Airway secretory IgA concentrations in patients with lung cancer. Evaluation of the uninvolved lung
To determine whether concentrations of the primary airway immunoglobulins (SIgA, IgG) are altered in the uninvolved lung of patients with lung cancer, we determined concentrations of SIgA and IgG in bronchial washings recovered from a proximal airway of the uninvolved lung in 24 patients with lung c...
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| Veröffentlicht in: | Chest 1989-06, Vol.95 (6), p.1265-1268 |
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| container_title | Chest |
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| creator | Wesselius, L J Dark, D S Hanson, F N Wheaton, D L |
| description | To determine whether concentrations of the primary airway immunoglobulins (SIgA, IgG) are altered in the uninvolved lung of
patients with lung cancer, we determined concentrations of SIgA and IgG in bronchial washings recovered from a proximal airway
of the uninvolved lung in 24 patients with lung cancer and in ten patients with benign lung disease. When standardized for
the amount of total protein recovered (SIgA/TP, IgG/TP), bronchial washings recovered from the uninvolved lung of lung cancer
patients demonstrated a significantly decreased SIgA/TP ratio compared to control subjects (.14 +/- .02 vs .31 +/- .05, SEM,
p less than 0.05). There were no differences in the IgG/TP ratios. Lung cancer patients with a decreased serum albumin (less
than 3.2 g/dl) had a significantly decreased SIgA/TP ratio in bronchial washings compared to patients with a higher serum
albumin (.08 +/- .03 vs .18 +/- .04, SEM, p less than 0.05). The decreased relative concentration of airway SIgA in lung cancer
patients may adversely affect airway defenses against bacterial colonization. |
| doi_str_mv | 10.1378/chest.95.6.1265 |
| format | Article |
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patients with lung cancer, we determined concentrations of SIgA and IgG in bronchial washings recovered from a proximal airway
of the uninvolved lung in 24 patients with lung cancer and in ten patients with benign lung disease. When standardized for
the amount of total protein recovered (SIgA/TP, IgG/TP), bronchial washings recovered from the uninvolved lung of lung cancer
patients demonstrated a significantly decreased SIgA/TP ratio compared to control subjects (.14 +/- .02 vs .31 +/- .05, SEM,
p less than 0.05). There were no differences in the IgG/TP ratios. Lung cancer patients with a decreased serum albumin (less
than 3.2 g/dl) had a significantly decreased SIgA/TP ratio in bronchial washings compared to patients with a higher serum
albumin (.08 +/- .03 vs .18 +/- .04, SEM, p less than 0.05). The decreased relative concentration of airway SIgA in lung cancer
patients may adversely affect airway defenses against bacterial colonization.</description><identifier>ISSN: 0012-3692</identifier><identifier>EISSN: 1931-3543</identifier><identifier>DOI: 10.1378/chest.95.6.1265</identifier><identifier>PMID: 2721263</identifier><language>eng</language><publisher>United States: American College of Chest Physicians</publisher><subject>Bronchi - immunology ; Bronchoscopy ; Carcinoma, Bronchogenic - immunology ; Enzyme-Linked Immunosorbent Assay ; Humans ; Immunoglobulin A, Secretory - analysis ; Immunoglobulin G - analysis ; Lung - immunology ; Lung Neoplasms - immunology ; Male ; Middle Aged ; Serum Albumin</subject><ispartof>Chest, 1989-06, Vol.95 (6), p.1265-1268</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,777,781,27905,27906</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/2721263$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Wesselius, L J</creatorcontrib><creatorcontrib>Dark, D S</creatorcontrib><creatorcontrib>Hanson, F N</creatorcontrib><creatorcontrib>Wheaton, D L</creatorcontrib><title>Airway secretory IgA concentrations in patients with lung cancer. Evaluation of the uninvolved lung</title><title>Chest</title><addtitle>Chest</addtitle><description>To determine whether concentrations of the primary airway immunoglobulins (SIgA, IgG) are altered in the uninvolved lung of
patients with lung cancer, we determined concentrations of SIgA and IgG in bronchial washings recovered from a proximal airway
of the uninvolved lung in 24 patients with lung cancer and in ten patients with benign lung disease. When standardized for
the amount of total protein recovered (SIgA/TP, IgG/TP), bronchial washings recovered from the uninvolved lung of lung cancer
patients demonstrated a significantly decreased SIgA/TP ratio compared to control subjects (.14 +/- .02 vs .31 +/- .05, SEM,
p less than 0.05). There were no differences in the IgG/TP ratios. Lung cancer patients with a decreased serum albumin (less
than 3.2 g/dl) had a significantly decreased SIgA/TP ratio in bronchial washings compared to patients with a higher serum
albumin (.08 +/- .03 vs .18 +/- .04, SEM, p less than 0.05). The decreased relative concentration of airway SIgA in lung cancer
patients may adversely affect airway defenses against bacterial colonization.</description><subject>Bronchi - immunology</subject><subject>Bronchoscopy</subject><subject>Carcinoma, Bronchogenic - immunology</subject><subject>Enzyme-Linked Immunosorbent Assay</subject><subject>Humans</subject><subject>Immunoglobulin A, Secretory - analysis</subject><subject>Immunoglobulin G - analysis</subject><subject>Lung - immunology</subject><subject>Lung Neoplasms - immunology</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Serum Albumin</subject><issn>0012-3692</issn><issn>1931-3543</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1989</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNotkM1PwyAchonRzDk9ezLh5K1dgQLluCxTlyzxomeClK4slE5ot-y_F7edfh_vk_fwAPCMihwRXs11a-KQC5qzHGFGb8AUCYIyQktyC6ZFgXBGmMD34CHGXZFuJNgETDDHCSdToBc2HNUJRqODGfpwguvtAurea-OHoAbb-with_u0pk-ERzu00I1-C7VKUMjh6qDceCZh38ChNXD01h96dzD1mXwEd41y0Txd5wx8v62-lh_Z5vN9vVxsshaXbMhqUxS8QKpkuKSEMKNKIypcV6JSvKy1aJoKY85KjpVQGPGaqkZwiiknNVKYzMDrpXcf-t8xeZGdjdo4p7zpxyh5akrlNIEvV3D86Uwt98F2Kpzk1UrK55e8tdv2aIORsVPOJZrIs_BdPwavnKCSyX_t5A87IHYB</recordid><startdate>19890601</startdate><enddate>19890601</enddate><creator>Wesselius, L J</creator><creator>Dark, D S</creator><creator>Hanson, F N</creator><creator>Wheaton, D L</creator><general>American College of Chest Physicians</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>19890601</creationdate><title>Airway secretory IgA concentrations in patients with lung cancer. Evaluation of the uninvolved lung</title><author>Wesselius, L J ; Dark, D S ; Hanson, F N ; Wheaton, D L</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-h246t-de00701a46245336ea4e982d898a74dc9ff82276472a9a217d5af9752573d1a23</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1989</creationdate><topic>Bronchi - immunology</topic><topic>Bronchoscopy</topic><topic>Carcinoma, Bronchogenic - immunology</topic><topic>Enzyme-Linked Immunosorbent Assay</topic><topic>Humans</topic><topic>Immunoglobulin A, Secretory - analysis</topic><topic>Immunoglobulin G - analysis</topic><topic>Lung - immunology</topic><topic>Lung Neoplasms - immunology</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Serum Albumin</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Wesselius, L J</creatorcontrib><creatorcontrib>Dark, D S</creatorcontrib><creatorcontrib>Hanson, F N</creatorcontrib><creatorcontrib>Wheaton, D L</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>Chest</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Wesselius, L J</au><au>Dark, D S</au><au>Hanson, F N</au><au>Wheaton, D L</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Airway secretory IgA concentrations in patients with lung cancer. Evaluation of the uninvolved lung</atitle><jtitle>Chest</jtitle><addtitle>Chest</addtitle><date>1989-06-01</date><risdate>1989</risdate><volume>95</volume><issue>6</issue><spage>1265</spage><epage>1268</epage><pages>1265-1268</pages><issn>0012-3692</issn><eissn>1931-3543</eissn><abstract>To determine whether concentrations of the primary airway immunoglobulins (SIgA, IgG) are altered in the uninvolved lung of
patients with lung cancer, we determined concentrations of SIgA and IgG in bronchial washings recovered from a proximal airway
of the uninvolved lung in 24 patients with lung cancer and in ten patients with benign lung disease. When standardized for
the amount of total protein recovered (SIgA/TP, IgG/TP), bronchial washings recovered from the uninvolved lung of lung cancer
patients demonstrated a significantly decreased SIgA/TP ratio compared to control subjects (.14 +/- .02 vs .31 +/- .05, SEM,
p less than 0.05). There were no differences in the IgG/TP ratios. Lung cancer patients with a decreased serum albumin (less
than 3.2 g/dl) had a significantly decreased SIgA/TP ratio in bronchial washings compared to patients with a higher serum
albumin (.08 +/- .03 vs .18 +/- .04, SEM, p less than 0.05). The decreased relative concentration of airway SIgA in lung cancer
patients may adversely affect airway defenses against bacterial colonization.</abstract><cop>United States</cop><pub>American College of Chest Physicians</pub><pmid>2721263</pmid><doi>10.1378/chest.95.6.1265</doi><tpages>4</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0012-3692 |
| ispartof | Chest, 1989-06, Vol.95 (6), p.1265-1268 |
| issn | 0012-3692 1931-3543 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_78984625 |
| source | MEDLINE; Alma/SFX Local Collection |
| subjects | Bronchi - immunology Bronchoscopy Carcinoma, Bronchogenic - immunology Enzyme-Linked Immunosorbent Assay Humans Immunoglobulin A, Secretory - analysis Immunoglobulin G - analysis Lung - immunology Lung Neoplasms - immunology Male Middle Aged Serum Albumin |
| title | Airway secretory IgA concentrations in patients with lung cancer. Evaluation of the uninvolved lung |
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