Differential Contributions of BRCA1 and BRCA2 to Early-Onset Breast Cancer
Studies of large families many of whose members have cancer have led to the identification of two genes, BRCA1 and BRCA2, that, when mutated, predispose family members to breast cancer. 1 – 4 Members of such kindreds who are heterozygous carriers of a germ-line mutation have a high probability of br...
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| Veröffentlicht in: | The New England journal of medicine 1997-05, Vol.336 (20), p.1416-1422 |
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| container_title | The New England journal of medicine |
| container_volume | 336 |
| creator | Krainer, Michael Silva-Arrieta, Sandra FitzGerald, Michael G Shimada, Akira Ishioka, Chikashi Kanamaru, Ryunosuke MacDonald, Deborah J Unsal, Hilal Finkelstein, Dianne M Bowcock, Anne Isselbacher, Kurt J Haber, Daniel A |
| description | Studies of large families many of whose members have cancer have led to the identification of two genes,
BRCA1
and
BRCA2,
that, when mutated, predispose family members to breast cancer.
1
–
4
Members of such kindreds who are heterozygous carriers of a germ-line mutation have a high probability of breast cancer.
5
,
6
Families in which breast cancer is linked to a
BRCA1
mutation also have increased susceptibility to ovarian cancer,
1
and families in which the link is to a
BRCA2
mutation include cases of male breast cancer.
7
As in other syndromes involving a predisposition to cancer, familial cases of breast cancer . . . |
| doi_str_mv | 10.1056/NEJM199705153362003 |
| format | Article |
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BRCA1
and
BRCA2,
that, when mutated, predispose family members to breast cancer.
1
–
4
Members of such kindreds who are heterozygous carriers of a germ-line mutation have a high probability of breast cancer.
5
,
6
Families in which breast cancer is linked to a
BRCA1
mutation also have increased susceptibility to ovarian cancer,
1
and families in which the link is to a
BRCA2
mutation include cases of male breast cancer.
7
As in other syndromes involving a predisposition to cancer, familial cases of breast cancer . . .</description><identifier>ISSN: 0028-4793</identifier><identifier>EISSN: 1533-4406</identifier><identifier>DOI: 10.1056/NEJM199705153362003</identifier><identifier>PMID: 9145678</identifier><identifier>CODEN: NEJMAG</identifier><language>eng</language><publisher>Boston, MA: Massachusetts Medical Society</publisher><subject>Adult ; Age of Onset ; Biological and medical sciences ; BRCA2 Protein ; Breast cancer ; Breast Neoplasms - ethnology ; Breast Neoplasms - genetics ; DNA Mutational Analysis - methods ; Female ; Frameshift Mutation ; Genes ; Genes, BRCA1 ; Germ-Line Mutation ; Gynecology. Andrology. Obstetrics ; Heterozygote ; Humans ; Mammary gland diseases ; Medical sciences ; Mutation ; Neoplasm Proteins - genetics ; Prevalence ; Risk ; Transcription Factors - genetics ; Tumors ; Women</subject><ispartof>The New England journal of medicine, 1997-05, Vol.336 (20), p.1416-1422</ispartof><rights>Copyright © 1997 Massachusetts Medical Society. All rights reserved.</rights><rights>1997 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c516t-594f2663db10b4ee80341755f252b021f26bdadd341240341c57ef41f66cb56a3</citedby><cites>FETCH-LOGICAL-c516t-594f2663db10b4ee80341755f252b021f26bdadd341240341c57ef41f66cb56a3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.nejm.org/doi/pdf/10.1056/NEJM199705153362003$$EPDF$$P50$$Gmms$$H</linktopdf><linktohtml>$$Uhttps://www.nejm.org/doi/full/10.1056/NEJM199705153362003$$EHTML$$P50$$Gmms$$H</linktohtml><link.rule.ids>314,776,780,2746,2747,26080,27901,27902,52357,54039</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=2660294$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/9145678$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Krainer, Michael</creatorcontrib><creatorcontrib>Silva-Arrieta, Sandra</creatorcontrib><creatorcontrib>FitzGerald, Michael G</creatorcontrib><creatorcontrib>Shimada, Akira</creatorcontrib><creatorcontrib>Ishioka, Chikashi</creatorcontrib><creatorcontrib>Kanamaru, Ryunosuke</creatorcontrib><creatorcontrib>MacDonald, Deborah J</creatorcontrib><creatorcontrib>Unsal, Hilal</creatorcontrib><creatorcontrib>Finkelstein, Dianne M</creatorcontrib><creatorcontrib>Bowcock, Anne</creatorcontrib><creatorcontrib>Isselbacher, Kurt J</creatorcontrib><creatorcontrib>Haber, Daniel A</creatorcontrib><title>Differential Contributions of BRCA1 and BRCA2 to Early-Onset Breast Cancer</title><title>The New England journal of medicine</title><addtitle>N Engl J Med</addtitle><description>Studies of large families many of whose members have cancer have led to the identification of two genes,
BRCA1
and
BRCA2,
that, when mutated, predispose family members to breast cancer.
1
–
4
Members of such kindreds who are heterozygous carriers of a germ-line mutation have a high probability of breast cancer.
5
,
6
Families in which breast cancer is linked to a
BRCA1
mutation also have increased susceptibility to ovarian cancer,
1
and families in which the link is to a
BRCA2
mutation include cases of male breast cancer.
7
As in other syndromes involving a predisposition to cancer, familial cases of breast cancer . . .</description><subject>Adult</subject><subject>Age of Onset</subject><subject>Biological and medical sciences</subject><subject>BRCA2 Protein</subject><subject>Breast cancer</subject><subject>Breast Neoplasms - ethnology</subject><subject>Breast Neoplasms - genetics</subject><subject>DNA Mutational Analysis - methods</subject><subject>Female</subject><subject>Frameshift Mutation</subject><subject>Genes</subject><subject>Genes, BRCA1</subject><subject>Germ-Line Mutation</subject><subject>Gynecology. Andrology. Obstetrics</subject><subject>Heterozygote</subject><subject>Humans</subject><subject>Mammary gland diseases</subject><subject>Medical sciences</subject><subject>Mutation</subject><subject>Neoplasm Proteins - genetics</subject><subject>Prevalence</subject><subject>Risk</subject><subject>Transcription Factors - genetics</subject><subject>Tumors</subject><subject>Women</subject><issn>0028-4793</issn><issn>1533-4406</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1997</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BEC</sourceid><sourceid>BENPR</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNqFkU1LxDAQhoMoun78AhGKiBepZvLZHLWuX6wuiJ5L2ibQpU01aQ_-e7Pu4kFEc8kw7zMzzLwIHQI-B8zFxdP04RGUkpgDp1QQjOkGmizjlDEsNtEEY5KlTCq6g3ZDWOD4gKlttK2AcSGzCXq4bqw13rih0W2S927wTTkOTe9C0tvk6jm_hES7-isiydAnU-3bj3TughmSK290GJJcu8r4fbRldRvMwfrfQ68305f8Lp3Nb-_zy1lacRBDyhWzRAhal4BLZkyGKQPJuSWclJhAFMta13XMErbUKi6NZWCFqEouNN1Dp6u-b75_H00Yiq4JlWlb7Uw_hkJmSoLM2L8gCAxZnBrB4x_goh-9i0sUhFDFiQIZIbqCKt-H4I0t3nzTaf9RAC6WfhS_-BGrjtatx7Iz9XfN2oCon6x1HSrdWh9P2YRvLB4KE7Vc5WyFdV0onFl0fw79BAcvmlA</recordid><startdate>19970515</startdate><enddate>19970515</enddate><creator>Krainer, Michael</creator><creator>Silva-Arrieta, Sandra</creator><creator>FitzGerald, Michael G</creator><creator>Shimada, Akira</creator><creator>Ishioka, Chikashi</creator><creator>Kanamaru, Ryunosuke</creator><creator>MacDonald, Deborah J</creator><creator>Unsal, Hilal</creator><creator>Finkelstein, Dianne M</creator><creator>Bowcock, Anne</creator><creator>Isselbacher, Kurt J</creator><creator>Haber, Daniel A</creator><general>Massachusetts Medical Society</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>0TZ</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>8AO</scope><scope>8C1</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AN0</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BEC</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>HCIFZ</scope><scope>K0Y</scope><scope>LK8</scope><scope>M0R</scope><scope>M0T</scope><scope>M1P</scope><scope>M2M</scope><scope>M2O</scope><scope>M2P</scope><scope>M7P</scope><scope>MBDVC</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PSYQQ</scope><scope>Q9U</scope><scope>7TO</scope><scope>H94</scope><scope>7X8</scope></search><sort><creationdate>19970515</creationdate><title>Differential Contributions of BRCA1 and BRCA2 to Early-Onset Breast Cancer</title><author>Krainer, Michael ; Silva-Arrieta, Sandra ; FitzGerald, Michael G ; Shimada, Akira ; Ishioka, Chikashi ; Kanamaru, Ryunosuke ; MacDonald, Deborah J ; Unsal, Hilal ; Finkelstein, Dianne M ; Bowcock, Anne ; Isselbacher, Kurt J ; Haber, Daniel A</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c516t-594f2663db10b4ee80341755f252b021f26bdadd341240341c57ef41f66cb56a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1997</creationdate><topic>Adult</topic><topic>Age of Onset</topic><topic>Biological and medical sciences</topic><topic>BRCA2 Protein</topic><topic>Breast cancer</topic><topic>Breast Neoplasms - ethnology</topic><topic>Breast Neoplasms - genetics</topic><topic>DNA Mutational Analysis - methods</topic><topic>Female</topic><topic>Frameshift Mutation</topic><topic>Genes</topic><topic>Genes, BRCA1</topic><topic>Germ-Line Mutation</topic><topic>Gynecology. Andrology. Obstetrics</topic><topic>Heterozygote</topic><topic>Humans</topic><topic>Mammary gland diseases</topic><topic>Medical sciences</topic><topic>Mutation</topic><topic>Neoplasm Proteins - genetics</topic><topic>Prevalence</topic><topic>Risk</topic><topic>Transcription Factors - genetics</topic><topic>Tumors</topic><topic>Women</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Krainer, Michael</creatorcontrib><creatorcontrib>Silva-Arrieta, Sandra</creatorcontrib><creatorcontrib>FitzGerald, Michael G</creatorcontrib><creatorcontrib>Shimada, Akira</creatorcontrib><creatorcontrib>Ishioka, Chikashi</creatorcontrib><creatorcontrib>Kanamaru, Ryunosuke</creatorcontrib><creatorcontrib>MacDonald, Deborah J</creatorcontrib><creatorcontrib>Unsal, Hilal</creatorcontrib><creatorcontrib>Finkelstein, Dianne M</creatorcontrib><creatorcontrib>Bowcock, Anne</creatorcontrib><creatorcontrib>Isselbacher, Kurt J</creatorcontrib><creatorcontrib>Haber, Daniel A</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Pharma and Biotech Premium PRO</collection><collection>Nursing & Allied Health Database</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>British Nursing Database</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>eLibrary</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>SciTech Premium Collection</collection><collection>New England Journal of Medicine</collection><collection>ProQuest Biological Science Collection</collection><collection>Consumer Health Database</collection><collection>Healthcare Administration Database</collection><collection>Medical Database</collection><collection>ProQuest Psychology</collection><collection>Research Library</collection><collection>Science Database</collection><collection>Biological Science Database</collection><collection>Research Library (Corporate)</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest One Psychology</collection><collection>ProQuest Central Basic</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>The New England journal of medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Krainer, Michael</au><au>Silva-Arrieta, Sandra</au><au>FitzGerald, Michael G</au><au>Shimada, Akira</au><au>Ishioka, Chikashi</au><au>Kanamaru, Ryunosuke</au><au>MacDonald, Deborah J</au><au>Unsal, Hilal</au><au>Finkelstein, Dianne M</au><au>Bowcock, Anne</au><au>Isselbacher, Kurt J</au><au>Haber, Daniel A</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Differential Contributions of BRCA1 and BRCA2 to Early-Onset Breast Cancer</atitle><jtitle>The New England journal of medicine</jtitle><addtitle>N Engl J Med</addtitle><date>1997-05-15</date><risdate>1997</risdate><volume>336</volume><issue>20</issue><spage>1416</spage><epage>1422</epage><pages>1416-1422</pages><issn>0028-4793</issn><eissn>1533-4406</eissn><coden>NEJMAG</coden><abstract>Studies of large families many of whose members have cancer have led to the identification of two genes,
BRCA1
and
BRCA2,
that, when mutated, predispose family members to breast cancer.
1
–
4
Members of such kindreds who are heterozygous carriers of a germ-line mutation have a high probability of breast cancer.
5
,
6
Families in which breast cancer is linked to a
BRCA1
mutation also have increased susceptibility to ovarian cancer,
1
and families in which the link is to a
BRCA2
mutation include cases of male breast cancer.
7
As in other syndromes involving a predisposition to cancer, familial cases of breast cancer . . .</abstract><cop>Boston, MA</cop><pub>Massachusetts Medical Society</pub><pmid>9145678</pmid><doi>10.1056/NEJM199705153362003</doi><tpages>7</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0028-4793 |
| ispartof | The New England journal of medicine, 1997-05, Vol.336 (20), p.1416-1422 |
| issn | 0028-4793 1533-4406 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_78971784 |
| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; New England Journal of Medicine |
| subjects | Adult Age of Onset Biological and medical sciences BRCA2 Protein Breast cancer Breast Neoplasms - ethnology Breast Neoplasms - genetics DNA Mutational Analysis - methods Female Frameshift Mutation Genes Genes, BRCA1 Germ-Line Mutation Gynecology. Andrology. Obstetrics Heterozygote Humans Mammary gland diseases Medical sciences Mutation Neoplasm Proteins - genetics Prevalence Risk Transcription Factors - genetics Tumors Women |
| title | Differential Contributions of BRCA1 and BRCA2 to Early-Onset Breast Cancer |
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