A histopathologic study of oral mucosal lupus erythematosus
Specimens representing 17 cases of each of oral mucosal lupus erythematosus (LE) and lichen planus were examined under the light microscope to establish a set of histopathologic criteria that would distinguish between the two. Statistical analysis showed that significant differences in histopatholog...
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| Veröffentlicht in: | Oral surgery, oral medicine, oral pathology oral medicine, oral pathology, 1989-05, Vol.67 (5), p.547-554 |
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| container_title | Oral surgery, oral medicine, oral pathology |
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| creator | Karjalainen, Tuomo K. Tomich, Charles E. |
| description | Specimens representing 17 cases of each of oral mucosal lupus erythematosus (LE) and lichen planus were examined under the light microscope to establish a set of histopathologic criteria that would distinguish between the two. Statistical analysis showed that significant differences in histopathology exist between the two diseases. A classic case of LE was found to exhibit the following characteristics: vacuolization of keratinocytes, patchy PAS-positive deposits subepithelially, edema in the lamina propria, PAS-positive thickening of blood vessel walls, and the presence of a severe or perivascular inflammatory cell infiltrate. A number of other less significant alterations were also identified. It is concluded from this study that oral LE in most cases is characteristic enough to provide a definitive diagnosis at the light microscopic level. |
| doi_str_mv | 10.1016/0030-4220(89)90271-5 |
| format | Article |
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Statistical analysis showed that significant differences in histopathology exist between the two diseases. A classic case of LE was found to exhibit the following characteristics: vacuolization of keratinocytes, patchy PAS-positive deposits subepithelially, edema in the lamina propria, PAS-positive thickening of blood vessel walls, and the presence of a severe or perivascular inflammatory cell infiltrate. A number of other less significant alterations were also identified. It is concluded from this study that oral LE in most cases is characteristic enough to provide a definitive diagnosis at the light microscopic level.</description><identifier>ISSN: 0030-4220</identifier><identifier>EISSN: 1878-2175</identifier><identifier>DOI: 10.1016/0030-4220(89)90271-5</identifier><identifier>PMID: 2717152</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Adult ; Aged ; Atrophy ; Blood Vessels - pathology ; Connective Tissue - pathology ; Dentistry ; Diagnosis, Differential ; Edema - pathology ; Epithelium - pathology ; Female ; Humans ; Hyperplasia ; Lichen Planus - pathology ; Lupus Erythematosus, Discoid - pathology ; Lupus Erythematosus, Systemic - pathology ; Male ; Middle Aged ; Mouth Diseases - pathology ; Mouth Mucosa - blood supply ; Mouth Mucosa - pathology</subject><ispartof>Oral surgery, oral medicine, oral pathology, 1989-05, Vol.67 (5), p.547-554</ispartof><rights>1989</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c423t-fecd13238576306383a43668ceb1e9d2e39a3bc3bd000b677beeaa4c0829cef73</citedby><cites>FETCH-LOGICAL-c423t-fecd13238576306383a43668ceb1e9d2e39a3bc3bd000b677beeaa4c0829cef73</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/2717152$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Karjalainen, Tuomo K.</creatorcontrib><creatorcontrib>Tomich, Charles E.</creatorcontrib><title>A histopathologic study of oral mucosal lupus erythematosus</title><title>Oral surgery, oral medicine, oral pathology</title><addtitle>Oral Surg Oral Med Oral Pathol</addtitle><description>Specimens representing 17 cases of each of oral mucosal lupus erythematosus (LE) and lichen planus were examined under the light microscope to establish a set of histopathologic criteria that would distinguish between the two. Statistical analysis showed that significant differences in histopathology exist between the two diseases. A classic case of LE was found to exhibit the following characteristics: vacuolization of keratinocytes, patchy PAS-positive deposits subepithelially, edema in the lamina propria, PAS-positive thickening of blood vessel walls, and the presence of a severe or perivascular inflammatory cell infiltrate. A number of other less significant alterations were also identified. It is concluded from this study that oral LE in most cases is characteristic enough to provide a definitive diagnosis at the light microscopic level.</description><subject>Adult</subject><subject>Aged</subject><subject>Atrophy</subject><subject>Blood Vessels - pathology</subject><subject>Connective Tissue - pathology</subject><subject>Dentistry</subject><subject>Diagnosis, Differential</subject><subject>Edema - pathology</subject><subject>Epithelium - pathology</subject><subject>Female</subject><subject>Humans</subject><subject>Hyperplasia</subject><subject>Lichen Planus - pathology</subject><subject>Lupus Erythematosus, Discoid - pathology</subject><subject>Lupus Erythematosus, Systemic - pathology</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Mouth Diseases - pathology</subject><subject>Mouth Mucosa - blood supply</subject><subject>Mouth Mucosa - pathology</subject><issn>0030-4220</issn><issn>1878-2175</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1989</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kEtLw0AQxxdRaq1-A4WcRA_RfSS7GwShFF9Q8KLnZbOZ2JXEjfsQ-u1NbenR0zD8H8P8EDon-IZgwm8xZjgvKMVXsrquMBUkLw_QlEghc0pEeYime8sxOgnhc1xFwdkETUazICWdort5trIhukHHlevchzVZiKlZZ67NnNdd1ifjwji7NKSQgV_HFfQ6upDCKTpqdRfgbDdn6P3x4W3xnC9fn14W82VuCspi3oJpCKNMloIzzJlkumCcSwM1gaqhwCrNasPqBmNccyFqAK0LgyWtDLSCzdDltnfw7jtBiKq3wUDX6S9wKSghK1HxEo_GYms03oXgoVWDt732a0Ww2jBTGyBqA0TJSv0xU-UYu9j1p7qHZh_aQRr1-60O45M_FrwKxsKXgcZ6MFE1zv5_4Be6Pnsk</recordid><startdate>19890501</startdate><enddate>19890501</enddate><creator>Karjalainen, Tuomo K.</creator><creator>Tomich, Charles E.</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19890501</creationdate><title>A histopathologic study of oral mucosal lupus erythematosus</title><author>Karjalainen, Tuomo K. ; Tomich, Charles E.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c423t-fecd13238576306383a43668ceb1e9d2e39a3bc3bd000b677beeaa4c0829cef73</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1989</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Atrophy</topic><topic>Blood Vessels - pathology</topic><topic>Connective Tissue - pathology</topic><topic>Dentistry</topic><topic>Diagnosis, Differential</topic><topic>Edema - pathology</topic><topic>Epithelium - pathology</topic><topic>Female</topic><topic>Humans</topic><topic>Hyperplasia</topic><topic>Lichen Planus - pathology</topic><topic>Lupus Erythematosus, Discoid - pathology</topic><topic>Lupus Erythematosus, Systemic - pathology</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Mouth Diseases - pathology</topic><topic>Mouth Mucosa - blood supply</topic><topic>Mouth Mucosa - pathology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Karjalainen, Tuomo K.</creatorcontrib><creatorcontrib>Tomich, Charles E.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Oral surgery, oral medicine, oral pathology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Karjalainen, Tuomo K.</au><au>Tomich, Charles E.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A histopathologic study of oral mucosal lupus erythematosus</atitle><jtitle>Oral surgery, oral medicine, oral pathology</jtitle><addtitle>Oral Surg Oral Med Oral Pathol</addtitle><date>1989-05-01</date><risdate>1989</risdate><volume>67</volume><issue>5</issue><spage>547</spage><epage>554</epage><pages>547-554</pages><issn>0030-4220</issn><eissn>1878-2175</eissn><abstract>Specimens representing 17 cases of each of oral mucosal lupus erythematosus (LE) and lichen planus were examined under the light microscope to establish a set of histopathologic criteria that would distinguish between the two. Statistical analysis showed that significant differences in histopathology exist between the two diseases. A classic case of LE was found to exhibit the following characteristics: vacuolization of keratinocytes, patchy PAS-positive deposits subepithelially, edema in the lamina propria, PAS-positive thickening of blood vessel walls, and the presence of a severe or perivascular inflammatory cell infiltrate. A number of other less significant alterations were also identified. It is concluded from this study that oral LE in most cases is characteristic enough to provide a definitive diagnosis at the light microscopic level.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>2717152</pmid><doi>10.1016/0030-4220(89)90271-5</doi><tpages>8</tpages></addata></record> |
| fulltext | fulltext |
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| ispartof | Oral surgery, oral medicine, oral pathology, 1989-05, Vol.67 (5), p.547-554 |
| issn | 0030-4220 1878-2175 |
| language | eng |
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| source | MEDLINE; Alma/SFX Local Collection |
| subjects | Adult Aged Atrophy Blood Vessels - pathology Connective Tissue - pathology Dentistry Diagnosis, Differential Edema - pathology Epithelium - pathology Female Humans Hyperplasia Lichen Planus - pathology Lupus Erythematosus, Discoid - pathology Lupus Erythematosus, Systemic - pathology Male Middle Aged Mouth Diseases - pathology Mouth Mucosa - blood supply Mouth Mucosa - pathology |
| title | A histopathologic study of oral mucosal lupus erythematosus |
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