Combination of osteoinductive bone proteins differentiates mesenchymal C3H/10T1/2 cells specifically to the cartilage lineage

During embryonic development, cartilage formation involves the condensation of mesenchymal stem cells and a series of maturation steps that ultimately results in the mineralized hypertrophic chondrocyte. The embryonic, murine, mesenchymal stem cell line, C3H/10T1/2, is pluripotent; exposure to azacy...

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Veröffentlicht in:	Journal of cellular biochemistry 1997-06, Vol.65 (3), p.325-339
Hauptverfasser:	Atkinson, Brent L., Fantle, Kelley S., Benedict, James J., Huffer, William E., Gutierrez-Hartmann, Arthur
Format:	Artikel
Sprache:	eng
Schlagworte:	Adipocytes - cytology ascorbic acid Blood bone morphogenetic protein Bone Morphogenetic Protein 2 Bone Morphogenetic Proteins - pharmacology Cartilage - cytology Cartilage - metabolism Cell Differentiation - drug effects Cell Line Cell Lineage defined media development Humans Immunohistochemistry in vitro Mesoderm - cytology Microscopy, Electron Minerals - metabolism Recombinant Proteins - pharmacology stem cell Stem Cells - cytology Transforming Growth Factor beta
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