Role of Ureaplasma urealyticum and Chlamydia trachomatis in development of bronchopulmonary dysplasia in very low birth weight infants
OBJECTIVE.To investigate the relationship between Ureaplasma urealyticum and Chlamydia trachomatis colonization of the very low birth weight infant and the development of bronchopulmonary dysplasia (BPD). METHODS.Endotracheal and/or nasopharyngeal aspirates and clinical data were obtained prospectiv...
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| Veröffentlicht in: | The Pediatric infectious disease journal 1997-04, Vol.16 (4), p.364-369 |
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| creator | DA SILVA, ORLANDO GREGSON, DANIEL HAMMERBERG, OLE |
| description | OBJECTIVE.To investigate the relationship between Ureaplasma urealyticum and Chlamydia trachomatis colonization of the very low birth weight infant and the development of bronchopulmonary dysplasia (BPD).
METHODS.Endotracheal and/or nasopharyngeal aspirates and clinical data were obtained prospectively from 108 infants with a birth weight of |
| doi_str_mv | 10.1097/00006454-199704000-00006 |
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| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_78957208</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>16279996</sourcerecordid><originalsourceid>FETCH-LOGICAL-c5106-8737c3d6f071571d3fe0b2b8fb0b6c9b090aa1542d40cd0696be1546da692bfc3</originalsourceid><addsrcrecordid>eNqFkt9uFCEYxYnR1G31EUy4MN5NC8MMDJdmY9WkSRNjrwl_nVEYRmC62Rfoc8u6270zcgN85_cdIAcAIEbXGHF2g-qgXd81mHOGurpr_pZegA3uSdsgPrCXYIMGjhtC6fAaXOb8sxKkw-gCXPDqggnbgKdv0VsYHXxIVi5e5iDhWpd-Xya9BihnA7ejl2FvJglLknqMQZYpw2mGxj5aH5dg53KwUCnOVV5WH-Is0x6afT5Y1sYKP9pa8XEH1ZTKCHd2-jGWKjg5l_wGvHLSZ_v2NF-Bh9tP37dfmrv7z1-3H-8a3WNEm4ERpomhDjHcM2yIs0i1anAKKaq5QhxJifuuNR3SBlFOla1baiTlrXKaXIEPR98lxd-rzUWEKWvrvZxtXLNgA-9Zi4b_gpi2jHNOKzgcQZ1izsk6saQp1NcLjMQhK_GclThndSzV1nenM1YVrDk3nsKp-vuTLrOW3iU56ymfsZbWZOnhqt0R20VfbMq__LqzSYw1xDKKf_0U8gfRU649</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>16279996</pqid></control><display><type>article</type><title>Role of Ureaplasma urealyticum and Chlamydia trachomatis in development of bronchopulmonary dysplasia in very low birth weight infants</title><source>MEDLINE</source><source>Journals@Ovid Complete</source><creator>DA SILVA, ORLANDO ; GREGSON, DANIEL ; HAMMERBERG, OLE</creator><creatorcontrib>DA SILVA, ORLANDO ; GREGSON, DANIEL ; HAMMERBERG, OLE</creatorcontrib><description>OBJECTIVE.To investigate the relationship between Ureaplasma urealyticum and Chlamydia trachomatis colonization of the very low birth weight infant and the development of bronchopulmonary dysplasia (BPD).
METHODS.Endotracheal and/or nasopharyngeal aspirates and clinical data were obtained prospectively from 108 infants with a birth weight of <1501 g and analyzed for U. urealyticum and C. trachomatis by culture and polymerase chain reaction (PCR).
RESULTS.U. urealyticum was detected by culture in 40 (37%) infants and by PCR in 49 (45%) infants on at least one occasion. BPD was present at 28 days in 26 of 40 (65%) U. urealyticum culture-positive infants and 39 of 68 (57%) culturenegative infants (relative risk (RR) 1.13, 95% confidence interval 0.83 to 1.54; P = 0.538). BPD was present at 28 days in 34 of 49 (69%) U. urealyticum PCR-positive infants and in 31 of 59 (53%) PCR-negative infants (RR 1.32, 95% confidence interval 0.97 to 1.79; P = 0.135). At 36 weeks postconceptional age culture-positive or PCR-positive infants were at no greater risk of BPD than infants with negative results (RR = 1.02, P = 0.92 and RR = 1.2, P = 0.523, respectively). In addition the presence of U. urealyticum was not associated with any significant difference in the length of hospital stay, days of ventilation, days of oxygen supplementation, birth weight or gestational age. C. trachomatis was detected in only 2 infants.
CONCLUSION.C. trachomatis was found infrequently in the airways of premature very low birth weight infants. U. urealyticum was frequently detected but its presence was not significant with regard to development of BPD, duration of ventilatory support, oxygen dependency and length of hospital stay.</description><identifier>ISSN: 0891-3668</identifier><identifier>EISSN: 1532-0987</identifier><identifier>DOI: 10.1097/00006454-199704000-00006</identifier><identifier>PMID: 9109137</identifier><identifier>CODEN: PIDJEV</identifier><language>eng</language><publisher>Baltimore, MD: Williams & Wilkins</publisher><subject>Biological and medical sciences ; Birth Weight ; Bronchopulmonary Dysplasia - microbiology ; Bronchopulmonary Dysplasia - therapy ; Chlamydia Infections - diagnosis ; Chlamydia trachomatis - growth & development ; Chlamydia trachomatis - isolation & purification ; Delivery. Postpartum. Lactation ; Disorders ; Female ; Gynecology. Andrology. Obstetrics ; Hospitalization ; Humans ; Infant, Newborn ; Male ; Medical sciences ; Nasopharynx - microbiology ; Oxygen Inhalation Therapy ; Polymerase Chain Reaction ; Respiration, Artificial ; Suction ; Trachea - microbiology ; Ureaplasma Infections - diagnosis ; Ureaplasma urealyticum - growth & development ; Ureaplasma urealyticum - isolation & purification</subject><ispartof>The Pediatric infectious disease journal, 1997-04, Vol.16 (4), p.364-369</ispartof><rights>Williams & Wilkins 1997. All Rights Reserved.</rights><rights>1997 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c5106-8737c3d6f071571d3fe0b2b8fb0b6c9b090aa1542d40cd0696be1546da692bfc3</citedby><cites>FETCH-LOGICAL-c5106-8737c3d6f071571d3fe0b2b8fb0b6c9b090aa1542d40cd0696be1546da692bfc3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27903,27904</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=2636668$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/9109137$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>DA SILVA, ORLANDO</creatorcontrib><creatorcontrib>GREGSON, DANIEL</creatorcontrib><creatorcontrib>HAMMERBERG, OLE</creatorcontrib><title>Role of Ureaplasma urealyticum and Chlamydia trachomatis in development of bronchopulmonary dysplasia in very low birth weight infants</title><title>The Pediatric infectious disease journal</title><addtitle>Pediatr Infect Dis J</addtitle><description>OBJECTIVE.To investigate the relationship between Ureaplasma urealyticum and Chlamydia trachomatis colonization of the very low birth weight infant and the development of bronchopulmonary dysplasia (BPD).
METHODS.Endotracheal and/or nasopharyngeal aspirates and clinical data were obtained prospectively from 108 infants with a birth weight of <1501 g and analyzed for U. urealyticum and C. trachomatis by culture and polymerase chain reaction (PCR).
RESULTS.U. urealyticum was detected by culture in 40 (37%) infants and by PCR in 49 (45%) infants on at least one occasion. BPD was present at 28 days in 26 of 40 (65%) U. urealyticum culture-positive infants and 39 of 68 (57%) culturenegative infants (relative risk (RR) 1.13, 95% confidence interval 0.83 to 1.54; P = 0.538). BPD was present at 28 days in 34 of 49 (69%) U. urealyticum PCR-positive infants and in 31 of 59 (53%) PCR-negative infants (RR 1.32, 95% confidence interval 0.97 to 1.79; P = 0.135). At 36 weeks postconceptional age culture-positive or PCR-positive infants were at no greater risk of BPD than infants with negative results (RR = 1.02, P = 0.92 and RR = 1.2, P = 0.523, respectively). In addition the presence of U. urealyticum was not associated with any significant difference in the length of hospital stay, days of ventilation, days of oxygen supplementation, birth weight or gestational age. C. trachomatis was detected in only 2 infants.
CONCLUSION.C. trachomatis was found infrequently in the airways of premature very low birth weight infants. U. urealyticum was frequently detected but its presence was not significant with regard to development of BPD, duration of ventilatory support, oxygen dependency and length of hospital stay.</description><subject>Biological and medical sciences</subject><subject>Birth Weight</subject><subject>Bronchopulmonary Dysplasia - microbiology</subject><subject>Bronchopulmonary Dysplasia - therapy</subject><subject>Chlamydia Infections - diagnosis</subject><subject>Chlamydia trachomatis - growth & development</subject><subject>Chlamydia trachomatis - isolation & purification</subject><subject>Delivery. Postpartum. Lactation</subject><subject>Disorders</subject><subject>Female</subject><subject>Gynecology. Andrology. Obstetrics</subject><subject>Hospitalization</subject><subject>Humans</subject><subject>Infant, Newborn</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Nasopharynx - microbiology</subject><subject>Oxygen Inhalation Therapy</subject><subject>Polymerase Chain Reaction</subject><subject>Respiration, Artificial</subject><subject>Suction</subject><subject>Trachea - microbiology</subject><subject>Ureaplasma Infections - diagnosis</subject><subject>Ureaplasma urealyticum - growth & development</subject><subject>Ureaplasma urealyticum - isolation & purification</subject><issn>0891-3668</issn><issn>1532-0987</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1997</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkt9uFCEYxYnR1G31EUy4MN5NC8MMDJdmY9WkSRNjrwl_nVEYRmC62Rfoc8u6270zcgN85_cdIAcAIEbXGHF2g-qgXd81mHOGurpr_pZegA3uSdsgPrCXYIMGjhtC6fAaXOb8sxKkw-gCXPDqggnbgKdv0VsYHXxIVi5e5iDhWpd-Xya9BihnA7ejl2FvJglLknqMQZYpw2mGxj5aH5dg53KwUCnOVV5WH-Is0x6afT5Y1sYKP9pa8XEH1ZTKCHd2-jGWKjg5l_wGvHLSZ_v2NF-Bh9tP37dfmrv7z1-3H-8a3WNEm4ERpomhDjHcM2yIs0i1anAKKaq5QhxJifuuNR3SBlFOla1baiTlrXKaXIEPR98lxd-rzUWEKWvrvZxtXLNgA-9Zi4b_gpi2jHNOKzgcQZ1izsk6saQp1NcLjMQhK_GclThndSzV1nenM1YVrDk3nsKp-vuTLrOW3iU56ymfsZbWZOnhqt0R20VfbMq__LqzSYw1xDKKf_0U8gfRU649</recordid><startdate>199704</startdate><enddate>199704</enddate><creator>DA SILVA, ORLANDO</creator><creator>GREGSON, DANIEL</creator><creator>HAMMERBERG, OLE</creator><general>Williams & Wilkins</general><general>Lippincott</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QL</scope><scope>C1K</scope><scope>7X8</scope></search><sort><creationdate>199704</creationdate><title>Role of Ureaplasma urealyticum and Chlamydia trachomatis in development of bronchopulmonary dysplasia in very low birth weight infants</title><author>DA SILVA, ORLANDO ; GREGSON, DANIEL ; HAMMERBERG, OLE</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5106-8737c3d6f071571d3fe0b2b8fb0b6c9b090aa1542d40cd0696be1546da692bfc3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1997</creationdate><topic>Biological and medical sciences</topic><topic>Birth Weight</topic><topic>Bronchopulmonary Dysplasia - microbiology</topic><topic>Bronchopulmonary Dysplasia - therapy</topic><topic>Chlamydia Infections - diagnosis</topic><topic>Chlamydia trachomatis - growth & development</topic><topic>Chlamydia trachomatis - isolation & purification</topic><topic>Delivery. Postpartum. Lactation</topic><topic>Disorders</topic><topic>Female</topic><topic>Gynecology. Andrology. Obstetrics</topic><topic>Hospitalization</topic><topic>Humans</topic><topic>Infant, Newborn</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Nasopharynx - microbiology</topic><topic>Oxygen Inhalation Therapy</topic><topic>Polymerase Chain Reaction</topic><topic>Respiration, Artificial</topic><topic>Suction</topic><topic>Trachea - microbiology</topic><topic>Ureaplasma Infections - diagnosis</topic><topic>Ureaplasma urealyticum - growth & development</topic><topic>Ureaplasma urealyticum - isolation & purification</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>DA SILVA, ORLANDO</creatorcontrib><creatorcontrib>GREGSON, DANIEL</creatorcontrib><creatorcontrib>HAMMERBERG, OLE</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Environmental Sciences and Pollution Management</collection><collection>MEDLINE - Academic</collection><jtitle>The Pediatric infectious disease journal</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>DA SILVA, ORLANDO</au><au>GREGSON, DANIEL</au><au>HAMMERBERG, OLE</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Role of Ureaplasma urealyticum and Chlamydia trachomatis in development of bronchopulmonary dysplasia in very low birth weight infants</atitle><jtitle>The Pediatric infectious disease journal</jtitle><addtitle>Pediatr Infect Dis J</addtitle><date>1997-04</date><risdate>1997</risdate><volume>16</volume><issue>4</issue><spage>364</spage><epage>369</epage><pages>364-369</pages><issn>0891-3668</issn><eissn>1532-0987</eissn><coden>PIDJEV</coden><abstract>OBJECTIVE.To investigate the relationship between Ureaplasma urealyticum and Chlamydia trachomatis colonization of the very low birth weight infant and the development of bronchopulmonary dysplasia (BPD).
METHODS.Endotracheal and/or nasopharyngeal aspirates and clinical data were obtained prospectively from 108 infants with a birth weight of <1501 g and analyzed for U. urealyticum and C. trachomatis by culture and polymerase chain reaction (PCR).
RESULTS.U. urealyticum was detected by culture in 40 (37%) infants and by PCR in 49 (45%) infants on at least one occasion. BPD was present at 28 days in 26 of 40 (65%) U. urealyticum culture-positive infants and 39 of 68 (57%) culturenegative infants (relative risk (RR) 1.13, 95% confidence interval 0.83 to 1.54; P = 0.538). BPD was present at 28 days in 34 of 49 (69%) U. urealyticum PCR-positive infants and in 31 of 59 (53%) PCR-negative infants (RR 1.32, 95% confidence interval 0.97 to 1.79; P = 0.135). At 36 weeks postconceptional age culture-positive or PCR-positive infants were at no greater risk of BPD than infants with negative results (RR = 1.02, P = 0.92 and RR = 1.2, P = 0.523, respectively). In addition the presence of U. urealyticum was not associated with any significant difference in the length of hospital stay, days of ventilation, days of oxygen supplementation, birth weight or gestational age. C. trachomatis was detected in only 2 infants.
CONCLUSION.C. trachomatis was found infrequently in the airways of premature very low birth weight infants. U. urealyticum was frequently detected but its presence was not significant with regard to development of BPD, duration of ventilatory support, oxygen dependency and length of hospital stay.</abstract><cop>Baltimore, MD</cop><cop>Philadelphia, PA</cop><cop>Hagerstown, MD</cop><pub>Williams & Wilkins</pub><pmid>9109137</pmid><doi>10.1097/00006454-199704000-00006</doi><tpages>6</tpages></addata></record> |
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| subjects | Biological and medical sciences Birth Weight Bronchopulmonary Dysplasia - microbiology Bronchopulmonary Dysplasia - therapy Chlamydia Infections - diagnosis Chlamydia trachomatis - growth & development Chlamydia trachomatis - isolation & purification Delivery. Postpartum. Lactation Disorders Female Gynecology. Andrology. Obstetrics Hospitalization Humans Infant, Newborn Male Medical sciences Nasopharynx - microbiology Oxygen Inhalation Therapy Polymerase Chain Reaction Respiration, Artificial Suction Trachea - microbiology Ureaplasma Infections - diagnosis Ureaplasma urealyticum - growth & development Ureaplasma urealyticum - isolation & purification |
| title | Role of Ureaplasma urealyticum and Chlamydia trachomatis in development of bronchopulmonary dysplasia in very low birth weight infants |
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