Autoradiographic localization of sigma opioid receptors in the gastrointestinal tract of the guinea pig
The distribution of σ and phencyclidine binding sites in the gastrointestinal tract of the guinea pig was studied by autoradiography after in vitro incubation of tissue slices with (+)3H-SKF 10,047 and 3H-1-1-[(2-thienyl)cyclohexyl] piperidine to locate σ and phencyclidine receptors, respectively. A...
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| Veröffentlicht in: | Gastroenterology (New York, N.Y. 1943) N.Y. 1943), 1989-07, Vol.97 (1), p.76-82 |
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| container_end_page | 82 |
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| container_title | Gastroenterology (New York, N.Y. 1943) |
| container_volume | 97 |
| creator | Roman, F. Pascaud, X. Chomette, G. Bueno, L. Junien, J.L. |
| description | The distribution of σ and phencyclidine binding sites in the gastrointestinal tract of the guinea pig was studied by autoradiography after in vitro incubation of tissue slices with (+)3H-SKF 10,047 and 3H-1-1-[(2-thienyl)cyclohexyl] piperidine to locate σ and phencyclidine receptors, respectively. A dense distribution of σ binding sites was observed in the mucosa and in the submucosal plexus, particularly at the level of the fundus and duodenum. Muscular layers were only marginally labeled. No phencyclidine binding site could be demonstrated in any area. This selective distribution suggests a functional role of σ receptors mainly in the control of endocrine or exocrine secretions, or both. |
| doi_str_mv | 10.1016/0016-5085(89)91418-2 |
| format | Article |
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A dense distribution of σ binding sites was observed in the mucosa and in the submucosal plexus, particularly at the level of the fundus and duodenum. Muscular layers were only marginally labeled. No phencyclidine binding site could be demonstrated in any area. This selective distribution suggests a functional role of σ receptors mainly in the control of endocrine or exocrine secretions, or both.</description><identifier>ISSN: 0016-5085</identifier><identifier>EISSN: 1528-0012</identifier><identifier>DOI: 10.1016/0016-5085(89)91418-2</identifier><identifier>PMID: 2542120</identifier><identifier>CODEN: GASTAB</identifier><language>eng</language><publisher>New York, NY: Elsevier Inc</publisher><subject>Animals ; Autoradiography ; Biological and medical sciences ; Digestive System - analysis ; Fundamental and applied biological sciences. 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A dense distribution of σ binding sites was observed in the mucosa and in the submucosal plexus, particularly at the level of the fundus and duodenum. Muscular layers were only marginally labeled. No phencyclidine binding site could be demonstrated in any area. This selective distribution suggests a functional role of σ receptors mainly in the control of endocrine or exocrine secretions, or both.</description><subject>Animals</subject><subject>Autoradiography</subject><subject>Biological and medical sciences</subject><subject>Digestive System - analysis</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Guinea Pigs</subject><subject>Intestinal Mucosa - analysis</subject><subject>Male</subject><subject>Phencyclidine - analysis</subject><subject>Receptors, Neurotransmitter - analysis</subject><subject>Receptors, Opioid - analysis</subject><subject>Receptors, Phencyclidine</subject><subject>Receptors, sigma</subject><subject>Stomach</subject><subject>Vertebrates: digestive system</subject><issn>0016-5085</issn><issn>1528-0012</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1989</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kEFrFDEYhoModVv9Bwo5iNTD1CSTzCaXQilqhUIveg6Z5JvpJ7OTMckI9deb7S579JIc3uf9eHkIecfZFWe8-8zq0yim1aU2nwyXXDfiBdlwJXRTM_GSbE7Ia3Ke8y_GmGk1PyNnQknBBduQ8WYtMbmAcUxueURPp-jdhH9dwTjTONCM487RuGDEQBN4WGohU5xpeQQ6ulxSxLlALji7iZbkfNn3ntMVZ3B0wfENeTW4KcPb439Bfn798uP2rrl_-Pb99ua-8dLo0tTxgemhNZ3wWvU9uF4IafwAWgUnmfSd3lZA9QNvA5dDaFVveNdLHqATqr0gHw93lxR_r3WU3WH2ME1uhrhmu9VmqzlrKygPoE8x5wSDXRLuXHqynNm9X7uXZ_fyrDb22a8Vtfb-eH_tdxBOpaPQmn845i5Xj0Nys8d8wrquY4LJil0fMKgu_iAkmz3C7CFgVVxsiPj_Hf8A1UWX0w</recordid><startdate>19890701</startdate><enddate>19890701</enddate><creator>Roman, F.</creator><creator>Pascaud, X.</creator><creator>Chomette, G.</creator><creator>Bueno, L.</creator><creator>Junien, J.L.</creator><general>Elsevier Inc</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19890701</creationdate><title>Autoradiographic localization of sigma opioid receptors in the gastrointestinal tract of the guinea pig</title><author>Roman, F. ; Pascaud, X. ; Chomette, G. ; Bueno, L. ; Junien, J.L.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c498t-152d08f3962c85bbeab2249cfe85da404c68708f5bf13d14fd35b916b41de6253</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1989</creationdate><topic>Animals</topic><topic>Autoradiography</topic><topic>Biological and medical sciences</topic><topic>Digestive System - analysis</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Guinea Pigs</topic><topic>Intestinal Mucosa - analysis</topic><topic>Male</topic><topic>Phencyclidine - analysis</topic><topic>Receptors, Neurotransmitter - analysis</topic><topic>Receptors, Opioid - analysis</topic><topic>Receptors, Phencyclidine</topic><topic>Receptors, sigma</topic><topic>Stomach</topic><topic>Vertebrates: digestive system</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Roman, F.</creatorcontrib><creatorcontrib>Pascaud, X.</creatorcontrib><creatorcontrib>Chomette, G.</creatorcontrib><creatorcontrib>Bueno, L.</creatorcontrib><creatorcontrib>Junien, J.L.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Gastroenterology (New York, N.Y. 1943)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Roman, F.</au><au>Pascaud, X.</au><au>Chomette, G.</au><au>Bueno, L.</au><au>Junien, J.L.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Autoradiographic localization of sigma opioid receptors in the gastrointestinal tract of the guinea pig</atitle><jtitle>Gastroenterology (New York, N.Y. 1943)</jtitle><addtitle>Gastroenterology</addtitle><date>1989-07-01</date><risdate>1989</risdate><volume>97</volume><issue>1</issue><spage>76</spage><epage>82</epage><pages>76-82</pages><issn>0016-5085</issn><eissn>1528-0012</eissn><coden>GASTAB</coden><abstract>The distribution of σ and phencyclidine binding sites in the gastrointestinal tract of the guinea pig was studied by autoradiography after in vitro incubation of tissue slices with (+)3H-SKF 10,047 and 3H-1-1-[(2-thienyl)cyclohexyl] piperidine to locate σ and phencyclidine receptors, respectively. A dense distribution of σ binding sites was observed in the mucosa and in the submucosal plexus, particularly at the level of the fundus and duodenum. Muscular layers were only marginally labeled. No phencyclidine binding site could be demonstrated in any area. This selective distribution suggests a functional role of σ receptors mainly in the control of endocrine or exocrine secretions, or both.</abstract><cop>New York, NY</cop><pub>Elsevier Inc</pub><pmid>2542120</pmid><doi>10.1016/0016-5085(89)91418-2</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
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| identifier | ISSN: 0016-5085 |
| ispartof | Gastroenterology (New York, N.Y. 1943), 1989-07, Vol.97 (1), p.76-82 |
| issn | 0016-5085 1528-0012 |
| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals; Alma/SFX Local Collection |
| subjects | Animals Autoradiography Biological and medical sciences Digestive System - analysis Fundamental and applied biological sciences. Psychology Guinea Pigs Intestinal Mucosa - analysis Male Phencyclidine - analysis Receptors, Neurotransmitter - analysis Receptors, Opioid - analysis Receptors, Phencyclidine Receptors, sigma Stomach Vertebrates: digestive system |
| title | Autoradiographic localization of sigma opioid receptors in the gastrointestinal tract of the guinea pig |
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