epithelium - pathology</subject><subject>Epithelium - ultrastructure</subject><subject>Exudates and Transudates</subject><subject>Female</subject><subject>Histopathology</subject><subject>HIV</subject><subject>Human immunodeficiency virus</subject><subject>Humans</subject><subject>Immunodeficiencies</subject><subject>Immunodeficiencies. Immunoglobulinopathies</subject><subject>Immunopathology</subject><subject>Inflammation</subject><subject>Inflammation - pathology</subject><subject>Kaposis sarcoma</subject><subject>Lung diseases</subject><subject>Lung Diseases - pathology</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Microscopy</subject><subject>Microscopy, Electron</subject><subject>Middle Aged</subject><subject>Organelles - ultrastructure</subject><subject>Pneumocystis - cytology</subject><subject>Pneumocystis carinii pneumonia</subject><subject>Pneumocystis Infections - pathology</subject><subject>Pneumonia</subject><subject>Pulmonary Alveoli - pathology</subject><subject>Pulmonary Alveoli - ultrastructure</subject><subject>Pulmonary Fibrosis - pathology</subject><subject>Respiratory Insufficiency - etiology</subject><subject>Respiratory Insufficiency - pathology</subject><subject>Stains & staining</subject><subject>Tuberculosis</subject><issn>0012-3692</issn><issn>1931-3543</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1997</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNp1UFtrFDEUDmKpa_XdF2EQ8W22uV98EJbWS6GgeHkO2eRMNyUz0yYzlf57U3eoWCiEE07Odzn5EHpF8JowpY_9Dsq0JoSsRa2GPUGrWknLBGdP0QpjQlsmDX2GnpdyiWtPjDxEh4ZwI6RZoQ-bdANjcrk5db27gCYOzebs9Ef7HZKbIDTfBpj70d-WKZbGuxyHGJfHIboX6KBzqcDL5T5Cvz59_HnypT3_-vnsZHPeeq7I1G6B6eAkV9tOm9Bxwb3XAQLV3DBKeaCOEa0Jli5wp2Q9goJSHd8KGohnR-jdXvcqj9dz_bPtY_GQkhtgnItV2miBiarANw-Al-Och7qbpRgzI7TkFYT3IJ_HUjJ09irH3uVbS7C9y9X-zdXWXK2wd7lWyutFd972EO4JS5B1_naZu-Jd6rIbfCz3MCoV5Vj-c97Fi93vmMGW3qVURdnec9n2P-f3ewrUfG8iZFt8hMFDqHQ_2TDGx9f-A0KfpGg</recordid><startdate>19970501</startdate><enddate>19970501</enddate><creator>Benfield, Thomas L.</creator><creator>Prentø, Poul</creator><creator>Junge, Jette</creator><creator>Vestbo, Jørgen</creator><creator>Lundgren, Jens D.</creator><general>Elsevier Inc</general><general>American College of Chest Physicians</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9-</scope><scope>K9.</scope><scope>KB0</scope><scope>M0R</scope><scope>M0S</scope><scope>M1P</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>7X8</scope></search><sort><creationdate>19970501</creationdate><title>Alveolar Damage in AIDS-Related Pneumocystis carinii Pneumonia</title><author>Benfield, Thomas L. ; Prentø, Poul ; Junge, Jette ; Vestbo, Jørgen ; Lundgren, Jens D.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c471t-be38da647bf89df454cc8ded28493224d2a3188106ad4a76a7652e77f4b52d1c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1997</creationdate><topic>Acquired immune deficiency syndrome</topic><topic>Adult</topic><topic>Aged</topic><topic>AIDS</topic><topic>AIDS-Related Opportunistic Infections - pathology</topic><topic>AIDS/HIV</topic><topic>Antigens</topic><topic>Biological and medical sciences</topic><topic>Biopsy</topic><topic>Bronchoalveolar Lavage Fluid - microbiology</topic><topic>Bronchoscopy</topic><topic>Cell Division</topic><topic>Colony Count, Microbial</topic><topic>Coloring Agents</topic><topic>Cytomegalovirus</topic><topic>Cytoplasm - ultrastructure</topic><topic>Edema</topic><topic>Edema - pathology</topic><topic>Electron microscopes</topic><topic>electron microscopy</topic><topic>Epithelium - pathology</topic><topic>Epithelium - ultrastructure</topic><topic>Exudates and Transudates</topic><topic>Female</topic><topic>Histopathology</topic><topic>HIV</topic><topic>Human immunodeficiency virus</topic><topic>Humans</topic><topic>Immunodeficiencies</topic><topic>Immunodeficiencies. Immunoglobulinopathies</topic><topic>Immunopathology</topic><topic>Inflammation</topic><topic>Inflammation - pathology</topic><topic>Kaposis sarcoma</topic><topic>Lung diseases</topic><topic>Lung Diseases - pathology</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Microscopy</topic><topic>Microscopy, Electron</topic><topic>Middle Aged</topic><topic>Organelles - ultrastructure</topic><topic>Pneumocystis - cytology</topic><topic>Pneumocystis carinii pneumonia</topic><topic>Pneumocystis Infections - pathology</topic><topic>Pneumonia</topic><topic>Pulmonary Alveoli - pathology</topic><topic>Pulmonary Alveoli - ultrastructure</topic><topic>Pulmonary Fibrosis - pathology</topic><topic>Respiratory Insufficiency - etiology</topic><topic>Respiratory Insufficiency - pathology</topic><topic>Stains & staining</topic><topic>Tuberculosis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Benfield, Thomas L.</creatorcontrib><creatorcontrib>Prentø, Poul</creatorcontrib><creatorcontrib>Junge, Jette</creatorcontrib><creatorcontrib>Vestbo, Jørgen</creatorcontrib><creatorcontrib>Lundgren, Jens D.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Nursing & Allied Health Database</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>Consumer Health Database (Alumni Edition)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Consumer Health Database</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>MEDLINE - Academic</collection><jtitle>Chest</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Benfield, Thomas L.</au><au>Prentø, Poul</au><au>Junge, Jette</au><au>Vestbo, Jørgen</au><au>Lundgren, Jens D.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Alveolar Damage in AIDS-Related Pneumocystis carinii Pneumonia</atitle><jtitle>Chest</jtitle><addtitle>Chest</addtitle><date>1997-05-01</date><risdate>1997</risdate><volume>111</volume><issue>5</issue><spage>1193</spage><epage>1199</epage><pages>1193-1199</pages><issn>0012-3692</issn><eissn>1931-3543</eissn><coden>CHETBF</coden><abstract>Pneumocystis carinii pneumonia is the most common and serious of the pulmonary complications of AIDS. Despite this, many basic aspects in the pathogenesis of HIV-associated P carinii pneumonia are unknown. We therefore undertook a light and electron microscopic study of transbronchial biopsy specimens to compare pathologic features of P carinii pneumonia and other HIV-related lung diseases.
Thirty-seven consecutive HIV-infected patients undergoing a diagnostic bronchoscopy.
P carinii pneumonia was characterized by an increase in inflammation, edema, exudate, fibrosis, type II pneumocyte proliferation, and cellular infiltration of the alveolar wall when compared with other lung diseases (all p<0.05). Electron microscopy showed apposition of the trophozoite to the type I pneumocyte. Erosion of type I pneumocytes was observed in 13 of 15 patients with P carinii pneumonia, whereas none without P carinii pneumonia had this finding (p<0.05). Erosion of the type II pneumocyte was not observed.
Inflammation, interstitial fibrosis, and alveolar epithelial erosion are characteristic features of P carinii pneumonia. The changes may form the pathologic basis for the respiratory failure seen in patients with P carinii pneumonia. Electron microscopy did not show any diagnostic advantage over conventional light microscopy using routine stains.</abstract><cop>Northbrook, IL</cop><pub>Elsevier Inc</pub><pmid>9149569</pmid><doi>10.1378/chest.111.5.1193</doi><tpages>7</tpages></addata></record> |
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| subjects | Acquired immune deficiency syndrome Adult Aged AIDS AIDS-Related Opportunistic Infections - pathology AIDS/HIV Antigens Biological and medical sciences Biopsy Bronchoalveolar Lavage Fluid - microbiology Bronchoscopy Cell Division Colony Count, Microbial Coloring Agents Cytomegalovirus Cytoplasm - ultrastructure Edema Edema - pathology Electron microscopes electron microscopy Epithelium - pathology Epithelium - ultrastructure Exudates and Transudates Female Histopathology HIV Human immunodeficiency virus Humans Immunodeficiencies Immunodeficiencies. Immunoglobulinopathies Immunopathology Inflammation Inflammation - pathology Kaposis sarcoma Lung diseases Lung Diseases - pathology Male Medical sciences Microscopy Microscopy, Electron Middle Aged Organelles - ultrastructure Pneumocystis - cytology Pneumocystis carinii pneumonia Pneumocystis Infections - pathology Pneumonia Pulmonary Alveoli - pathology Pulmonary Alveoli - ultrastructure Pulmonary Fibrosis - pathology Respiratory Insufficiency - etiology Respiratory Insufficiency - pathology Stains & staining Tuberculosis |
| title | Alveolar Damage in AIDS-Related Pneumocystis carinii Pneumonia |
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