Many human L1 elements are capable of retrotransposition

Using a selective screening strategy to enrich for active L1 elements, we isolated 13 full-length elements from a human genomic library. We tested these and two previously-isolated L1s (L1.3 and L1.4) for reverse transcriptase (RT) activity and the ability to retrotranspose in HeLa cells. Of the 13...

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Veröffentlicht in:	Nature genetics 1997-05, Vol.16 (1), p.37-43
Hauptverfasser:	Sassaman, Donna M., Dombroski, Beth A., Moran, John V., Kimberland, Michelle L., Naas, Thierry P., DeBerardinis, Ralph J., Gabriel, Abram, Swergold, Gary D., Kazazian, Haig H.
Format:	Artikel
Sprache:	eng
Schlagworte:	Agriculture Animal Genetics and Genomics Animals Biological and medical sciences Biomedical and Life Sciences Biomedicine Cancer Research Chromosome Mapping Chromosomes, Human Fundamental and applied biological sciences. Psychology Gene Frequency Gene Function Genic rearrangement. Recombination. Transposable element Genome, Human HeLa Cells Human Genetics Humans Mice Molecular and cellular biology Molecular genetics Molecular Sequence Data Repetitive Sequences, Nucleic Acid Retroelements - genetics RNA-Directed DNA Polymerase - genetics RNA-Directed DNA Polymerase - metabolism Sequence Analysis, DNA
Online-Zugang:	Volltext
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