Decay characteristics of HIV-1-infected compartments during combination therapy

Analysis of changes in viral load after initiation of treatment with potent antiretroviral agents has provided substantial insight into the dynamics of human immunodeficiency virus type 1 (HIV-1). The concentration of HIV-1 in plasma drops by approximately 99% in the first two weeks of treatment owi...

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Veröffentlicht in:	Nature (London) 1997-05, Vol.387 (6629), p.188-191
Hauptverfasser:	Perelson, Alan S, Essunger, Paulina, Cao, Yunzhen, Vesanen, Mika, Hurley, Arlene, Saksela, Kalle, Markowitz, Martin, Ho, David D
Format:	Artikel
Sprache:	eng
Schlagworte:	AIDS/HIV Anti-HIV Agents - therapeutic use Antibiotics. Antiinfectious agents. Antiparasitic agents Antiretroviral agents Antiviral agents Biological and medical sciences CD4-Positive T-Lymphocytes - virology Decay Drug therapy Drug Therapy, Combination Half-Life HIV HIV Infections - drug therapy HIV Infections - virology HIV Protease Inhibitors - therapeutic use HIV-1 - physiology Human immunodeficiency virus human immunodeficiency virus 1 Humans Isoquinolines - therapeutic use Lamivudine - therapeutic use Leukocytes, Mononuclear - virology Lymphocytes Macrophages - virology Mathematics Medical research Medical sciences Models, Biological Nelfinavir Pharmacology. Drug treatments Proviruses - physiology Reverse Transcriptase Inhibitors - therapeutic use RNA, Viral - blood Sulfonic Acids - therapeutic use Viral Load Viremia Virus Latency Zidovudine - therapeutic use
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