Structural Basis of DNA Bending and Oriented Heterodimer Binding by the Basic Leucine Zipper Domains of Fos and Jun

Interactions among transcription factors that bind to separate sequence elements require bending of the intervening DNA and juxtaposition of interacting molecular surfaces in an appropriate orientation. Here, we examine the effects of single amino acid substitutions adjacent to the basic regions of...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 1997-05, Vol.94 (10), p.4913-4918
Hauptverfasser:	Leonard, David A., Rajaram, Nirmala, Kerppola, Tom K.
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Amino acid substitution Amino acids Base Sequence Bending Binding Sites Biochemistry Biological Sciences Chemical bases Cloning, Molecular Deoxyribonucleic acid Dimerization DNA DNA - chemistry DNA - metabolism DNA probes Electrostatics Escherichia coli Genetic mutation Genetic variation Leucine Zippers Models, Structural Molecular Sequence Data Nucleic Acid Conformation Nucleic Acid Heteroduplexes - chemistry Nucleic Acid Heteroduplexes - metabolism Polymerase Chain Reaction Protein Structure, Secondary Proteins Proto-Oncogene Proteins c-fos - chemistry Proto-Oncogene Proteins c-fos - isolation & purification Proto-Oncogene Proteins c-fos - metabolism Proto-Oncogene Proteins c-jun - chemistry Proto-Oncogene Proteins c-jun - isolation & purification Proto-Oncogene Proteins c-jun - metabolism Recombinant Proteins - chemistry Recombinant Proteins - isolation & purification Recombinant Proteins - metabolism Transcription Factor AP-1 - metabolism
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