Evidence for a major gene determining the resistance of Indonesian Thin Tail sheep against Fasciola gigantica
The genetic basis of the high resistance of Indonesian Thin Tail (ITT) sheep against Fasciola gigantica has been studied by measuring the resistance levels of ITT sheep, St. Croix sheep and their F 2 and F 3 crossbreds. All of the sheep were bred and reared in the same environment. Approximately hal...
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| Veröffentlicht in: | Veterinary parasitology 1997-03, Vol.68 (4), p.309-314 |
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| creator | Roberts, J.A. Widjayanti, S. Estuningsih, E. Hetzel, D.J. |
| description | The genetic basis of the high resistance of Indonesian Thin Tail (ITT) sheep against
Fasciola gigantica has been studied by measuring the resistance levels of ITT sheep, St. Croix sheep and their F
2 and F
3 crossbreds. All of the sheep were bred and reared in the same environment. Approximately half of the F
2 and F
3 crossbreds were as resistant as the ITT parental breed, one-quarter had the low resistance of the St. Croix parental breed and the rest had an intermediate level of resistance. It is concluded that the high resistance is determined by a major gene with incomplete dominance. The prevalence of the gene in the ITT sheep population is estimated to be about 90%. The resistance may be innate or acquired; but, regardless of the mechanism, it could be used to control fasciolosis caused by
F. gigantica by breed substitution or by crossbreeding with other breeds of sheep. |
| doi_str_mv | 10.1016/S0304-4017(96)01068-0 |
| format | Article |
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Fasciola gigantica has been studied by measuring the resistance levels of ITT sheep, St. Croix sheep and their F
2 and F
3 crossbreds. All of the sheep were bred and reared in the same environment. Approximately half of the F
2 and F
3 crossbreds were as resistant as the ITT parental breed, one-quarter had the low resistance of the St. Croix parental breed and the rest had an intermediate level of resistance. It is concluded that the high resistance is determined by a major gene with incomplete dominance. The prevalence of the gene in the ITT sheep population is estimated to be about 90%. The resistance may be innate or acquired; but, regardless of the mechanism, it could be used to control fasciolosis caused by
F. gigantica by breed substitution or by crossbreeding with other breeds of sheep.</description><identifier>ISSN: 0304-4017</identifier><identifier>EISSN: 1873-2550</identifier><identifier>DOI: 10.1016/S0304-4017(96)01068-0</identifier><identifier>PMID: 9106952</identifier><language>eng</language><publisher>Netherlands: Elsevier B.V</publisher><subject>Animals ; Antibodies, Helminth - blood ; Crossbreeding ; Crosses, Genetic ; Enzyme-Linked Immunosorbent Assay ; Fasciola - immunology ; Fasciola - isolation & purification ; FASCIOLA GIGANTICA ; Fascioliasis - immunology ; Fascioliasis - pathology ; Fascioliasis - veterinary ; Female ; GENE ; GENES ; GENETICA ; GENETICS ; GENETIQUE ; Immunity, Innate - genetics ; Indonesia ; Liver - parasitology ; Liver - pathology ; OVIN ; OVINOS ; PEST RESISTANCE ; Resistance ; RESISTANCE AUX ORGANISMES NUISIBLES ; RESISTENCIA A LAS PLAGAS ; SHEEP ; Sheep - genetics ; Sheep - immunology ; Sheep Diseases ; Sheep-Trematoda</subject><ispartof>Veterinary parasitology, 1997-03, Vol.68 (4), p.309-314</ispartof><rights>1997</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c382t-738eea63821a52742ee2f814f17ab407e754b540b0a3822464b6ebbe644561343</citedby><cites>FETCH-LOGICAL-c382t-738eea63821a52742ee2f814f17ab407e754b540b0a3822464b6ebbe644561343</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/S0304-4017(96)01068-0$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,777,781,3537,27905,27906,45976</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/9106952$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Roberts, J.A.</creatorcontrib><creatorcontrib>Widjayanti, S.</creatorcontrib><creatorcontrib>Estuningsih, E.</creatorcontrib><creatorcontrib>Hetzel, D.J.</creatorcontrib><title>Evidence for a major gene determining the resistance of Indonesian Thin Tail sheep against Fasciola gigantica</title><title>Veterinary parasitology</title><addtitle>Vet Parasitol</addtitle><description>The genetic basis of the high resistance of Indonesian Thin Tail (ITT) sheep against
Fasciola gigantica has been studied by measuring the resistance levels of ITT sheep, St. Croix sheep and their F
2 and F
3 crossbreds. All of the sheep were bred and reared in the same environment. Approximately half of the F
2 and F
3 crossbreds were as resistant as the ITT parental breed, one-quarter had the low resistance of the St. Croix parental breed and the rest had an intermediate level of resistance. It is concluded that the high resistance is determined by a major gene with incomplete dominance. The prevalence of the gene in the ITT sheep population is estimated to be about 90%. The resistance may be innate or acquired; but, regardless of the mechanism, it could be used to control fasciolosis caused by
F. gigantica by breed substitution or by crossbreeding with other breeds of sheep.</description><subject>Animals</subject><subject>Antibodies, Helminth - blood</subject><subject>Crossbreeding</subject><subject>Crosses, Genetic</subject><subject>Enzyme-Linked Immunosorbent Assay</subject><subject>Fasciola - immunology</subject><subject>Fasciola - isolation & purification</subject><subject>FASCIOLA GIGANTICA</subject><subject>Fascioliasis - immunology</subject><subject>Fascioliasis - pathology</subject><subject>Fascioliasis - veterinary</subject><subject>Female</subject><subject>GENE</subject><subject>GENES</subject><subject>GENETICA</subject><subject>GENETICS</subject><subject>GENETIQUE</subject><subject>Immunity, Innate - genetics</subject><subject>Indonesia</subject><subject>Liver - parasitology</subject><subject>Liver - pathology</subject><subject>OVIN</subject><subject>OVINOS</subject><subject>PEST RESISTANCE</subject><subject>Resistance</subject><subject>RESISTANCE AUX ORGANISMES NUISIBLES</subject><subject>RESISTENCIA A LAS PLAGAS</subject><subject>SHEEP</subject><subject>Sheep - genetics</subject><subject>Sheep - immunology</subject><subject>Sheep Diseases</subject><subject>Sheep-Trematoda</subject><issn>0304-4017</issn><issn>1873-2550</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1997</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkU1v1DAQhi0EKkvhJ1TyCcEhME78kZwQqlqotIID5WxNkknWVWIvdrZS_32d7qoce_FYfp-xrWcYuxDwRYDQX_9ABbKQIMynRn8GAbou4BXbiNpURakUvGabZ-Qte5fSHQBI0OaMnTUZb1S5YfPVvevJd8SHEDnyGe9yHckT72mhODvv_MiXHfFIyaUFVzYM_Mb3wecT9Px25_KCbuJpR7TnOKLzaeHXmDoXJuSjG9EvrsP37M2AU6IPp3rO_l5f3V7-LLa_f9xcft8WXVWXS2Gqmgh13gtUpZElUTnUQg7CYCvBkFGyVRJawMyUUstWU9uSllJpUcnqnH083ruP4d-B0mJnlzqaJvQUDsmaulFKa8igOoJdDClFGuw-uhnjgxVgV832SbNdHdpG2yfNdu27OD1waGfqn7tOXv_nAwaLY3TJ_tqKpqnzCKpK5fzbMads4d5RtFnVOobeReoW2wf3wg8eAQ4DlMk</recordid><startdate>19970301</startdate><enddate>19970301</enddate><creator>Roberts, J.A.</creator><creator>Widjayanti, S.</creator><creator>Estuningsih, E.</creator><creator>Hetzel, D.J.</creator><general>Elsevier B.V</general><scope>FBQ</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19970301</creationdate><title>Evidence for a major gene determining the resistance of Indonesian Thin Tail sheep against Fasciola gigantica</title><author>Roberts, J.A. ; Widjayanti, S. ; Estuningsih, E. ; Hetzel, D.J.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c382t-738eea63821a52742ee2f814f17ab407e754b540b0a3822464b6ebbe644561343</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1997</creationdate><topic>Animals</topic><topic>Antibodies, Helminth - blood</topic><topic>Crossbreeding</topic><topic>Crosses, Genetic</topic><topic>Enzyme-Linked Immunosorbent Assay</topic><topic>Fasciola - immunology</topic><topic>Fasciola - isolation & purification</topic><topic>FASCIOLA GIGANTICA</topic><topic>Fascioliasis - immunology</topic><topic>Fascioliasis - pathology</topic><topic>Fascioliasis - veterinary</topic><topic>Female</topic><topic>GENE</topic><topic>GENES</topic><topic>GENETICA</topic><topic>GENETICS</topic><topic>GENETIQUE</topic><topic>Immunity, Innate - genetics</topic><topic>Indonesia</topic><topic>Liver - parasitology</topic><topic>Liver - pathology</topic><topic>OVIN</topic><topic>OVINOS</topic><topic>PEST RESISTANCE</topic><topic>Resistance</topic><topic>RESISTANCE AUX ORGANISMES NUISIBLES</topic><topic>RESISTENCIA A LAS PLAGAS</topic><topic>SHEEP</topic><topic>Sheep - genetics</topic><topic>Sheep - immunology</topic><topic>Sheep Diseases</topic><topic>Sheep-Trematoda</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Roberts, J.A.</creatorcontrib><creatorcontrib>Widjayanti, S.</creatorcontrib><creatorcontrib>Estuningsih, E.</creatorcontrib><creatorcontrib>Hetzel, D.J.</creatorcontrib><collection>AGRIS</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Veterinary parasitology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Roberts, J.A.</au><au>Widjayanti, S.</au><au>Estuningsih, E.</au><au>Hetzel, D.J.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Evidence for a major gene determining the resistance of Indonesian Thin Tail sheep against Fasciola gigantica</atitle><jtitle>Veterinary parasitology</jtitle><addtitle>Vet Parasitol</addtitle><date>1997-03-01</date><risdate>1997</risdate><volume>68</volume><issue>4</issue><spage>309</spage><epage>314</epage><pages>309-314</pages><issn>0304-4017</issn><eissn>1873-2550</eissn><abstract>The genetic basis of the high resistance of Indonesian Thin Tail (ITT) sheep against
Fasciola gigantica has been studied by measuring the resistance levels of ITT sheep, St. Croix sheep and their F
2 and F
3 crossbreds. All of the sheep were bred and reared in the same environment. Approximately half of the F
2 and F
3 crossbreds were as resistant as the ITT parental breed, one-quarter had the low resistance of the St. Croix parental breed and the rest had an intermediate level of resistance. It is concluded that the high resistance is determined by a major gene with incomplete dominance. The prevalence of the gene in the ITT sheep population is estimated to be about 90%. The resistance may be innate or acquired; but, regardless of the mechanism, it could be used to control fasciolosis caused by
F. gigantica by breed substitution or by crossbreeding with other breeds of sheep.</abstract><cop>Netherlands</cop><pub>Elsevier B.V</pub><pmid>9106952</pmid><doi>10.1016/S0304-4017(96)01068-0</doi><tpages>6</tpages></addata></record> |
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| ispartof | Veterinary parasitology, 1997-03, Vol.68 (4), p.309-314 |
| issn | 0304-4017 1873-2550 |
| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Animals Antibodies, Helminth - blood Crossbreeding Crosses, Genetic Enzyme-Linked Immunosorbent Assay Fasciola - immunology Fasciola - isolation & purification FASCIOLA GIGANTICA Fascioliasis - immunology Fascioliasis - pathology Fascioliasis - veterinary Female GENE GENES GENETICA GENETICS GENETIQUE Immunity, Innate - genetics Indonesia Liver - parasitology Liver - pathology OVIN OVINOS PEST RESISTANCE Resistance RESISTANCE AUX ORGANISMES NUISIBLES RESISTENCIA A LAS PLAGAS SHEEP Sheep - genetics Sheep - immunology Sheep Diseases Sheep-Trematoda |
| title | Evidence for a major gene determining the resistance of Indonesian Thin Tail sheep against Fasciola gigantica |
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