Aging reduces venous distensibility and the venodilatory response to nitroglycerin in normal subjects
To determine if aging alters venous tone, venous distensibility was measured during control conditions and after the administration of nitroglycerin (0.8-mg spray) to 50 subjects ranging in age from 21 to 78 years. The mean arterial pressure decreased and the heart rate increased significantly after...
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| Veröffentlicht in: | The American journal of cardiology 1989-05, Vol.63 (17), p.1267-1270 |
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| container_title | The American journal of cardiology |
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| creator | Gascho, Joseph A. Fanelli, Claude Zelis, Robert |
| description | To determine if aging alters venous tone, venous distensibility was measured during control conditions and after the administration of nitroglycerin (0.8-mg spray) to 50 subjects ranging in age from 21 to 78 years. The mean arterial pressure decreased and the heart rate increased significantly after nitroglycerin. Control venous distensibility, measured after the inflation of an upper arm cuff to 30 mm Hg above cuff zero (VV[30]) was 2.69 ± 1.26 (standard deviation) cc/100 cc arm. The VV[30] increased to 3.06 ± 1.43 cc/100 cc arm after the administration of nitroglycerin. There was a significant relation between age and baseline venous distensibility (r = 0.53, p < 0.001) and between age and the change in venous distensibility after nitroglycerin (r = 0.56, p < 0.001). Both baseline venous distensibility and the venodilatory response to nitroglycerin decreased with age. There was no significant relation between systemic arterial pressure and baseline venous distensibility or between arterial pressure and the venodilatory response to nitroglycerin. Aging appears to diminish baseline venous distensibility and attenuate the venodilatory response to nitroglycerin. |
| doi_str_mv | 10.1016/0002-9149(89)90188-4 |
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The mean arterial pressure decreased and the heart rate increased significantly after nitroglycerin. Control venous distensibility, measured after the inflation of an upper arm cuff to 30 mm Hg above cuff zero (VV[30]) was 2.69 ± 1.26 (standard deviation) cc/100 cc arm. The VV[30] increased to 3.06 ± 1.43 cc/100 cc arm after the administration of nitroglycerin. There was a significant relation between age and baseline venous distensibility (r = 0.53, p < 0.001) and between age and the change in venous distensibility after nitroglycerin (r = 0.56, p < 0.001). Both baseline venous distensibility and the venodilatory response to nitroglycerin decreased with age. There was no significant relation between systemic arterial pressure and baseline venous distensibility or between arterial pressure and the venodilatory response to nitroglycerin. Aging appears to diminish baseline venous distensibility and attenuate the venodilatory response to nitroglycerin.</description><identifier>ISSN: 0002-9149</identifier><identifier>EISSN: 1879-1913</identifier><identifier>DOI: 10.1016/0002-9149(89)90188-4</identifier><identifier>PMID: 2496597</identifier><identifier>CODEN: AJCDAG</identifier><language>eng</language><publisher>New York, NY: Elsevier Inc</publisher><subject>Adult ; Aged ; Aged, 80 and over ; Aging - physiology ; Antianginal agents. Coronary vasodilator agents ; Biological and medical sciences ; Cardiovascular system ; Elasticity ; Female ; Forearm - blood supply ; Hemodynamics - drug effects ; Humans ; Male ; Medical sciences ; Middle Aged ; Muscle, Smooth, Vascular - drug effects ; Nitroglycerin - pharmacology ; Pharmacology. Drug treatments ; Reference Values ; Vasodilation - drug effects ; Veins - drug effects ; Veins - physiology</subject><ispartof>The American journal of cardiology, 1989-05, Vol.63 (17), p.1267-1270</ispartof><rights>1989</rights><rights>1990 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c386t-3c98202b9e1b4a5a99d221f4f8a93ac330c5bed212e201fa218934ab38fdffb23</citedby><cites>FETCH-LOGICAL-c386t-3c98202b9e1b4a5a99d221f4f8a93ac330c5bed212e201fa218934ab38fdffb23</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/0002-9149(89)90188-4$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,778,782,3539,27907,27908,45978</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=6967304$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/2496597$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Gascho, Joseph A.</creatorcontrib><creatorcontrib>Fanelli, Claude</creatorcontrib><creatorcontrib>Zelis, Robert</creatorcontrib><title>Aging reduces venous distensibility and the venodilatory response to nitroglycerin in normal subjects</title><title>The American journal of cardiology</title><addtitle>Am J Cardiol</addtitle><description>To determine if aging alters venous tone, venous distensibility was measured during control conditions and after the administration of nitroglycerin (0.8-mg spray) to 50 subjects ranging in age from 21 to 78 years. The mean arterial pressure decreased and the heart rate increased significantly after nitroglycerin. Control venous distensibility, measured after the inflation of an upper arm cuff to 30 mm Hg above cuff zero (VV[30]) was 2.69 ± 1.26 (standard deviation) cc/100 cc arm. The VV[30] increased to 3.06 ± 1.43 cc/100 cc arm after the administration of nitroglycerin. There was a significant relation between age and baseline venous distensibility (r = 0.53, p < 0.001) and between age and the change in venous distensibility after nitroglycerin (r = 0.56, p < 0.001). Both baseline venous distensibility and the venodilatory response to nitroglycerin decreased with age. There was no significant relation between systemic arterial pressure and baseline venous distensibility or between arterial pressure and the venodilatory response to nitroglycerin. Aging appears to diminish baseline venous distensibility and attenuate the venodilatory response to nitroglycerin.</description><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Aging - physiology</subject><subject>Antianginal agents. Coronary vasodilator agents</subject><subject>Biological and medical sciences</subject><subject>Cardiovascular system</subject><subject>Elasticity</subject><subject>Female</subject><subject>Forearm - blood supply</subject><subject>Hemodynamics - drug effects</subject><subject>Humans</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Muscle, Smooth, Vascular - drug effects</subject><subject>Nitroglycerin - pharmacology</subject><subject>Pharmacology. Drug treatments</subject><subject>Reference Values</subject><subject>Vasodilation - drug effects</subject><subject>Veins - drug effects</subject><subject>Veins - physiology</subject><issn>0002-9149</issn><issn>1879-1913</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1989</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kF1rFDEUhoNY6lr9Bwq5kKIXo_ma2eRGKKVqoeCNXodMcrKmzCZrzkxh_73Z7rKXwoFweD84eQh5x9lnzvjwhTEmOsOV-ajNJ8O41p16QVZcr03HDZcvyepseUVeIz62lfN-uCSXQpmhN-sVgZtNyhtaISwekD5BLgvSkHCGjGlMU5r31OVA5z_wrIY0ubnUfYvgrmQEOhea01zLZtp7qCnTNrnUrZsoLuMj-BnfkIvoJoS3p_eK_P529-v2R_fw8_v97c1D56Ue5k56owUTowE-Ktc7Y4IQPKqonZHOS8l8P0IQXIBgPDrBtZHKjVLHEOMo5BW5Pvbuavm7AM52m9DDNLkM7V92rU3fCyWbUR2NvhbECtHuatq6urec2QNde0BnD-isNvaZrlUt9v7Uv4xbCOfQCWfTP5x0h95NsbrsE55tgxnWkh1qvh5t0Fg8JagWfYLsIaTacNlQ0v_v-Ae8vphD</recordid><startdate>19890515</startdate><enddate>19890515</enddate><creator>Gascho, Joseph A.</creator><creator>Fanelli, Claude</creator><creator>Zelis, Robert</creator><general>Elsevier Inc</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19890515</creationdate><title>Aging reduces venous distensibility and the venodilatory response to nitroglycerin in normal subjects</title><author>Gascho, Joseph A. ; Fanelli, Claude ; Zelis, Robert</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c386t-3c98202b9e1b4a5a99d221f4f8a93ac330c5bed212e201fa218934ab38fdffb23</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1989</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Aging - physiology</topic><topic>Antianginal agents. Coronary vasodilator agents</topic><topic>Biological and medical sciences</topic><topic>Cardiovascular system</topic><topic>Elasticity</topic><topic>Female</topic><topic>Forearm - blood supply</topic><topic>Hemodynamics - drug effects</topic><topic>Humans</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Muscle, Smooth, Vascular - drug effects</topic><topic>Nitroglycerin - pharmacology</topic><topic>Pharmacology. Drug treatments</topic><topic>Reference Values</topic><topic>Vasodilation - drug effects</topic><topic>Veins - drug effects</topic><topic>Veins - physiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Gascho, Joseph A.</creatorcontrib><creatorcontrib>Fanelli, Claude</creatorcontrib><creatorcontrib>Zelis, Robert</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>The American journal of cardiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Gascho, Joseph A.</au><au>Fanelli, Claude</au><au>Zelis, Robert</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Aging reduces venous distensibility and the venodilatory response to nitroglycerin in normal subjects</atitle><jtitle>The American journal of cardiology</jtitle><addtitle>Am J Cardiol</addtitle><date>1989-05-15</date><risdate>1989</risdate><volume>63</volume><issue>17</issue><spage>1267</spage><epage>1270</epage><pages>1267-1270</pages><issn>0002-9149</issn><eissn>1879-1913</eissn><coden>AJCDAG</coden><abstract>To determine if aging alters venous tone, venous distensibility was measured during control conditions and after the administration of nitroglycerin (0.8-mg spray) to 50 subjects ranging in age from 21 to 78 years. The mean arterial pressure decreased and the heart rate increased significantly after nitroglycerin. Control venous distensibility, measured after the inflation of an upper arm cuff to 30 mm Hg above cuff zero (VV[30]) was 2.69 ± 1.26 (standard deviation) cc/100 cc arm. The VV[30] increased to 3.06 ± 1.43 cc/100 cc arm after the administration of nitroglycerin. There was a significant relation between age and baseline venous distensibility (r = 0.53, p < 0.001) and between age and the change in venous distensibility after nitroglycerin (r = 0.56, p < 0.001). Both baseline venous distensibility and the venodilatory response to nitroglycerin decreased with age. There was no significant relation between systemic arterial pressure and baseline venous distensibility or between arterial pressure and the venodilatory response to nitroglycerin. Aging appears to diminish baseline venous distensibility and attenuate the venodilatory response to nitroglycerin.</abstract><cop>New York, NY</cop><pub>Elsevier Inc</pub><pmid>2496597</pmid><doi>10.1016/0002-9149(89)90188-4</doi><tpages>4</tpages></addata></record> |
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| subjects | Adult Aged Aged, 80 and over Aging - physiology Antianginal agents. Coronary vasodilator agents Biological and medical sciences Cardiovascular system Elasticity Female Forearm - blood supply Hemodynamics - drug effects Humans Male Medical sciences Middle Aged Muscle, Smooth, Vascular - drug effects Nitroglycerin - pharmacology Pharmacology. Drug treatments Reference Values Vasodilation - drug effects Veins - drug effects Veins - physiology |
| title | Aging reduces venous distensibility and the venodilatory response to nitroglycerin in normal subjects |
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