Identification of an autoantibody against alpha-enolase in primary biliary cirrhosis

Background: Primary biliary cirrhosis is a chronic cholestatic liver disease in which autoreactive T cells may play an important role in the destruction of intrahepatic bile ducts. However, target antigens remain unknown. Alpha-enolase-derived peptide binds to human leukocyte antigen (HLA)-DR8, whic...

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Veröffentlicht in:	Journal of hepatology 1997-04, Vol.26 (4), p.845-851
Hauptverfasser:	Akisawa, Naoaki, Maeda, Takashi, Iwasaki, Shinji, Onishi, Saburo
Format:	Artikel
Sprache:	eng
Schlagworte:	Acute Disease Animals Anti-alpha-enolase antibody Antibody Specificity Autoantibodies - analysis Autoantibodies - immunology Autoimmune Diseases - immunology Chronic Disease Female Hepatitis - immunology Hepatitis, Viral, Human - immunology Humans Immunoblotting Isoenzymes - immunology Liver Cirrhosis, Biliary - immunology Liver Cirrhosis, Biliary - mortality Liver Cirrhosis, Biliary - physiopathology Male Middle Aged Mortality Phosphopyruvate Hydratase - immunology Primary biliary cirrhosis Pyruvate Dehydrogenase Complex - immunology Rabbits Reference Values
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