Selective vagal postganglionic innervation of the sinoatrial and atrioventricular nodes in the non-human primate
The distribution of parasympathetic postganglionic nerves to the atrioventricular (AVN) and sinoatrial nodal (SAN) regions was investigated in the non-human primate heart. Eight male monkeys ( Macaca fascicularis) weighing 5.5–7.0 kg. were anesthetized (α-chloralose, 50 mg/kg and urethane, 500 mg/kg...
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| Veröffentlicht in: | Journal of the autonomic nervous system 1989-02, Vol.26 (1), p.27-36 |
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| creator | Billman, George E. Hoskins, Richard S. Randall, David C. Randall, Walter C. Hamlin, Robert L. Lin, Young C. |
| description | The distribution of parasympathetic postganglionic nerves to the atrioventricular (AVN) and sinoatrial nodal (SAN) regions was investigated in the non-human primate heart. Eight male monkeys (
Macaca fascicularis) weighing 5.5–7.0 kg. were anesthetized (α-chloralose, 50 mg/kg and urethane, 500 mg/kg) and instrumented to measure arterial pressure, electrocardiogram, atrial and ventricular electrograms. The cervical vagi were electrically stimulated (20 Hz, 4 V, 2 ms) before and after selective denervation (D) of the AVN and/or SAN. Vagal stimulation was repeated during atrial pacing to assess parasympathetic modulation of AVN conduction. Ablation of parasympathetic pathways to the AVN, accomplished by the disruption of the epicardial fat and surface muscle layer at the junction of the inferior vena cava and inferior left atrium eliminated (
P < 0.01) the dromotropic effects of vagal stimulation without affecting the heart rate response (right vagus, before D, paced: atrial rate 218.0 ± 6.3, ventricular rate 67.1 ± 23.7; after D: atrial rate 210.3 ± 6.4, ventricular rate 210.3 ± 6.4 beats/min,
x
̄
±
S.D.
). In sharp contrast, surgical dissection of the fat pad overlying the right pulmonary vein-superior vena cava junction significantly (
P > 0.01) attenuated negative chronotropic effects of vagal stimulation (left vagus, before D the R-R interval increased by 832.7 ± 146.4 ms, 209.5% increase; after D 37.4 ± 18.0 ms, 8.8% increase). These data demonstrate discrete vagal efferent pathways innervate both the SAN and AVN regions of the non-human primate heart. |
| doi_str_mv | 10.1016/0165-1838(89)90104-5 |
| format | Article |
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Macaca fascicularis) weighing 5.5–7.0 kg. were anesthetized (α-chloralose, 50 mg/kg and urethane, 500 mg/kg) and instrumented to measure arterial pressure, electrocardiogram, atrial and ventricular electrograms. The cervical vagi were electrically stimulated (20 Hz, 4 V, 2 ms) before and after selective denervation (D) of the AVN and/or SAN. Vagal stimulation was repeated during atrial pacing to assess parasympathetic modulation of AVN conduction. Ablation of parasympathetic pathways to the AVN, accomplished by the disruption of the epicardial fat and surface muscle layer at the junction of the inferior vena cava and inferior left atrium eliminated (
P < 0.01) the dromotropic effects of vagal stimulation without affecting the heart rate response (right vagus, before D, paced: atrial rate 218.0 ± 6.3, ventricular rate 67.1 ± 23.7; after D: atrial rate 210.3 ± 6.4, ventricular rate 210.3 ± 6.4 beats/min,
x
̄
±
S.D.
). In sharp contrast, surgical dissection of the fat pad overlying the right pulmonary vein-superior vena cava junction significantly (
P > 0.01) attenuated negative chronotropic effects of vagal stimulation (left vagus, before D the R-R interval increased by 832.7 ± 146.4 ms, 209.5% increase; after D 37.4 ± 18.0 ms, 8.8% increase). These data demonstrate discrete vagal efferent pathways innervate both the SAN and AVN regions of the non-human primate heart.</description><identifier>ISSN: 0165-1838</identifier><identifier>EISSN: 1872-7476</identifier><identifier>DOI: 10.1016/0165-1838(89)90104-5</identifier><identifier>PMID: 2708782</identifier><identifier>CODEN: JASYDS</identifier><language>eng</language><publisher>Amsterdam: Elsevier B.V</publisher><subject>Animals ; Atrioventricular block ; Atrioventricular node ; Atrioventricular Node - innervation ; Atrioventricular Node - physiology ; Biological and medical sciences ; Cardiac parasympathetic innervation ; Chronotropic control ; Dromotropic control ; Electric Stimulation ; Fundamental and applied biological sciences. Psychology ; Ganglia, Parasympathetic - physiology ; Heart ; Heart Conduction System - innervation ; Heart Rate ; Macaca - anatomy & histology ; Macaca fascicularis ; Macaca fascicularis - anatomy & histology ; Male ; Selective parasympathectomy ; Sinoatrial node ; Sinoatrial Node - innervation ; Sinoatrial Node - physiology ; Vagus Nerve - anatomy & histology ; Vagus Nerve - physiology ; Vertebrates: cardiovascular system</subject><ispartof>Journal of the autonomic nervous system, 1989-02, Vol.26 (1), p.27-36</ispartof><rights>1989</rights><rights>1990 INIST-CNRS</rights><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c417t-9f4cd3a269a840252707325921bd694777cc0b1da7e3f4135282e8e835b6ad3e3</citedby><cites>FETCH-LOGICAL-c417t-9f4cd3a269a840252707325921bd694777cc0b1da7e3f4135282e8e835b6ad3e3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27923,27924</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=6965197$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/2708782$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Billman, George E.</creatorcontrib><creatorcontrib>Hoskins, Richard S.</creatorcontrib><creatorcontrib>Randall, David C.</creatorcontrib><creatorcontrib>Randall, Walter C.</creatorcontrib><creatorcontrib>Hamlin, Robert L.</creatorcontrib><creatorcontrib>Lin, Young C.</creatorcontrib><title>Selective vagal postganglionic innervation of the sinoatrial and atrioventricular nodes in the non-human primate</title><title>Journal of the autonomic nervous system</title><addtitle>J Auton Nerv Syst</addtitle><description>The distribution of parasympathetic postganglionic nerves to the atrioventricular (AVN) and sinoatrial nodal (SAN) regions was investigated in the non-human primate heart. Eight male monkeys (
Macaca fascicularis) weighing 5.5–7.0 kg. were anesthetized (α-chloralose, 50 mg/kg and urethane, 500 mg/kg) and instrumented to measure arterial pressure, electrocardiogram, atrial and ventricular electrograms. The cervical vagi were electrically stimulated (20 Hz, 4 V, 2 ms) before and after selective denervation (D) of the AVN and/or SAN. Vagal stimulation was repeated during atrial pacing to assess parasympathetic modulation of AVN conduction. Ablation of parasympathetic pathways to the AVN, accomplished by the disruption of the epicardial fat and surface muscle layer at the junction of the inferior vena cava and inferior left atrium eliminated (
P < 0.01) the dromotropic effects of vagal stimulation without affecting the heart rate response (right vagus, before D, paced: atrial rate 218.0 ± 6.3, ventricular rate 67.1 ± 23.7; after D: atrial rate 210.3 ± 6.4, ventricular rate 210.3 ± 6.4 beats/min,
x
̄
±
S.D.
). In sharp contrast, surgical dissection of the fat pad overlying the right pulmonary vein-superior vena cava junction significantly (
P > 0.01) attenuated negative chronotropic effects of vagal stimulation (left vagus, before D the R-R interval increased by 832.7 ± 146.4 ms, 209.5% increase; after D 37.4 ± 18.0 ms, 8.8% increase). These data demonstrate discrete vagal efferent pathways innervate both the SAN and AVN regions of the non-human primate heart.</description><subject>Animals</subject><subject>Atrioventricular block</subject><subject>Atrioventricular node</subject><subject>Atrioventricular Node - innervation</subject><subject>Atrioventricular Node - physiology</subject><subject>Biological and medical sciences</subject><subject>Cardiac parasympathetic innervation</subject><subject>Chronotropic control</subject><subject>Dromotropic control</subject><subject>Electric Stimulation</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Ganglia, Parasympathetic - physiology</subject><subject>Heart</subject><subject>Heart Conduction System - innervation</subject><subject>Heart Rate</subject><subject>Macaca - anatomy & histology</subject><subject>Macaca fascicularis</subject><subject>Macaca fascicularis - anatomy & histology</subject><subject>Male</subject><subject>Selective parasympathectomy</subject><subject>Sinoatrial node</subject><subject>Sinoatrial Node - innervation</subject><subject>Sinoatrial Node - physiology</subject><subject>Vagus Nerve - anatomy & histology</subject><subject>Vagus Nerve - physiology</subject><subject>Vertebrates: cardiovascular system</subject><issn>0165-1838</issn><issn>1872-7476</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1989</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkcuKFDEUhoMoY8_oGyhkIaKLGnOp3DaCDI4jDLgYXYd0cqonUp20SVWBb2_6Qi-dRTgJ5zuX_D9Cbyi5poTKT-2IjmquP2jz0RBK-k48QyuqFetUr-RztDojL9Flrb8JoYoYfYEumCJaabZCuwcYwU9xAby4jRvxLtdp49JmjDlFj2NKUBY3tRfOA54eAdeYsptKbLBLAe-veYHUgp9HV3DKAWorPMApp-5x3rqEdyVu3QSv0IvBjRVen-IV-nX79efNXXf_49v3my_3ne-pmjoz9D5wx6RxuidMtIUVZ8Iwug7S9Eop78maBqeADz3lgmkGGjQXa-kCB36F3h_77kr-M0Od7DZWD-PoEuS5WqWNEJSzJ0HaZksmeQP7I-hLrrXAYA9fKn8tJXbviN3LbfdyW23swRErWtnbU_95vYVwLjpZ0PLvTnlXvRuH4pKP9YxJIwU1qmGfjxg00ZYIxVYfIXkIsTQDbcjx_3v8A8IQqGA</recordid><startdate>19890201</startdate><enddate>19890201</enddate><creator>Billman, George E.</creator><creator>Hoskins, Richard S.</creator><creator>Randall, David C.</creator><creator>Randall, Walter C.</creator><creator>Hamlin, Robert L.</creator><creator>Lin, Young C.</creator><general>Elsevier B.V</general><general>Elsevier Science</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>7X8</scope></search><sort><creationdate>19890201</creationdate><title>Selective vagal postganglionic innervation of the sinoatrial and atrioventricular nodes in the non-human primate</title><author>Billman, George E. ; Hoskins, Richard S. ; Randall, David C. ; Randall, Walter C. ; Hamlin, Robert L. ; Lin, Young C.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c417t-9f4cd3a269a840252707325921bd694777cc0b1da7e3f4135282e8e835b6ad3e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1989</creationdate><topic>Animals</topic><topic>Atrioventricular block</topic><topic>Atrioventricular node</topic><topic>Atrioventricular Node - innervation</topic><topic>Atrioventricular Node - physiology</topic><topic>Biological and medical sciences</topic><topic>Cardiac parasympathetic innervation</topic><topic>Chronotropic control</topic><topic>Dromotropic control</topic><topic>Electric Stimulation</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Ganglia, Parasympathetic - physiology</topic><topic>Heart</topic><topic>Heart Conduction System - innervation</topic><topic>Heart Rate</topic><topic>Macaca - anatomy & histology</topic><topic>Macaca fascicularis</topic><topic>Macaca fascicularis - anatomy & histology</topic><topic>Male</topic><topic>Selective parasympathectomy</topic><topic>Sinoatrial node</topic><topic>Sinoatrial Node - innervation</topic><topic>Sinoatrial Node - physiology</topic><topic>Vagus Nerve - anatomy & histology</topic><topic>Vagus Nerve - physiology</topic><topic>Vertebrates: cardiovascular system</topic><toplevel>online_resources</toplevel><creatorcontrib>Billman, George E.</creatorcontrib><creatorcontrib>Hoskins, Richard S.</creatorcontrib><creatorcontrib>Randall, David C.</creatorcontrib><creatorcontrib>Randall, Walter C.</creatorcontrib><creatorcontrib>Hamlin, Robert L.</creatorcontrib><creatorcontrib>Lin, Young C.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of the autonomic nervous system</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Billman, George E.</au><au>Hoskins, Richard S.</au><au>Randall, David C.</au><au>Randall, Walter C.</au><au>Hamlin, Robert L.</au><au>Lin, Young C.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Selective vagal postganglionic innervation of the sinoatrial and atrioventricular nodes in the non-human primate</atitle><jtitle>Journal of the autonomic nervous system</jtitle><addtitle>J Auton Nerv Syst</addtitle><date>1989-02-01</date><risdate>1989</risdate><volume>26</volume><issue>1</issue><spage>27</spage><epage>36</epage><pages>27-36</pages><issn>0165-1838</issn><eissn>1872-7476</eissn><coden>JASYDS</coden><abstract>The distribution of parasympathetic postganglionic nerves to the atrioventricular (AVN) and sinoatrial nodal (SAN) regions was investigated in the non-human primate heart. Eight male monkeys (
Macaca fascicularis) weighing 5.5–7.0 kg. were anesthetized (α-chloralose, 50 mg/kg and urethane, 500 mg/kg) and instrumented to measure arterial pressure, electrocardiogram, atrial and ventricular electrograms. The cervical vagi were electrically stimulated (20 Hz, 4 V, 2 ms) before and after selective denervation (D) of the AVN and/or SAN. Vagal stimulation was repeated during atrial pacing to assess parasympathetic modulation of AVN conduction. Ablation of parasympathetic pathways to the AVN, accomplished by the disruption of the epicardial fat and surface muscle layer at the junction of the inferior vena cava and inferior left atrium eliminated (
P < 0.01) the dromotropic effects of vagal stimulation without affecting the heart rate response (right vagus, before D, paced: atrial rate 218.0 ± 6.3, ventricular rate 67.1 ± 23.7; after D: atrial rate 210.3 ± 6.4, ventricular rate 210.3 ± 6.4 beats/min,
x
̄
±
S.D.
). In sharp contrast, surgical dissection of the fat pad overlying the right pulmonary vein-superior vena cava junction significantly (
P > 0.01) attenuated negative chronotropic effects of vagal stimulation (left vagus, before D the R-R interval increased by 832.7 ± 146.4 ms, 209.5% increase; after D 37.4 ± 18.0 ms, 8.8% increase). These data demonstrate discrete vagal efferent pathways innervate both the SAN and AVN regions of the non-human primate heart.</abstract><cop>Amsterdam</cop><pub>Elsevier B.V</pub><pmid>2708782</pmid><doi>10.1016/0165-1838(89)90104-5</doi><tpages>10</tpages></addata></record> |
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| ispartof | Journal of the autonomic nervous system, 1989-02, Vol.26 (1), p.27-36 |
| issn | 0165-1838 1872-7476 |
| language | eng |
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| subjects | Animals Atrioventricular block Atrioventricular node Atrioventricular Node - innervation Atrioventricular Node - physiology Biological and medical sciences Cardiac parasympathetic innervation Chronotropic control Dromotropic control Electric Stimulation Fundamental and applied biological sciences. Psychology Ganglia, Parasympathetic - physiology Heart Heart Conduction System - innervation Heart Rate Macaca - anatomy & histology Macaca fascicularis Macaca fascicularis - anatomy & histology Male Selective parasympathectomy Sinoatrial node Sinoatrial Node - innervation Sinoatrial Node - physiology Vagus Nerve - anatomy & histology Vagus Nerve - physiology Vertebrates: cardiovascular system |
| title | Selective vagal postganglionic innervation of the sinoatrial and atrioventricular nodes in the non-human primate |
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