Neuronal release of soluble nucleotidases and their role in neurotransmitter inactivation

Efficient control of synaptic transmission requires a rapid mechanism for terminating the actions of neurotransmitters. For amino acids and monoamines, this is achieved by their uptake into the cell by specific high-affinity transporters 1 ; acetylcholine is first broken down in the extracellular sp...

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Veröffentlicht in:	Nature (London) 1997-05, Vol.387 (6628), p.76-79
Hauptverfasser:	Todorov, Latchezar D., Mihaylova-Todorova, Svetlana, Westfall, Timothy D., Sneddon, Peter, Kennedy, Charles, Bjur, Richard A., Westfall, David P.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenosine Triphosphate - analogs & derivatives Adenosine Triphosphate - metabolism Adenosine Triphosphate - pharmacology Amino acids Animals ATP Biochemistry Biological and medical sciences Biology Calcium - metabolism Chromatography, High Pressure Liquid Enzyme Inhibitors - pharmacology Ethenoadenosine Triphosphate - metabolism Fundamental and applied biological sciences. Psychology Guinea Pigs Humanities and Social Sciences In Vitro Techniques Inactivation letter Male multidisciplinary Neurons - metabolism Neurotransmitter Agents - antagonists & inhibitors Neurotransmitter Agents - metabolism Norepinephrine - metabolism Nucleotidases - antagonists & inhibitors Nucleotidases - metabolism Peripheral nervous system. Autonomic nervous system. Neuromuscular transmission. Ganglionic transmission. Electric organ Science Science (multidisciplinary) Solubility Sympathetic Nervous System - cytology Sympathetic Nervous System - metabolism Vas Deferens - innervation Vas Deferens - metabolism Vertebrates: nervous system and sense organs
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