Abnormal glucose transport and GLUT1 cell-surface content in fibroblasts and skeletal muscle from NIDDM and obese subjects

Glucose transport and GLUT1 expression were studied in fibroblasts from 7 lean and 5 obese non-insulin-dependent diabetic (NIDDM) subjects with at least 2 NIDDM first-degree relatives and from 12 lean and 5 obese non-diabetic subjects with no family history of diabetes. The obese individuals also ha...

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Veröffentlicht in:	Diabetologia 1997-04, Vol.40 (4), p.421-429
Hauptverfasser:	MIELE, C, FORMISANO, P, CONDORELLI, G, CARUSO, M, ORIENTE, F, ANDREOZZI, F, TOCCHETTI, C. G, RICCARDI, G, BEGUINOT, F
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Biological and medical sciences Biological Transport Blood Glucose - metabolism Cell Membrane - metabolism Cells, Cultured Deoxyglucose - metabolism Diabetes Mellitus - genetics Diabetes Mellitus - metabolism Diabetes Mellitus, Type 2 - metabolism Diabetes. Impaired glucose tolerance Endocrine pancreas. Apud cells (diseases) Endocrinopathies Etiopathogenesis. Screening. Investigations. Target tissue resistance Female Fibroblasts - metabolism Glucose - metabolism Glucose Transporter Type 1 Hexokinase - metabolism Humans Insulin - blood Kinetics Male Medical sciences Microsomes - metabolism Middle Aged Monosaccharide Transport Proteins - biosynthesis Monosaccharide Transport Proteins - metabolism Muscle, Skeletal - metabolism Obesity - metabolism Receptor, Insulin - metabolism Reference Values Regression Analysis RNA, Messenger - biosynthesis Skin - metabolism Thinness - metabolism Transcription, Genetic
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