The effect of intraocular 6-hydroxydopamine on retinal processing of primates
In previous studies, we showed that in the monkey, systemically administered N‐methyl, 4‐phenyl, 1‐2‐3‐6 tetrahydropyridine (MPTP) produces a chronic parkinsonian syndrome accompanied by spatial frequency‐dependent abnormalities in both the pattern electroretinogram and visual evoked potential. We d...
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| Veröffentlicht in: | Annals of neurology 1989-04, Vol.25 (4), p.357-364 |
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| container_title | Annals of neurology |
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| creator | Ghilardi, Maria Felice Marx, Marcia S. Bodis-Wollner, Ivan Camras, Carl B. Glover, Andrew A. |
| description | In previous studies, we showed that in the monkey, systemically administered N‐methyl, 4‐phenyl, 1‐2‐3‐6 tetrahydropyridine (MPTP) produces a chronic parkinsonian syndrome accompanied by spatial frequency‐dependent abnormalities in both the pattern electroretinogram and visual evoked potential. We describe the effect of intravitreally administered 6‐hydroxydopamine (6‐OH‐DA) on the pattern electroretinogram and pattern visual evoked potential of 3 aphakic monkeys. Because of the aphake condition, several complexities of intravitreal injection of 6‐OH‐DA could be avoided. Nevertheless, following 6‐OH‐DA treatment, both the phase and the amplitude of pattern electroretinogram and pattern visual evoked potential became abnormal. This abnormality was most pronounced for the higher spatial frequencies (2.5 and 3.5 cycles per degree), whereas lower spatial frequencies (0.5 and 1.2 cycles per degree) were less impaired. The effects of systemically administered MPTP on pattern electroretinogram and pattern visual evoked potential are similar to the effects of intravitreal injections of 6‐OH‐DA, suggesting that a retinal catecholaminergic system plays an important role in pattern vision of primates. |
| doi_str_mv | 10.1002/ana.410250407 |
| format | Article |
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We describe the effect of intravitreally administered 6‐hydroxydopamine (6‐OH‐DA) on the pattern electroretinogram and pattern visual evoked potential of 3 aphakic monkeys. Because of the aphake condition, several complexities of intravitreal injection of 6‐OH‐DA could be avoided. Nevertheless, following 6‐OH‐DA treatment, both the phase and the amplitude of pattern electroretinogram and pattern visual evoked potential became abnormal. This abnormality was most pronounced for the higher spatial frequencies (2.5 and 3.5 cycles per degree), whereas lower spatial frequencies (0.5 and 1.2 cycles per degree) were less impaired. The effects of systemically administered MPTP on pattern electroretinogram and pattern visual evoked potential are similar to the effects of intravitreal injections of 6‐OH‐DA, suggesting that a retinal catecholaminergic system plays an important role in pattern vision of primates.</description><identifier>ISSN: 0364-5134</identifier><identifier>EISSN: 1531-8249</identifier><identifier>DOI: 10.1002/ana.410250407</identifier><identifier>PMID: 2496639</identifier><identifier>CODEN: ANNED3</identifier><language>eng</language><publisher>Hoboken: Wiley Subscription Services, Inc., A Wiley Company</publisher><subject>Animals ; Biological and medical sciences ; Catecholaminergic system ; Electroretinography ; Evoked Potentials, Visual ; Female ; Hydroxydopamines - pharmacology ; Injections ; Macaca fascicularis ; Medical sciences ; Neuropharmacology ; Neurotransmitters. Neurotransmission. Receptors ; Oxidopamine ; Pharmacology. Drug treatments ; Retina - drug effects ; Retina - physiology ; Vitreous Body</subject><ispartof>Annals of neurology, 1989-04, Vol.25 (4), p.357-364</ispartof><rights>Copyright © 1989 The American Neurological Association</rights><rights>1989 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4037-61ba3eaeceab830ac7212da192ba7ae9ef1ad73a2851d0d943f61c74245f70863</citedby><cites>FETCH-LOGICAL-c4037-61ba3eaeceab830ac7212da192ba7ae9ef1ad73a2851d0d943f61c74245f70863</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fana.410250407$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fana.410250407$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=7323729$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/2496639$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ghilardi, Maria Felice</creatorcontrib><creatorcontrib>Marx, Marcia S.</creatorcontrib><creatorcontrib>Bodis-Wollner, Ivan</creatorcontrib><creatorcontrib>Camras, Carl B.</creatorcontrib><creatorcontrib>Glover, Andrew A.</creatorcontrib><title>The effect of intraocular 6-hydroxydopamine on retinal processing of primates</title><title>Annals of neurology</title><addtitle>Ann Neurol</addtitle><description>In previous studies, we showed that in the monkey, systemically administered N‐methyl, 4‐phenyl, 1‐2‐3‐6 tetrahydropyridine (MPTP) produces a chronic parkinsonian syndrome accompanied by spatial frequency‐dependent abnormalities in both the pattern electroretinogram and visual evoked potential. We describe the effect of intravitreally administered 6‐hydroxydopamine (6‐OH‐DA) on the pattern electroretinogram and pattern visual evoked potential of 3 aphakic monkeys. Because of the aphake condition, several complexities of intravitreal injection of 6‐OH‐DA could be avoided. Nevertheless, following 6‐OH‐DA treatment, both the phase and the amplitude of pattern electroretinogram and pattern visual evoked potential became abnormal. This abnormality was most pronounced for the higher spatial frequencies (2.5 and 3.5 cycles per degree), whereas lower spatial frequencies (0.5 and 1.2 cycles per degree) were less impaired. The effects of systemically administered MPTP on pattern electroretinogram and pattern visual evoked potential are similar to the effects of intravitreal injections of 6‐OH‐DA, suggesting that a retinal catecholaminergic system plays an important role in pattern vision of primates.</description><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Catecholaminergic system</subject><subject>Electroretinography</subject><subject>Evoked Potentials, Visual</subject><subject>Female</subject><subject>Hydroxydopamines - pharmacology</subject><subject>Injections</subject><subject>Macaca fascicularis</subject><subject>Medical sciences</subject><subject>Neuropharmacology</subject><subject>Neurotransmitters. Neurotransmission. Receptors</subject><subject>Oxidopamine</subject><subject>Pharmacology. Drug treatments</subject><subject>Retina - drug effects</subject><subject>Retina - physiology</subject><subject>Vitreous Body</subject><issn>0364-5134</issn><issn>1531-8249</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1989</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kM1v00AQxVeoKKSFY4-VfKi4Ocx-eNc-RlVJi0r5UIDjarKepQuOne46avPf4xAr4sRpDu_33jw9xs45zDiAeIctzhQHUYAC84JNeSF5XgpVnbApSK3ygkv1ip2m9AsAKs1hwiaDrLWspuzj8oEy8p5cn3U-C20fsXPbBmOm84ddHbvnXd1tcB1ayro2i9SHFptsEztHKYX25962iWGNPaXX7KXHJtGb8Z6xb--vl1c3-d2nxe3V_C53CqTJNV-hJCRHuColoDOCixp5JVZokCryHGsjUZQFr6GulPSaO6OEKryBUssz9vaQO9R43FLq7TokR02DLXXbZE1ZaVClGMD8ALrYpRTJ279V485ysPv57DCfPc438Bdj8Ha1pvpIj3sN-uWoY3LY-IitC-mIGSmkEXvMHLCn0NDu_z_t_H7-b4GxcEg9PR-dGH9bbaQp7I_7hf0uvhTm6_Kz_SD_ANExl1g</recordid><startdate>198904</startdate><enddate>198904</enddate><creator>Ghilardi, Maria Felice</creator><creator>Marx, Marcia S.</creator><creator>Bodis-Wollner, Ivan</creator><creator>Camras, Carl B.</creator><creator>Glover, Andrew A.</creator><general>Wiley Subscription Services, Inc., A Wiley Company</general><general>Willey-Liss</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>198904</creationdate><title>The effect of intraocular 6-hydroxydopamine on retinal processing of primates</title><author>Ghilardi, Maria Felice ; Marx, Marcia S. ; Bodis-Wollner, Ivan ; Camras, Carl B. ; Glover, Andrew A.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4037-61ba3eaeceab830ac7212da192ba7ae9ef1ad73a2851d0d943f61c74245f70863</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1989</creationdate><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Catecholaminergic system</topic><topic>Electroretinography</topic><topic>Evoked Potentials, Visual</topic><topic>Female</topic><topic>Hydroxydopamines - pharmacology</topic><topic>Injections</topic><topic>Macaca fascicularis</topic><topic>Medical sciences</topic><topic>Neuropharmacology</topic><topic>Neurotransmitters. Neurotransmission. Receptors</topic><topic>Oxidopamine</topic><topic>Pharmacology. Drug treatments</topic><topic>Retina - drug effects</topic><topic>Retina - physiology</topic><topic>Vitreous Body</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ghilardi, Maria Felice</creatorcontrib><creatorcontrib>Marx, Marcia S.</creatorcontrib><creatorcontrib>Bodis-Wollner, Ivan</creatorcontrib><creatorcontrib>Camras, Carl B.</creatorcontrib><creatorcontrib>Glover, Andrew A.</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Annals of neurology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ghilardi, Maria Felice</au><au>Marx, Marcia S.</au><au>Bodis-Wollner, Ivan</au><au>Camras, Carl B.</au><au>Glover, Andrew A.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The effect of intraocular 6-hydroxydopamine on retinal processing of primates</atitle><jtitle>Annals of neurology</jtitle><addtitle>Ann Neurol</addtitle><date>1989-04</date><risdate>1989</risdate><volume>25</volume><issue>4</issue><spage>357</spage><epage>364</epage><pages>357-364</pages><issn>0364-5134</issn><eissn>1531-8249</eissn><coden>ANNED3</coden><abstract>In previous studies, we showed that in the monkey, systemically administered N‐methyl, 4‐phenyl, 1‐2‐3‐6 tetrahydropyridine (MPTP) produces a chronic parkinsonian syndrome accompanied by spatial frequency‐dependent abnormalities in both the pattern electroretinogram and visual evoked potential. We describe the effect of intravitreally administered 6‐hydroxydopamine (6‐OH‐DA) on the pattern electroretinogram and pattern visual evoked potential of 3 aphakic monkeys. Because of the aphake condition, several complexities of intravitreal injection of 6‐OH‐DA could be avoided. Nevertheless, following 6‐OH‐DA treatment, both the phase and the amplitude of pattern electroretinogram and pattern visual evoked potential became abnormal. This abnormality was most pronounced for the higher spatial frequencies (2.5 and 3.5 cycles per degree), whereas lower spatial frequencies (0.5 and 1.2 cycles per degree) were less impaired. The effects of systemically administered MPTP on pattern electroretinogram and pattern visual evoked potential are similar to the effects of intravitreal injections of 6‐OH‐DA, suggesting that a retinal catecholaminergic system plays an important role in pattern vision of primates.</abstract><cop>Hoboken</cop><pub>Wiley Subscription Services, Inc., A Wiley Company</pub><pmid>2496639</pmid><doi>10.1002/ana.410250407</doi><tpages>8</tpages></addata></record> |
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| ispartof | Annals of neurology, 1989-04, Vol.25 (4), p.357-364 |
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| subjects | Animals Biological and medical sciences Catecholaminergic system Electroretinography Evoked Potentials, Visual Female Hydroxydopamines - pharmacology Injections Macaca fascicularis Medical sciences Neuropharmacology Neurotransmitters. Neurotransmission. Receptors Oxidopamine Pharmacology. Drug treatments Retina - drug effects Retina - physiology Vitreous Body |
| title | The effect of intraocular 6-hydroxydopamine on retinal processing of primates |
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