Deltorphin, a novel amphibian skin peptide with high selectivity and affinity for δ opioid receptors

With a cDNA library prepared from skin of Phyllomedusa sauvagei, the sequence of the precursor of dermorphin was elucidated recently. The sequence suggested the existence of another peptide, distantly related to dermorphin. Two variants of this peptide have now been synthesized containing either L-...

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Veröffentlicht in:	European journal of pharmacology 1989-03, Vol.162 (1), p.123-128
Hauptverfasser:	Kreil, Gunther, Barra, Donatella, Simmaco, Maurizio, Erspamer, Vittorio, Falconieri Erspamer, Giuliana, Negri, Lucia, Severini, Cinzia, Corsi, Rita, Melchiorri, Pietro
Format:	Artikel
Sprache:	eng
Schlagworte:	Aminoacids, peptides. Hormones. Neuropeptides Analytical, structural and metabolic biochemistry Animals Anura Biological and medical sciences Chromatography, High Pressure Liquid Deltorphin Fundamental and applied biological sciences. Psychology Guinea Pigs Ileum - drug effects In Vitro Techniques Isolation, Sequencing Mice Muscle Contraction - drug effects Muscle, Smooth - drug effects Narcotics - pharmacology Oligopeptides - metabolism Proteins Rats Receptors, Opioid - metabolism Receptors, Opioid, delta Skin Physiological Phenomena Tissue Extracts - analysis Tissue Extracts - pharmacology δ Opioid receptor agonists
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