Growth performance, endocrine, and metabolite responses of finishing hogs to porcine prolactin

Prolactin, a member of the somatotropin-prolactin-placental lactogen gene family, increases feed intake and rate of weight gain in several species. To determine whether prolactin affects growth performance and carcass composition in swine, recombinant porcine prolactin (rpPRL) was administered to fi...

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Veröffentlicht in:Journal of animal science 1997-04, Vol.75 (4), p.959-967
Hauptverfasser: McLaughlin, C.L. (Protiva, St. Louis, MO.), Byatt, J.C, Curran, D.F, Veenhuizen, J.J, McGrath, M.F, Buonomo, F.C, Hintz, R.L, Baile, C.A
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container_issue 4
container_start_page 959
container_title Journal of animal science
container_volume 75
creator McLaughlin, C.L. (Protiva, St. Louis, MO.)
Byatt, J.C
Curran, D.F
Veenhuizen, J.J
McGrath, M.F
Buonomo, F.C
Hintz, R.L
Baile, C.A
description Prolactin, a member of the somatotropin-prolactin-placental lactogen gene family, increases feed intake and rate of weight gain in several species. To determine whether prolactin affects growth performance and carcass composition in swine, recombinant porcine prolactin (rpPRL) was administered to finishing hogs. Doses of 0, 2, 4, 8, and 16 mg of rpPRL/d and 4 mg of recombinant porcine somatotropin (rpST)/d were administered to groups of seven barrows and seven gilts initially weighing 75.0 +/- 2 kg for a 28-d period. Recombinant pPRL did not alter feed intake or growth rate or affect carcass composition. In addition, most growth-related blood variables did not change, although plasma IGF-I was increased in the 8 and 16 mg of rpPRL treatment groups. At slaughter, mammary development was apparent in rpPRL-treated gilts and was characterized by distended alveolar and ductal lumina and presence of secretory material. In rPST-treated hogs, feed intake was decreased 28% (P 0.01), gain/feed was increased more in barrows than in gilts (59 vs 39%, treatment X sex interaction, P
doi_str_mv 10.2527/1997.754959x
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(Protiva, St. Louis, MO.) ; Byatt, J.C ; Curran, D.F ; Veenhuizen, J.J ; McGrath, M.F ; Buonomo, F.C ; Hintz, R.L ; Baile, C.A</creator><creatorcontrib>McLaughlin, C.L. (Protiva, St. Louis, MO.) ; Byatt, J.C ; Curran, D.F ; Veenhuizen, J.J ; McGrath, M.F ; Buonomo, F.C ; Hintz, R.L ; Baile, C.A</creatorcontrib><description>Prolactin, a member of the somatotropin-prolactin-placental lactogen gene family, increases feed intake and rate of weight gain in several species. To determine whether prolactin affects growth performance and carcass composition in swine, recombinant porcine prolactin (rpPRL) was administered to finishing hogs. Doses of 0, 2, 4, 8, and 16 mg of rpPRL/d and 4 mg of recombinant porcine somatotropin (rpST)/d were administered to groups of seven barrows and seven gilts initially weighing 75.0 +/- 2 kg for a 28-d period. Recombinant pPRL did not alter feed intake or growth rate or affect carcass composition. 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Psychology ; GAIN DE POIDS ; GANANCIA DE PESO ; GLANDE MAMMAIRE ; GLANDULAS MAMARIAS ; Growth Hormone - administration &amp; dosage ; Growth Hormone - pharmacology ; Hogs ; Hormones ; INDICE DE CRECIMIENTO ; INGESTION DE PIENSOS ; Injections ; Insulin - blood ; Insulin-Like Growth Factor I - analysis ; Insulin-Like Growth Factor I - metabolism ; INSULINA ; INSULINE ; Iodine Radioisotopes ; Male ; Mammary Glands, Animal - cytology ; Mammary Glands, Animal - physiology ; Metabolism ; MUSCLE ; Muscle, Skeletal - anatomy &amp; histology ; Muscle, Skeletal - drug effects ; MUSCULOS ; Physical growth ; PLASMA SANGUIN ; PLASMA SANGUINEO ; PORCIN ; PRISE ALIMENTAIRE (ANIMAUX) ; Prolactin - administration &amp; dosage ; Prolactin - pharmacology ; PROLACTINA ; PROLACTINE ; Proteins - metabolism ; Random Allocation ; Rats ; Rats, Sprague-Dawley ; Recombinant Proteins - administration &amp; dosage ; Recombinant Proteins - pharmacology ; SEXE ; SEXO ; SOMATOTROPINA ; SOMATOTROPINE ; SUCRE DU SANG ; Swine - growth &amp; development ; Swine - metabolism ; Swine - physiology ; TAUX DE CROISSANCE ; TEJIDOS ANIMALES ; Terrestrial animal productions ; TISSU ANIMAL ; TRUIE ; UREA ; UREE ; Vertebrates ; Weight Gain - drug effects ; Weight Gain - physiology</subject><ispartof>Journal of animal science, 1997-04, Vol.75 (4), p.959-967</ispartof><rights>1997 INIST-CNRS</rights><rights>Copyright American Society of Animal Science Apr 1997</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c391t-6fa2b803e28da9edaffa32bbd778e9a300987257690a53c1e2c56348035bf58b3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&amp;idt=2627168$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/9110208$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>McLaughlin, C.L. (Protiva, St. Louis, MO.)</creatorcontrib><creatorcontrib>Byatt, J.C</creatorcontrib><creatorcontrib>Curran, D.F</creatorcontrib><creatorcontrib>Veenhuizen, J.J</creatorcontrib><creatorcontrib>McGrath, M.F</creatorcontrib><creatorcontrib>Buonomo, F.C</creatorcontrib><creatorcontrib>Hintz, R.L</creatorcontrib><creatorcontrib>Baile, C.A</creatorcontrib><title>Growth performance, endocrine, and metabolite responses of finishing hogs to porcine prolactin</title><title>Journal of animal science</title><addtitle>J Anim Sci</addtitle><description>Prolactin, a member of the somatotropin-prolactin-placental lactogen gene family, increases feed intake and rate of weight gain in several species. To determine whether prolactin affects growth performance and carcass composition in swine, recombinant porcine prolactin (rpPRL) was administered to finishing hogs. 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In rPST-treated hogs, feed intake was decreased 28% (P 0.01), gain/feed was increased more in barrows than in gilts (59 vs 39%, treatment X sex interaction, P</description><subject>Analysis of Variance</subject><subject>Animal productions</subject><subject>Animals</subject><subject>AZUCAR EN SANGRE</subject><subject>Biological and medical sciences</subject><subject>Blood Glucose - analysis</subject><subject>Blood Glucose - metabolism</subject><subject>Blood Urea Nitrogen</subject><subject>Body Composition - drug effects</subject><subject>Body Composition - physiology</subject><subject>Carbohydrate Metabolism</subject><subject>CERDAS</subject><subject>CERDO</subject><subject>Coloring Agents</subject><subject>COMPOSICION DE LA CANAL</subject><subject>COMPOSICION DE LA SANGRE</subject><subject>COMPOSITION DE LA CARCASSE</subject><subject>COMPOSITION DU SANG</subject><subject>DIFERENCIAS BIOLOGICAS</subject><subject>DIFFERENCE BIOLOGIQUE</subject><subject>Dose-Response Relationship, Drug</subject><subject>Eating - drug effects</subject><subject>Eating - physiology</subject><subject>EFFICACITE ALIMENTAIRE</subject><subject>EFICIENCIA DE CONVERSION DEL PIENSO</subject><subject>Endocrine Glands - drug effects</subject><subject>Endocrine Glands - physiology</subject><subject>FACTEUR DE CROISSANCE IGF</subject><subject>FACTOR DE CRECIMIENTO IGF</subject><subject>Female</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>GAIN DE POIDS</subject><subject>GANANCIA DE PESO</subject><subject>GLANDE MAMMAIRE</subject><subject>GLANDULAS MAMARIAS</subject><subject>Growth Hormone - administration &amp; dosage</subject><subject>Growth Hormone - pharmacology</subject><subject>Hogs</subject><subject>Hormones</subject><subject>INDICE DE CRECIMIENTO</subject><subject>INGESTION DE PIENSOS</subject><subject>Injections</subject><subject>Insulin - blood</subject><subject>Insulin-Like Growth Factor I - analysis</subject><subject>Insulin-Like Growth Factor I - metabolism</subject><subject>INSULINA</subject><subject>INSULINE</subject><subject>Iodine Radioisotopes</subject><subject>Male</subject><subject>Mammary Glands, Animal - cytology</subject><subject>Mammary Glands, Animal - physiology</subject><subject>Metabolism</subject><subject>MUSCLE</subject><subject>Muscle, Skeletal - anatomy &amp; histology</subject><subject>Muscle, Skeletal - drug effects</subject><subject>MUSCULOS</subject><subject>Physical growth</subject><subject>PLASMA SANGUIN</subject><subject>PLASMA SANGUINEO</subject><subject>PORCIN</subject><subject>PRISE ALIMENTAIRE (ANIMAUX)</subject><subject>Prolactin - administration &amp; dosage</subject><subject>Prolactin - pharmacology</subject><subject>PROLACTINA</subject><subject>PROLACTINE</subject><subject>Proteins - metabolism</subject><subject>Random Allocation</subject><subject>Rats</subject><subject>Rats, Sprague-Dawley</subject><subject>Recombinant Proteins - administration &amp; dosage</subject><subject>Recombinant Proteins - pharmacology</subject><subject>SEXE</subject><subject>SEXO</subject><subject>SOMATOTROPINA</subject><subject>SOMATOTROPINE</subject><subject>SUCRE DU SANG</subject><subject>Swine - growth &amp; development</subject><subject>Swine - metabolism</subject><subject>Swine - physiology</subject><subject>TAUX DE CROISSANCE</subject><subject>TEJIDOS ANIMALES</subject><subject>Terrestrial animal productions</subject><subject>TISSU ANIMAL</subject><subject>TRUIE</subject><subject>UREA</subject><subject>UREE</subject><subject>Vertebrates</subject><subject>Weight Gain - drug effects</subject><subject>Weight Gain - physiology</subject><issn>0021-8812</issn><issn>1525-3163</issn><issn>0021-8812</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1997</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpdkM9rFTEQx4Mo9Vm9eRKEUKynbs2PzSY5StEqFDxor4bZbPI2j91kTfZR_e_N4z166GkG5jPfGT4IvaXkmgkmP1Gt5bUUrRb67zO0oYKJhtOOP0cbQhhtlKLsJXpVyo4QyoQWZ-hMU0oYURv0-zanh3XEi8s-5RmidVfYxSHZHGJtIQ54div0aQqrw9mVJcXiCk4e-xBDGUPc4jFtC14TXlK2dQ0vOU1g1xBfoxcepuLenOo5uv_65dfNt-bux-33m893jeWark3ngfWKcMfUANoN4D1w1veDlMpp4IRoJZmQnSYguKWOWdHxtm6I3gvV83P08ZhbL__Zu7KaORTrpgmiS_tipKp2JNcVvHgC7tI-x_qbYVRR2jGmKnR1hGxOpWTnzZLDDPmfocQcnJuDc3NyXvH3p8x9P7vhET5JrvMPpzkUC5PP1XIojxjrmKTdAbs8YmPYjg8hO1NmmKYaSs0OihSmNfVe5d4dOQ_JwDbXqPufWrat6CT_DwYingc</recordid><startdate>19970401</startdate><enddate>19970401</enddate><creator>McLaughlin, C.L. 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(Protiva, St. Louis, MO.) ; Byatt, J.C ; Curran, D.F ; Veenhuizen, J.J ; McGrath, M.F ; Buonomo, F.C ; Hintz, R.L ; Baile, C.A</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c391t-6fa2b803e28da9edaffa32bbd778e9a300987257690a53c1e2c56348035bf58b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1997</creationdate><topic>Analysis of Variance</topic><topic>Animal productions</topic><topic>Animals</topic><topic>AZUCAR EN SANGRE</topic><topic>Biological and medical sciences</topic><topic>Blood Glucose - analysis</topic><topic>Blood Glucose - metabolism</topic><topic>Blood Urea Nitrogen</topic><topic>Body Composition - drug effects</topic><topic>Body Composition - physiology</topic><topic>Carbohydrate Metabolism</topic><topic>CERDAS</topic><topic>CERDO</topic><topic>Coloring Agents</topic><topic>COMPOSICION DE LA CANAL</topic><topic>COMPOSICION DE LA SANGRE</topic><topic>COMPOSITION DE LA CARCASSE</topic><topic>COMPOSITION DU SANG</topic><topic>DIFERENCIAS BIOLOGICAS</topic><topic>DIFFERENCE BIOLOGIQUE</topic><topic>Dose-Response Relationship, Drug</topic><topic>Eating - drug effects</topic><topic>Eating - physiology</topic><topic>EFFICACITE ALIMENTAIRE</topic><topic>EFICIENCIA DE CONVERSION DEL PIENSO</topic><topic>Endocrine Glands - drug effects</topic><topic>Endocrine Glands - physiology</topic><topic>FACTEUR DE CROISSANCE IGF</topic><topic>FACTOR DE CRECIMIENTO IGF</topic><topic>Female</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>GAIN DE POIDS</topic><topic>GANANCIA DE PESO</topic><topic>GLANDE MAMMAIRE</topic><topic>GLANDULAS MAMARIAS</topic><topic>Growth Hormone - administration &amp; dosage</topic><topic>Growth Hormone - pharmacology</topic><topic>Hogs</topic><topic>Hormones</topic><topic>INDICE DE CRECIMIENTO</topic><topic>INGESTION DE PIENSOS</topic><topic>Injections</topic><topic>Insulin - blood</topic><topic>Insulin-Like Growth Factor I - analysis</topic><topic>Insulin-Like Growth Factor I - metabolism</topic><topic>INSULINA</topic><topic>INSULINE</topic><topic>Iodine Radioisotopes</topic><topic>Male</topic><topic>Mammary Glands, Animal - cytology</topic><topic>Mammary Glands, Animal - physiology</topic><topic>Metabolism</topic><topic>MUSCLE</topic><topic>Muscle, Skeletal - anatomy &amp; histology</topic><topic>Muscle, Skeletal - drug effects</topic><topic>MUSCULOS</topic><topic>Physical growth</topic><topic>PLASMA SANGUIN</topic><topic>PLASMA SANGUINEO</topic><topic>PORCIN</topic><topic>PRISE ALIMENTAIRE (ANIMAUX)</topic><topic>Prolactin - administration &amp; dosage</topic><topic>Prolactin - pharmacology</topic><topic>PROLACTINA</topic><topic>PROLACTINE</topic><topic>Proteins - metabolism</topic><topic>Random Allocation</topic><topic>Rats</topic><topic>Rats, Sprague-Dawley</topic><topic>Recombinant Proteins - administration &amp; dosage</topic><topic>Recombinant Proteins - pharmacology</topic><topic>SEXE</topic><topic>SEXO</topic><topic>SOMATOTROPINA</topic><topic>SOMATOTROPINE</topic><topic>SUCRE DU SANG</topic><topic>Swine - growth &amp; development</topic><topic>Swine - metabolism</topic><topic>Swine - physiology</topic><topic>TAUX DE CROISSANCE</topic><topic>TEJIDOS ANIMALES</topic><topic>Terrestrial animal productions</topic><topic>TISSU ANIMAL</topic><topic>TRUIE</topic><topic>UREA</topic><topic>UREE</topic><topic>Vertebrates</topic><topic>Weight Gain - drug effects</topic><topic>Weight Gain - physiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>McLaughlin, C.L. 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(Protiva, St. Louis, MO.)</au><au>Byatt, J.C</au><au>Curran, D.F</au><au>Veenhuizen, J.J</au><au>McGrath, M.F</au><au>Buonomo, F.C</au><au>Hintz, R.L</au><au>Baile, C.A</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Growth performance, endocrine, and metabolite responses of finishing hogs to porcine prolactin</atitle><jtitle>Journal of animal science</jtitle><addtitle>J Anim Sci</addtitle><date>1997-04-01</date><risdate>1997</risdate><volume>75</volume><issue>4</issue><spage>959</spage><epage>967</epage><pages>959-967</pages><issn>0021-8812</issn><eissn>1525-3163</eissn><eissn>0021-8812</eissn><abstract>Prolactin, a member of the somatotropin-prolactin-placental lactogen gene family, increases feed intake and rate of weight gain in several species. To determine whether prolactin affects growth performance and carcass composition in swine, recombinant porcine prolactin (rpPRL) was administered to finishing hogs. Doses of 0, 2, 4, 8, and 16 mg of rpPRL/d and 4 mg of recombinant porcine somatotropin (rpST)/d were administered to groups of seven barrows and seven gilts initially weighing 75.0 +/- 2 kg for a 28-d period. Recombinant pPRL did not alter feed intake or growth rate or affect carcass composition. In addition, most growth-related blood variables did not change, although plasma IGF-I was increased in the 8 and 16 mg of rpPRL treatment groups. At slaughter, mammary development was apparent in rpPRL-treated gilts and was characterized by distended alveolar and ductal lumina and presence of secretory material. In rPST-treated hogs, feed intake was decreased 28% (P 0.01), gain/feed was increased more in barrows than in gilts (59 vs 39%, treatment X sex interaction, P</abstract><cop>Savoy, IL</cop><pub>Am Soc Animal Sci</pub><pmid>9110208</pmid><doi>10.2527/1997.754959x</doi><tpages>9</tpages></addata></record>
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ispartof Journal of animal science, 1997-04, Vol.75 (4), p.959-967
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source MEDLINE; Oxford University Press Journals All Titles (1996-Current)
subjects Analysis of Variance
Animal productions
Animals
AZUCAR EN SANGRE
Biological and medical sciences
Blood Glucose - analysis
Blood Glucose - metabolism
Blood Urea Nitrogen
Body Composition - drug effects
Body Composition - physiology
Carbohydrate Metabolism
CERDAS
CERDO
Coloring Agents
COMPOSICION DE LA CANAL
COMPOSICION DE LA SANGRE
COMPOSITION DE LA CARCASSE
COMPOSITION DU SANG
DIFERENCIAS BIOLOGICAS
DIFFERENCE BIOLOGIQUE
Dose-Response Relationship, Drug
Eating - drug effects
Eating - physiology
EFFICACITE ALIMENTAIRE
EFICIENCIA DE CONVERSION DEL PIENSO
Endocrine Glands - drug effects
Endocrine Glands - physiology
FACTEUR DE CROISSANCE IGF
FACTOR DE CRECIMIENTO IGF
Female
Fundamental and applied biological sciences. Psychology
GAIN DE POIDS
GANANCIA DE PESO
GLANDE MAMMAIRE
GLANDULAS MAMARIAS
Growth Hormone - administration & dosage
Growth Hormone - pharmacology
Hogs
Hormones
INDICE DE CRECIMIENTO
INGESTION DE PIENSOS
Injections
Insulin - blood
Insulin-Like Growth Factor I - analysis
Insulin-Like Growth Factor I - metabolism
INSULINA
INSULINE
Iodine Radioisotopes
Male
Mammary Glands, Animal - cytology
Mammary Glands, Animal - physiology
Metabolism
MUSCLE
Muscle, Skeletal - anatomy & histology
Muscle, Skeletal - drug effects
MUSCULOS
Physical growth
PLASMA SANGUIN
PLASMA SANGUINEO
PORCIN
PRISE ALIMENTAIRE (ANIMAUX)
Prolactin - administration & dosage
Prolactin - pharmacology
PROLACTINA
PROLACTINE
Proteins - metabolism
Random Allocation
Rats
Rats, Sprague-Dawley
Recombinant Proteins - administration & dosage
Recombinant Proteins - pharmacology
SEXE
SEXO
SOMATOTROPINA
SOMATOTROPINE
SUCRE DU SANG
Swine - growth & development
Swine - metabolism
Swine - physiology
TAUX DE CROISSANCE
TEJIDOS ANIMALES
Terrestrial animal productions
TISSU ANIMAL
TRUIE
UREA
UREE
Vertebrates
Weight Gain - drug effects
Weight Gain - physiology
title Growth performance, endocrine, and metabolite responses of finishing hogs to porcine prolactin
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