Effects of Thallium Ion on Cellular Components of the Skin
Thallium salts have been employed by dermatologists to cause depilation, and dermatologic features are prominent in thallium overdose. These features include alopecia and follicular hyperkeratosis. Administration of thallium to pregnant animals results in limb deformities, similar to those seen afte...
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| Veröffentlicht in: | Journal of dermatology 1997-03, Vol.24 (3), p.147-155 |
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| container_title | Journal of dermatology |
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| creator | Arbiser, Jack L. Alani, Rhoda Flynn, Evelyn Wooten, Virginia Byers, Hugh Randolph |
| description | Thallium salts have been employed by dermatologists to cause depilation, and dermatologic features are prominent in thallium overdose. These features include alopecia and follicular hyperkeratosis. Administration of thallium to pregnant animals results in limb deformities, similar to those seen after thalidomide embryopathy. These findings suggest that thallium may act on keratinocytes, melanocytes, and endothelial cells. We show that thallium exerts pleiotropic effects on proliferation, cell shape and motility of multiple cell types. These findings may help explain the clinical findings of thallotoxicosis. |
| doi_str_mv | 10.1111/j.1346-8138.1997.tb02762.x |
| format | Article |
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These features include alopecia and follicular hyperkeratosis. Administration of thallium to pregnant animals results in limb deformities, similar to those seen after thalidomide embryopathy. These findings suggest that thallium may act on keratinocytes, melanocytes, and endothelial cells. We show that thallium exerts pleiotropic effects on proliferation, cell shape and motility of multiple cell types. 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These findings may help explain the clinical findings of thallotoxicosis.</description><subject>Animals</subject><subject>Cell Division - drug effects</subject><subject>Cell Size - drug effects</subject><subject>endothelium</subject><subject>keratinocytes</subject><subject>Keratinocytes - metabolism</subject><subject>Lipid Peroxidation - drug effects</subject><subject>Male</subject><subject>melanoma</subject><subject>Melanoma, Experimental - pathology</subject><subject>Mice</subject><subject>Mice, Inbred Strains</subject><subject>Protein Precursors - metabolism</subject><subject>Skin - cytology</subject><subject>Skin - drug effects</subject><subject>Skin - metabolism</subject><subject>Skin - ultrastructure</subject><subject>thallium</subject><subject>Thallium - pharmacology</subject><subject>Tumor Cells, Cultured</subject><issn>0385-2407</issn><issn>1346-8138</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1997</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqVkMtOwzAQRS0EKqXwCUgRC3YJntix465AobxUiQVlbTmurabkUeJEtH9PQqLuGY00I907Dx2EbgAH0MXdNgBCmR8DiQMQggdNikPOwmB_gqZH6RRNMYkjP6SYn6ML57YYhyICPEETAUAZ4CmaL6w1unFeZb3VRuV51hbea1V6XSYmz9tc1V5SFbuqNOVgazbG-_jKykt0ZlXuzNVYZ-jzabFKXvzl-_Nr8rD0NYEo9I3mPFQgLAdLgXEiaIqJYkxjxSPBqE2jNXDDiNKwxkxhQS1NtVIYx6EgZIZuh727uvpujWtkkTnd_aZKU7VO8liwGDB0xvlg1HXlXG2s3NVZoeqDBCx7cHIrezqypyN7cHIEJ_fd8PV4pU0Lsz6OjqQ6_X7Qf7LcHP6xWb49Lv5a8gvtOHwn</recordid><startdate>199703</startdate><enddate>199703</enddate><creator>Arbiser, Jack L.</creator><creator>Alani, Rhoda</creator><creator>Flynn, Evelyn</creator><creator>Wooten, Virginia</creator><creator>Byers, Hugh Randolph</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>199703</creationdate><title>Effects of Thallium Ion on Cellular Components of the Skin</title><author>Arbiser, Jack L. ; Alani, Rhoda ; Flynn, Evelyn ; Wooten, Virginia ; Byers, Hugh Randolph</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3152-ec772a19f71f4167394b03a66c0a75964fb5d17e63ac1d06a094f4bcaa0082933</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1997</creationdate><topic>Animals</topic><topic>Cell Division - drug effects</topic><topic>Cell Size - drug effects</topic><topic>endothelium</topic><topic>keratinocytes</topic><topic>Keratinocytes - metabolism</topic><topic>Lipid Peroxidation - drug effects</topic><topic>Male</topic><topic>melanoma</topic><topic>Melanoma, Experimental - pathology</topic><topic>Mice</topic><topic>Mice, Inbred Strains</topic><topic>Protein Precursors - metabolism</topic><topic>Skin - cytology</topic><topic>Skin - drug effects</topic><topic>Skin - metabolism</topic><topic>Skin - ultrastructure</topic><topic>thallium</topic><topic>Thallium - pharmacology</topic><topic>Tumor Cells, Cultured</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Arbiser, Jack L.</creatorcontrib><creatorcontrib>Alani, Rhoda</creatorcontrib><creatorcontrib>Flynn, Evelyn</creatorcontrib><creatorcontrib>Wooten, Virginia</creatorcontrib><creatorcontrib>Byers, Hugh Randolph</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of dermatology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Arbiser, Jack L.</au><au>Alani, Rhoda</au><au>Flynn, Evelyn</au><au>Wooten, Virginia</au><au>Byers, Hugh Randolph</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effects of Thallium Ion on Cellular Components of the Skin</atitle><jtitle>Journal of dermatology</jtitle><addtitle>J Dermatol</addtitle><date>1997-03</date><risdate>1997</risdate><volume>24</volume><issue>3</issue><spage>147</spage><epage>155</epage><pages>147-155</pages><issn>0385-2407</issn><eissn>1346-8138</eissn><abstract>Thallium salts have been employed by dermatologists to cause depilation, and dermatologic features are prominent in thallium overdose. These features include alopecia and follicular hyperkeratosis. Administration of thallium to pregnant animals results in limb deformities, similar to those seen after thalidomide embryopathy. These findings suggest that thallium may act on keratinocytes, melanocytes, and endothelial cells. We show that thallium exerts pleiotropic effects on proliferation, cell shape and motility of multiple cell types. These findings may help explain the clinical findings of thallotoxicosis.</abstract><cop>England</cop><pmid>9114610</pmid><doi>10.1111/j.1346-8138.1997.tb02762.x</doi><tpages>9</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0385-2407 |
| ispartof | Journal of dermatology, 1997-03, Vol.24 (3), p.147-155 |
| issn | 0385-2407 1346-8138 |
| language | eng |
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| source | MEDLINE; Wiley Online Library |
| subjects | Animals Cell Division - drug effects Cell Size - drug effects endothelium keratinocytes Keratinocytes - metabolism Lipid Peroxidation - drug effects Male melanoma Melanoma, Experimental - pathology Mice Mice, Inbred Strains Protein Precursors - metabolism Skin - cytology Skin - drug effects Skin - metabolism Skin - ultrastructure thallium Thallium - pharmacology Tumor Cells, Cultured |
| title | Effects of Thallium Ion on Cellular Components of the Skin |
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