Population pharmacokinetics of sirolimus in kidney transplant patients

Objective To characterize the dose‐related pharmacokinetics of the immunosuppressant agent sirolimus (formerly rapamycin) in kidney transplant patients by use of two‐stage and nonlinear mixed‐effect model population methods. Methods Patients (n = 36) from three centers (Germany, the United Kingdom,...

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Veröffentlicht in:	Clinical pharmacology and therapeutics 1997-04, Vol.61 (4), p.416-428
Hauptverfasser:	Ferron, Geraldine M., Mishina, Elena V., Zimmerman, James J., Jusko, William J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Biological and medical sciences Body Surface Area Body Weight Cyclosporine - pharmacology Female Half-Life Humans Immunomodulators Immunosuppressive Agents - blood Immunosuppressive Agents - pharmacokinetics Immunosuppressive Agents - pharmacology Kidney Transplantation Male Medical sciences Middle Aged Models, Statistical Pharmacology. Drug treatments Polyenes - blood Polyenes - pharmacokinetics Sirolimus Tacrolimus - pharmacokinetics
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