Selective chromosomal damage and cytotoxicity of 125I-labeled monoclonal antibody 17-1a in human cancer cells

A monoclonal antibody, 17-1a, which reacts with antigen expressed in human colon cancers was radiolabeled in high specific activity with 125I. The combination of the antibody and this radionuclide was observed to elicit specific cellular damage after being internalized into cells of the SW1116 human...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Cancer research (Chicago, Ill.) Ill.), 1989-06, Vol.49 (11), p.2952-2958
Hauptverfasser:	WOO, D. V, DERUI LI, MATTIS, J. A, STEPLEWSKI, Z
Format:	Artikel
Sprache:	eng
Schlagworte:	Antibodies, Monoclonal - therapeutic use Antigens, Neoplasm - immunology Antigens, Neoplasm - metabolism Antineoplastic agents Biological and medical sciences Cell Survival - drug effects Chromosome Aberrations Colonic Neoplasms - genetics Colonic Neoplasms - metabolism Colonic Neoplasms - therapy DNA Damage DNA, Neoplasm - drug effects DNA, Neoplasm - metabolism General aspects Humans Iodine Radioisotopes Medical sciences Pharmacology. Drug treatments Tumor Cells, Cultured - metabolism
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!