Inhibition of Coumarin 7-Hydroxylase Activity in Human Liver Microsomes

Nine organic solvents and 47 commonly used P450 substrates and inhibitors were examined for their effects on coumarin 7-hydroxylase (CYP2A6) activity in human liver microsomes. Of the nine organic solvents examined (final concentration 1%, v/v), only methanol did not inhibit the 7-hydroxylation of c...

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Veröffentlicht in:	Archives of biochemistry and biophysics 1997-05, Vol.341 (1), p.47-61
Hauptverfasser:	Draper, Alison J., Madan, Ajay, Parkinson, Andrew
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aryl Hydrocarbon Hydroxylases Child, Preschool Coumarins - metabolism CYP2A6, chemical inhibition of coumarin 7-hydroxylation Cytochrome P-450 CYP2A6 Cytochrome P-450 Enzyme Inhibitors Cytochrome P-450 Enzyme System - metabolism cytochrome P450, chemical inhibition Dioxanes - pharmacology Enzyme Inhibitors - chemistry Enzyme Inhibitors - pharmacology Female Furans - pharmacology Humans Hydroxylation - drug effects inhibition of human coumarin 7-hydroxylase Kinetics Male Microsomes, Liver - enzymology Middle Aged Mixed Function Oxygenases - antagonists & inhibitors Mixed Function Oxygenases - metabolism Solvents - pharmacology Umbelliferones - metabolism
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