Nicotine and D-cycloserine enhance acquisition of water maze spatial navigation in aged rats
WE investigated the effect of nicotine, a nicotinic agonist, and D-cycloserine (DCS, a partial glycine-B agonist of the N-methyl-D-aspartate (NMDA) receptor complex) on aging-induced defects of water maze (WM) spatial navigation in rats. Nicotine (0.3 mg kg, s.c.) or DCS (10 mg kg, i.p.) enhanced ac...
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| Veröffentlicht in: | Neuroreport 1997-02, Vol.8 (3), p.699-703 |
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| creator | Riekkinen, Minna Riekkinen, Paavo |
| description | WE investigated the effect of nicotine, a nicotinic agonist, and D-cycloserine (DCS, a partial glycine-B agonist of the N-methyl-D-aspartate (NMDA) receptor complex) on aging-induced defects of water maze (WM) spatial navigation in rats. Nicotine (0.3 mg kg, s.c.) or DCS (10 mg kg, i.p.) enhanced acquisition of the WM task. A combination of subthreshold doses of nicotine (0.1 mg kg) and DCS (3 mg kg) improved WM acquisition. A subthreshold dose of a competitive NMDA antagonist, CPP (1 mg kg), blocked the effect of nicotine (0.3 mg kg) on WM acquisition. A nicotine antagonist, mecamylamine (10 mg kg), impaired WM acquisition and had no effect on retention, but did not block the effect of DCS 10 mg kg. The results suggest that nicotine and DCS synergistically enhance spatial navigation in aged rats. |
| doi_str_mv | 10.1097/00001756-199702100-00024 |
| format | Article |
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Nicotine (0.3 mg kg, s.c.) or DCS (10 mg kg, i.p.) enhanced acquisition of the WM task. A combination of subthreshold doses of nicotine (0.1 mg kg) and DCS (3 mg kg) improved WM acquisition. A subthreshold dose of a competitive NMDA antagonist, CPP (1 mg kg), blocked the effect of nicotine (0.3 mg kg) on WM acquisition. A nicotine antagonist, mecamylamine (10 mg kg), impaired WM acquisition and had no effect on retention, but did not block the effect of DCS 10 mg kg. The results suggest that nicotine and DCS synergistically enhance spatial navigation in aged rats.</description><identifier>ISSN: 0959-4965</identifier><identifier>EISSN: 1473-558X</identifier><identifier>DOI: 10.1097/00001756-199702100-00024</identifier><identifier>PMID: 9106750</identifier><language>eng</language><publisher>Hagerstown, MD: Lippincott-Raven Publishers</publisher><subject>Aging - physiology ; Analysis of Variance ; Animals ; Behavioral psychophysiology ; Biological and medical sciences ; Cycloserine - pharmacology ; Excitatory Amino Acid Antagonists - pharmacology ; Fundamental and applied biological sciences. Psychology ; Male ; Maze Learning - drug effects ; Mecamylamine - pharmacology ; Neurotransmission and behavior ; Nicotine - pharmacology ; Piperazines - pharmacology ; Psychology. Psychoanalysis. Psychiatry ; Psychology. 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Nicotine (0.3 mg kg, s.c.) or DCS (10 mg kg, i.p.) enhanced acquisition of the WM task. A combination of subthreshold doses of nicotine (0.1 mg kg) and DCS (3 mg kg) improved WM acquisition. A subthreshold dose of a competitive NMDA antagonist, CPP (1 mg kg), blocked the effect of nicotine (0.3 mg kg) on WM acquisition. A nicotine antagonist, mecamylamine (10 mg kg), impaired WM acquisition and had no effect on retention, but did not block the effect of DCS 10 mg kg. The results suggest that nicotine and DCS synergistically enhance spatial navigation in aged rats.</description><subject>Aging - physiology</subject><subject>Analysis of Variance</subject><subject>Animals</subject><subject>Behavioral psychophysiology</subject><subject>Biological and medical sciences</subject><subject>Cycloserine - pharmacology</subject><subject>Excitatory Amino Acid Antagonists - pharmacology</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Male</subject><subject>Maze Learning - drug effects</subject><subject>Mecamylamine - pharmacology</subject><subject>Neurotransmission and behavior</subject><subject>Nicotine - pharmacology</subject><subject>Piperazines - pharmacology</subject><subject>Psychology. Psychoanalysis. Psychiatry</subject><subject>Psychology. 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Psychology</topic><topic>Male</topic><topic>Maze Learning - drug effects</topic><topic>Mecamylamine - pharmacology</topic><topic>Neurotransmission and behavior</topic><topic>Nicotine - pharmacology</topic><topic>Piperazines - pharmacology</topic><topic>Psychology. Psychoanalysis. Psychiatry</topic><topic>Psychology. Psychophysiology</topic><topic>Rats</topic><topic>Rats, Wistar</topic><topic>Receptors, N-Methyl-D-Aspartate - agonists</topic><topic>Reference Values</topic><topic>Space Perception</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Riekkinen, Minna</creatorcontrib><creatorcontrib>Riekkinen, Paavo</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Animal Behavior Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Neuroreport</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Riekkinen, Minna</au><au>Riekkinen, Paavo</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Nicotine and D-cycloserine enhance acquisition of water maze spatial navigation in aged rats</atitle><jtitle>Neuroreport</jtitle><addtitle>Neuroreport</addtitle><date>1997-02-10</date><risdate>1997</risdate><volume>8</volume><issue>3</issue><spage>699</spage><epage>703</epage><pages>699-703</pages><issn>0959-4965</issn><eissn>1473-558X</eissn><abstract>WE investigated the effect of nicotine, a nicotinic agonist, and D-cycloserine (DCS, a partial glycine-B agonist of the N-methyl-D-aspartate (NMDA) receptor complex) on aging-induced defects of water maze (WM) spatial navigation in rats. Nicotine (0.3 mg kg, s.c.) or DCS (10 mg kg, i.p.) enhanced acquisition of the WM task. A combination of subthreshold doses of nicotine (0.1 mg kg) and DCS (3 mg kg) improved WM acquisition. A subthreshold dose of a competitive NMDA antagonist, CPP (1 mg kg), blocked the effect of nicotine (0.3 mg kg) on WM acquisition. A nicotine antagonist, mecamylamine (10 mg kg), impaired WM acquisition and had no effect on retention, but did not block the effect of DCS 10 mg kg. The results suggest that nicotine and DCS synergistically enhance spatial navigation in aged rats.</abstract><cop>Hagerstown, MD</cop><pub>Lippincott-Raven Publishers</pub><pmid>9106750</pmid><doi>10.1097/00001756-199702100-00024</doi><tpages>5</tpages></addata></record> |
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| ispartof | Neuroreport, 1997-02, Vol.8 (3), p.699-703 |
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| subjects | Aging - physiology Analysis of Variance Animals Behavioral psychophysiology Biological and medical sciences Cycloserine - pharmacology Excitatory Amino Acid Antagonists - pharmacology Fundamental and applied biological sciences. Psychology Male Maze Learning - drug effects Mecamylamine - pharmacology Neurotransmission and behavior Nicotine - pharmacology Piperazines - pharmacology Psychology. Psychoanalysis. Psychiatry Psychology. Psychophysiology Rats Rats, Wistar Receptors, N-Methyl-D-Aspartate - agonists Reference Values Space Perception |
| title | Nicotine and D-cycloserine enhance acquisition of water maze spatial navigation in aged rats |
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