Endogenous basic fibroblast growth factor displaced by heparin from the lumenal surface of human blood vessels is preferentially sequestered by injured regions of the vessel wall

Proliferation of smooth muscle cells (SMCs) of the arterial wall in response to local injury is an important factor in vascular proliferative disorders. Among the growth factors that promote SMC proliferation is basic fibroblast growth factor (bFGF), which is characterized by a high affinity for hep...

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Veröffentlicht in:	Circulation (New York, N.Y.) N.Y.), 1997-04, Vol.95 (7), p.1853-1862
Hauptverfasser:	MEDALION, B, MERIN, G, AINGORN, H, MIAO, H.-Q, NAGLER, A, ELAMI, A, ISHAI-MICHAELI, R, VLODAVSKY, I
Format:	Artikel
Sprache:	eng
Schlagworte:	3T3 Cells Animals Binding, Competitive Biological and medical sciences Blood. Blood coagulation. Reticuloendothelial system Cardiopulmonary Bypass Cattle Cell Division - drug effects Endothelium, Vascular - metabolism Fibroblast Growth Factor 2 - metabolism Fibroblast Growth Factor 2 - pharmacology Heparin - pharmacology Heparin Lyase Heparitin Sulfate - metabolism Humans Medical sciences Mice Muscle, Smooth, Vascular - pathology Perfusion Pharmacology. Drug treatments Phenoxyacetates - pharmacology Polymers - pharmacology Polysaccharide-Lyases - pharmacology Receptors, Fibroblast Growth Factor - drug effects Receptors, Fibroblast Growth Factor - metabolism Recombinant Proteins - pharmacology Saphenous Vein - drug effects Saphenous Vein - injuries Saphenous Vein - metabolism
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