Pituitary adenylate cyclase-activating polypeptide promotes cell survival and neurite outgrowth in rat cerebellar neuroblasts

High concentrations of pituitary adenylate cyclase-activating polypeptide (PACAP) and its receptors have been detected in the rat cerebellum during ontogenesis. In particular, PACAP receptors are actively expressed in immature granule cells, suggesting that PACAP may act as a neurotrophic factor in...

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Veröffentlicht in:	Neuroscience 1997-05, Vol.78 (2), p.419-430
Hauptverfasser:	Gonzalez, B.J, Basille, M, Vaudry, D, Fournier, A, Vaudry, H
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals apoptosis Biological and medical sciences Cell Count Cell Survival - drug effects Cells, Cultured cerebellar granule cells Cerebellum - cytology Cerebellum - drug effects Cerebellum - growth & development Development. Senescence. Regeneration. Transplantation Fundamental and applied biological sciences. Psychology Neurites - drug effects Neurofilament Proteins - metabolism Neurons - drug effects Neuropeptides - pharmacology neurotrophic activity PACAP Pituitary Adenylate Cyclase-Activating Polypeptide Potassium Chloride - pharmacology Rats Rats, Wistar Vasoactive Intestinal Peptide - pharmacology Vertebrates: nervous system and sense organs
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