An improved method for the measurement of lidocaine and its metabolites in rat plasma

An improved method is described for the quantitation of lidocaine and its dominant metabolites in rat plasma, 3-hydroxy-lidocaine glucuronide and 3-hydroxy-MEG-X glucuronide. Frozen plasma samples (100-200 microliters) were thawed and deproteinated by precipitation with acetonitrile, before the conv...

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Veröffentlicht in:	Therapeutic drug monitoring 1997-04, Vol.19 (2), p.179-184
Hauptverfasser:	ROSSI, S. S, MOORE, A. C, HAGEY, L. R, YAKSH, T. L, CHAPLAN, S. R
Format:	Artikel
Sprache:	eng
Schlagworte:	Analysis Animals Biological and medical sciences Chromatography, Thin Layer General pharmacology Lidocaine - blood Lidocaine - metabolism Male Medical sciences Pharmacology. Drug treatments Rats Rats, Sprague-Dawley
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