Intact Mirror-Tracing and Impaired Rotary-Pursuit Skill Learning in Patients With Huntington's Disease: Evidence for Dissociable Memory Systems in Skill Learning
Skill learning in early-stage Huntington's disease (HD) patients was compared with that of normal controls on 2 perceptual-motor tasks, rotary pursuit and mirror tracing. HD patients demonstrated a dissociation between impaired rotary-pursuit and intact mirror-tracing skill learning. These resu...
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| Veröffentlicht in: | Neuropsychology 1997-04, Vol.11 (2), p.272-281 |
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| creator | Gabrieli, John D. E Stebbins, Glenn T Singh, Jaswinder Willingham, Daniel B Goetz, Christopher G |
| description | Skill learning in early-stage Huntington's disease (HD) patients was compared with that of normal controls on 2 perceptual-motor tasks, rotary pursuit and mirror tracing. HD patients demonstrated a dissociation between impaired rotary-pursuit and intact mirror-tracing skill learning. These results suggest that different forms of perceptual-motor skill learning are mediated by separable neural circuits. A striatal memory system may be essential for sequence or open-loop skill learning but not for skills that involve the closed-loop learning of novel visual-response mappings. It is hypothesized that working memory deficits in HD resulting from frontostriatal damage may account broadly for intact and impaired long-term learning and memory in HD patients. |
| doi_str_mv | 10.1037/0894-4105.11.2.272 |
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| ispartof | Neuropsychology, 1997-04, Vol.11 (2), p.272-281 |
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| language | eng |
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| source | APA PsycARTICLES; MEDLINE |
| subjects | Adult Aged Dissociative Disorders - psychology Female Human Humans Huntington Disease - psychology Huntingtons Disease Learning - physiology Male Memory Memory - physiology Middle Aged Perceptual Motor Learning Rotary Pursuit Task Performance and Analysis |
| title | Intact Mirror-Tracing and Impaired Rotary-Pursuit Skill Learning in Patients With Huntington's Disease: Evidence for Dissociable Memory Systems in Skill Learning |
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