Scrapie susceptibility-linked polymorphisms modulate the in vitro conversion of sheep prion protein to protease-resistant forms

Prion diseases are natural transmissible neurodegenerative disorders in humans and animals. They are characterized by the accumulation of a protease-resistant scrapie-associated prion protein (PrP Sc ) of the host-encoded cellular prion protein (PrP C ) mainly in the central nervous system. Polymorp...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 1997-05, Vol.94 (10), p.4931-4936
Hauptverfasser:	Bossers, A, Belt PBGM, Raymond, G J, Caughey, B, de Vries, R, Smits, M A
Format:	Artikel
Sprache:	eng
Schlagworte:	Alleles Animals Biochemistry Biological Sciences Brain - virology Cell-Free System Cytomegalovirus Disease Disease Susceptibility Endopeptidase K - metabolism Genetic Variation Genetic Vectors Genotype Humans ID Lelystad, Institute for Animal Science and Health ID-Lelystad, Instituut voor Dierhouderij en Diergezondheid Mice Neuroblastoma Polymorphism, Genetic Prions - biosynthesis Prions - genetics Prions - metabolism Proteins Recombinant Proteins - biosynthesis Recombinant Proteins - metabolism Scrapie - genetics Sheep Tumor Cells, Cultured
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