Interleukin-12 and tumor necrosis factor-α levels in cerebrospinal fluid of multiple sclerosis patients
Concentrations of interleukin (IL)-12 and tumor necrosis factor-α (TNF-α) in cerebrospinal fluid (CSF) were measured in patients with multiple sclerosis (MS) and control patients with non-inflammatory neurological diseases (NIND) by an enzyme-linked immunosorbent assay. TNF-α was detectable in the C...
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| Veröffentlicht in: | Journal of the neurological sciences 1997-04, Vol.147 (2), p.145-150 |
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| container_issue | 2 |
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| container_title | Journal of the neurological sciences |
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| creator | Drulović, Jelena Mostarica-Stojković, Marija Lević, Zvonimir Stojsavljević, Nebojša Pravica, Vera Mesaroš, Šarlota |
| description | Concentrations of interleukin (IL)-12 and tumor necrosis factor-α (TNF-α) in cerebrospinal fluid (CSF) were measured in patients with multiple sclerosis (MS) and control patients with non-inflammatory neurological diseases (NIND) by an enzyme-linked immunosorbent assay. TNF-α was detectable in the CSF of 60% of the patients with active MS, none of those with inactive MS and 29% of patients with NIND. CSF concentrations of TNF-α correlated with the degree of disability in MS patients (
P < 0.05). Detectable levels of IL-12 were found in 10% of the MS CSF samples and 18% of NIND CSF samples. There was a significant relationship between CSF concentrations of IL-12 and those of TNF-α in MS patients (
P < 0.05); no relationship was observed between the presence of IL-12 and disease activity or severity. These findings further stress the involvement of T helper 1 type-response within the central nervous system in MS. |
| doi_str_mv | 10.1016/S0022-510X(96)05320-8 |
| format | Article |
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P < 0.05). Detectable levels of IL-12 were found in 10% of the MS CSF samples and 18% of NIND CSF samples. There was a significant relationship between CSF concentrations of IL-12 and those of TNF-α in MS patients (
P < 0.05); no relationship was observed between the presence of IL-12 and disease activity or severity. These findings further stress the involvement of T helper 1 type-response within the central nervous system in MS.</description><identifier>ISSN: 0022-510X</identifier><identifier>EISSN: 1878-5883</identifier><identifier>DOI: 10.1016/S0022-510X(96)05320-8</identifier><identifier>PMID: 9106119</identifier><identifier>CODEN: JNSCAG</identifier><language>eng</language><publisher>Shannon: Elsevier B.V</publisher><subject>Adult ; Biological and medical sciences ; Cerebrospinal fluid ; Data Interpretation, Statistical ; Enzyme-Linked Immunosorbent Assay ; Female ; Humans ; Interleukin-12 ; Interleukin-12 - cerebrospinal fluid ; Male ; Medical sciences ; Multiple sclerosis ; Multiple Sclerosis - cerebrospinal fluid ; Multiple sclerosis and variants. Guillain barré syndrome and other inflammatory polyneuropathies. Leukoencephalitis ; Nervous System Diseases - cerebrospinal fluid ; Neurology ; Tumor Necrosis Factor-alpha - cerebrospinal fluid ; Tumor necrosis factor-α</subject><ispartof>Journal of the neurological sciences, 1997-04, Vol.147 (2), p.145-150</ispartof><rights>1997</rights><rights>1997 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c420t-796695d1e83169b42fa37c8149e5d5343e880fa09679b96521d2bd353a700a43</citedby><cites>FETCH-LOGICAL-c420t-796695d1e83169b42fa37c8149e5d5343e880fa09679b96521d2bd353a700a43</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/S0022-510X(96)05320-8$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3548,27922,27923,45993</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=2628604$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/9106119$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Drulović, Jelena</creatorcontrib><creatorcontrib>Mostarica-Stojković, Marija</creatorcontrib><creatorcontrib>Lević, Zvonimir</creatorcontrib><creatorcontrib>Stojsavljević, Nebojša</creatorcontrib><creatorcontrib>Pravica, Vera</creatorcontrib><creatorcontrib>Mesaroš, Šarlota</creatorcontrib><title>Interleukin-12 and tumor necrosis factor-α levels in cerebrospinal fluid of multiple sclerosis patients</title><title>Journal of the neurological sciences</title><addtitle>J Neurol Sci</addtitle><description>Concentrations of interleukin (IL)-12 and tumor necrosis factor-α (TNF-α) in cerebrospinal fluid (CSF) were measured in patients with multiple sclerosis (MS) and control patients with non-inflammatory neurological diseases (NIND) by an enzyme-linked immunosorbent assay. TNF-α was detectable in the CSF of 60% of the patients with active MS, none of those with inactive MS and 29% of patients with NIND. CSF concentrations of TNF-α correlated with the degree of disability in MS patients (
P < 0.05). Detectable levels of IL-12 were found in 10% of the MS CSF samples and 18% of NIND CSF samples. There was a significant relationship between CSF concentrations of IL-12 and those of TNF-α in MS patients (
P < 0.05); no relationship was observed between the presence of IL-12 and disease activity or severity. These findings further stress the involvement of T helper 1 type-response within the central nervous system in MS.</description><subject>Adult</subject><subject>Biological and medical sciences</subject><subject>Cerebrospinal fluid</subject><subject>Data Interpretation, Statistical</subject><subject>Enzyme-Linked Immunosorbent Assay</subject><subject>Female</subject><subject>Humans</subject><subject>Interleukin-12</subject><subject>Interleukin-12 - cerebrospinal fluid</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Multiple sclerosis</subject><subject>Multiple Sclerosis - cerebrospinal fluid</subject><subject>Multiple sclerosis and variants. Guillain barré syndrome and other inflammatory polyneuropathies. Leukoencephalitis</subject><subject>Nervous System Diseases - cerebrospinal fluid</subject><subject>Neurology</subject><subject>Tumor Necrosis Factor-alpha - cerebrospinal fluid</subject><subject>Tumor necrosis factor-α</subject><issn>0022-510X</issn><issn>1878-5883</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1997</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkcFu1TAQRS0EKq-FT6jkBUKwCIzt2LFXCFVQKlViQRfsLMeZCIPjBNupxGfxI3wTeX1Pb9uVF_fcGc-9hFwyeMeAqfffADhvJIPvb4x6C1JwaPQTsmO6043UWjwluxPynJyX8hMAlNbmjJwZBooxsyM_blLFHHH9FVLDOHVpoHWd5kwT-jyXUOjofJ1z8-8vjXiPsdCQqMeM_SYvIblIx7iGgc4jndZYwxKRFh_x4F5cDZhqeUGejS4WfHl8L8jd5093V1-a26_XN1cfbxvfcqhNZ5QycmCoBVOmb_noROc1aw3KQYpWoNYwOjCqM71RkrOB94OQwnUArhUX5PVh7JLn3yuWaqdQPMboEs5rsZ02UitpHgWZEoLzVmygPID7OErG0S45TC7_sQzsvgn70ITdx2yNsg9NWL35Lo8L1n7C4eQ6Rr_pr466K97FMbvkQzlhXHGtYH_QhwO2JY_3AbMtfgvU4xAy-mqHOTzykf_KMKXm</recordid><startdate>19970415</startdate><enddate>19970415</enddate><creator>Drulović, Jelena</creator><creator>Mostarica-Stojković, Marija</creator><creator>Lević, Zvonimir</creator><creator>Stojsavljević, Nebojša</creator><creator>Pravica, Vera</creator><creator>Mesaroš, Šarlota</creator><general>Elsevier B.V</general><general>Elsevier Science</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>7X8</scope></search><sort><creationdate>19970415</creationdate><title>Interleukin-12 and tumor necrosis factor-α levels in cerebrospinal fluid of multiple sclerosis patients</title><author>Drulović, Jelena ; Mostarica-Stojković, Marija ; Lević, Zvonimir ; Stojsavljević, Nebojša ; Pravica, Vera ; Mesaroš, Šarlota</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c420t-796695d1e83169b42fa37c8149e5d5343e880fa09679b96521d2bd353a700a43</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1997</creationdate><topic>Adult</topic><topic>Biological and medical sciences</topic><topic>Cerebrospinal fluid</topic><topic>Data Interpretation, Statistical</topic><topic>Enzyme-Linked Immunosorbent Assay</topic><topic>Female</topic><topic>Humans</topic><topic>Interleukin-12</topic><topic>Interleukin-12 - cerebrospinal fluid</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Multiple sclerosis</topic><topic>Multiple Sclerosis - cerebrospinal fluid</topic><topic>Multiple sclerosis and variants. Guillain barré syndrome and other inflammatory polyneuropathies. Leukoencephalitis</topic><topic>Nervous System Diseases - cerebrospinal fluid</topic><topic>Neurology</topic><topic>Tumor Necrosis Factor-alpha - cerebrospinal fluid</topic><topic>Tumor necrosis factor-α</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Drulović, Jelena</creatorcontrib><creatorcontrib>Mostarica-Stojković, Marija</creatorcontrib><creatorcontrib>Lević, Zvonimir</creatorcontrib><creatorcontrib>Stojsavljević, Nebojša</creatorcontrib><creatorcontrib>Pravica, Vera</creatorcontrib><creatorcontrib>Mesaroš, Šarlota</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of the neurological sciences</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Drulović, Jelena</au><au>Mostarica-Stojković, Marija</au><au>Lević, Zvonimir</au><au>Stojsavljević, Nebojša</au><au>Pravica, Vera</au><au>Mesaroš, Šarlota</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Interleukin-12 and tumor necrosis factor-α levels in cerebrospinal fluid of multiple sclerosis patients</atitle><jtitle>Journal of the neurological sciences</jtitle><addtitle>J Neurol Sci</addtitle><date>1997-04-15</date><risdate>1997</risdate><volume>147</volume><issue>2</issue><spage>145</spage><epage>150</epage><pages>145-150</pages><issn>0022-510X</issn><eissn>1878-5883</eissn><coden>JNSCAG</coden><abstract>Concentrations of interleukin (IL)-12 and tumor necrosis factor-α (TNF-α) in cerebrospinal fluid (CSF) were measured in patients with multiple sclerosis (MS) and control patients with non-inflammatory neurological diseases (NIND) by an enzyme-linked immunosorbent assay. TNF-α was detectable in the CSF of 60% of the patients with active MS, none of those with inactive MS and 29% of patients with NIND. CSF concentrations of TNF-α correlated with the degree of disability in MS patients (
P < 0.05). Detectable levels of IL-12 were found in 10% of the MS CSF samples and 18% of NIND CSF samples. There was a significant relationship between CSF concentrations of IL-12 and those of TNF-α in MS patients (
P < 0.05); no relationship was observed between the presence of IL-12 and disease activity or severity. These findings further stress the involvement of T helper 1 type-response within the central nervous system in MS.</abstract><cop>Shannon</cop><pub>Elsevier B.V</pub><pmid>9106119</pmid><doi>10.1016/S0022-510X(96)05320-8</doi><tpages>6</tpages></addata></record> |
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| ispartof | Journal of the neurological sciences, 1997-04, Vol.147 (2), p.145-150 |
| issn | 0022-510X 1878-5883 |
| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals Complete |
| subjects | Adult Biological and medical sciences Cerebrospinal fluid Data Interpretation, Statistical Enzyme-Linked Immunosorbent Assay Female Humans Interleukin-12 Interleukin-12 - cerebrospinal fluid Male Medical sciences Multiple sclerosis Multiple Sclerosis - cerebrospinal fluid Multiple sclerosis and variants. Guillain barré syndrome and other inflammatory polyneuropathies. Leukoencephalitis Nervous System Diseases - cerebrospinal fluid Neurology Tumor Necrosis Factor-alpha - cerebrospinal fluid Tumor necrosis factor-α |
| title | Interleukin-12 and tumor necrosis factor-α levels in cerebrospinal fluid of multiple sclerosis patients |
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