The DCC Protein and Colon Cancer
To the Editor: In their study of immunohistochemical staining of the DCC protein and its association with the prognosis of colorectal cancer (Dec. 5 issue), 1 Shibata et al. report that the absence of stainable DCC is predictive of mortality. Absence of evidence, however, is not evidence of absence....
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| Veröffentlicht in: | The New England journal of medicine 1997-05, Vol.336 (20), p.1456-1457 |
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| container_title | The New England journal of medicine |
| container_volume | 336 |
| creator | Ghnassia, J P |
| description | To the Editor:
In their study of immunohistochemical staining of the DCC protein and its association with the prognosis of colorectal cancer (Dec. 5 issue),
1
Shibata et al. report that the absence of stainable DCC is predictive of mortality. Absence of evidence, however, is not evidence of absence. The authors used tissues that were paraffin-embedded, a method of preparation that may extract stainable moieties from cells and thus result in false negative results. Inasmuch as the authors found it necessary to employ a harsh protocol, involving microwaving cells under pressure, to enhance the performance of their staining procedure, one wonders . . . |
| doi_str_mv | 10.1056/NEJM199705153362015 |
| format | Article |
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In their study of immunohistochemical staining of the DCC protein and its association with the prognosis of colorectal cancer (Dec. 5 issue),
1
Shibata et al. report that the absence of stainable DCC is predictive of mortality. Absence of evidence, however, is not evidence of absence. The authors used tissues that were paraffin-embedded, a method of preparation that may extract stainable moieties from cells and thus result in false negative results. Inasmuch as the authors found it necessary to employ a harsh protocol, involving microwaving cells under pressure, to enhance the performance of their staining procedure, one wonders . . .</description><identifier>ISSN: 0028-4793</identifier><identifier>EISSN: 1533-4406</identifier><identifier>DOI: 10.1056/NEJM199705153362015</identifier><identifier>PMID: 9148153</identifier><language>eng</language><publisher>United States: Massachusetts Medical Society</publisher><subject>Biomarkers, Tumor - analysis ; Cell Adhesion Molecules - analysis ; Colorectal Neoplasms - chemistry ; Colorectal Neoplasms - pathology ; DCC Receptor ; Humans ; Neoplasm Staging ; Receptors, Cell Surface ; Tumor Suppressor Proteins</subject><ispartof>The New England journal of medicine, 1997-05, Vol.336 (20), p.1456-1457</ispartof><rights>Copyright © 1997 Massachusetts Medical Society. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c437t-dd49ae9cf65a3758d8b127bfc9d337b65b80a2637c4b009bfafa1bc6110c3ae83</citedby><cites>FETCH-LOGICAL-c437t-dd49ae9cf65a3758d8b127bfc9d337b65b80a2637c4b009bfafa1bc6110c3ae83</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.nejm.org/doi/pdf/10.1056/NEJM199705153362015$$EPDF$$P50$$Gmms$$H</linktopdf><linktohtml>$$Uhttps://www.nejm.org/doi/full/10.1056/NEJM199705153362015$$EHTML$$P50$$Gmms$$H</linktohtml><link.rule.ids>314,776,780,2745,2746,26082,27903,27904,52361,54043,64364</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/9148153$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ghnassia, J P</creatorcontrib><title>The DCC Protein and Colon Cancer</title><title>The New England journal of medicine</title><addtitle>N Engl J Med</addtitle><description>To the Editor:
In their study of immunohistochemical staining of the DCC protein and its association with the prognosis of colorectal cancer (Dec. 5 issue),
1
Shibata et al. report that the absence of stainable DCC is predictive of mortality. Absence of evidence, however, is not evidence of absence. The authors used tissues that were paraffin-embedded, a method of preparation that may extract stainable moieties from cells and thus result in false negative results. Inasmuch as the authors found it necessary to employ a harsh protocol, involving microwaving cells under pressure, to enhance the performance of their staining procedure, one wonders . . .</description><subject>Biomarkers, Tumor - analysis</subject><subject>Cell Adhesion Molecules - analysis</subject><subject>Colorectal Neoplasms - chemistry</subject><subject>Colorectal Neoplasms - pathology</subject><subject>DCC Receptor</subject><subject>Humans</subject><subject>Neoplasm Staging</subject><subject>Receptors, Cell Surface</subject><subject>Tumor Suppressor Proteins</subject><issn>0028-4793</issn><issn>1533-4406</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1997</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkMtOwzAQRS0EKqXwBQgpKzYoMI7fSxTKS-WxKGvLdhzRKo9ipwv-nlSJWCHU2cxI98xZXITOMVxjYPzmdf78gpUSwDAjhGeA2QGa7u6UUuCHaAqQyZQKRY7RSYxr6AdTNUEThanswSlKlp8-ucvz5D20nV81iWmKJG-rtkly0zgfTtFRaaroz8Y9Qx_382X-mC7eHp7y20XqKBFdWhRUGa9cyZkhgslCWpwJWzpVECIsZ1aCyTgRjloAZUtTGmwdxxgcMV6SGbocvJvQfm197HS9is5XlWl8u41aSMUp7g17gESpDPYCJVOiB8kAutDGGHypN2FVm_CtMehd0_qPpvuvi1G_tbUvfn_Gavv8asjrOurGr-t_bT_DsoIe</recordid><startdate>19970515</startdate><enddate>19970515</enddate><creator>Ghnassia, J P</creator><general>Massachusetts Medical Society</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19970515</creationdate><title>The DCC Protein and Colon Cancer</title><author>Ghnassia, J P</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c437t-dd49ae9cf65a3758d8b127bfc9d337b65b80a2637c4b009bfafa1bc6110c3ae83</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1997</creationdate><topic>Biomarkers, Tumor - analysis</topic><topic>Cell Adhesion Molecules - analysis</topic><topic>Colorectal Neoplasms - chemistry</topic><topic>Colorectal Neoplasms - pathology</topic><topic>DCC Receptor</topic><topic>Humans</topic><topic>Neoplasm Staging</topic><topic>Receptors, Cell Surface</topic><topic>Tumor Suppressor Proteins</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ghnassia, J P</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>The New England journal of medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ghnassia, J P</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The DCC Protein and Colon Cancer</atitle><jtitle>The New England journal of medicine</jtitle><addtitle>N Engl J Med</addtitle><date>1997-05-15</date><risdate>1997</risdate><volume>336</volume><issue>20</issue><spage>1456</spage><epage>1457</epage><pages>1456-1457</pages><issn>0028-4793</issn><eissn>1533-4406</eissn><abstract>To the Editor:
In their study of immunohistochemical staining of the DCC protein and its association with the prognosis of colorectal cancer (Dec. 5 issue),
1
Shibata et al. report that the absence of stainable DCC is predictive of mortality. Absence of evidence, however, is not evidence of absence. The authors used tissues that were paraffin-embedded, a method of preparation that may extract stainable moieties from cells and thus result in false negative results. Inasmuch as the authors found it necessary to employ a harsh protocol, involving microwaving cells under pressure, to enhance the performance of their staining procedure, one wonders . . .</abstract><cop>United States</cop><pub>Massachusetts Medical Society</pub><pmid>9148153</pmid><doi>10.1056/NEJM199705153362015</doi><tpages>2</tpages></addata></record> |
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| ispartof | The New England journal of medicine, 1997-05, Vol.336 (20), p.1456-1457 |
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| language | eng |
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| source | MEDLINE; EZB-FREE-00999 freely available EZB journals; ProQuest Central UK/Ireland; New England Journal of Medicine |
| subjects | Biomarkers, Tumor - analysis Cell Adhesion Molecules - analysis Colorectal Neoplasms - chemistry Colorectal Neoplasms - pathology DCC Receptor Humans Neoplasm Staging Receptors, Cell Surface Tumor Suppressor Proteins |
| title | The DCC Protein and Colon Cancer |
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